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Rapgef2 Rap guanine nucleotide exchange factor (GEF) 2 [ Mus musculus (house mouse) ]

Gene ID: 76089, updated on 11-Apr-2024

Summary

Official Symbol
Rapgef2provided by MGI
Official Full Name
Rap guanine nucleotide exchange factor (GEF) 2provided by MGI
Primary source
MGI:MGI:2659071
See related
Ensembl:ENSMUSG00000062232 AllianceGenome:MGI:2659071
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Pdzgef1; nRapGEP; CNRasGEF; RA-GEF-1; mKIAA0313; 5830453M24Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in several processes, including cAMP-mediated signaling; cellular response to cAMP; and generation of neurons. Predicted to be located in several cellular components, including apical plasma membrane; bicellular tight junction; and cytoplasmic vesicle. Predicted to be part of protein-containing complex. Is expressed in embryo; olfactory epithelium; yolk sac endoderm; and yolk sac mesenchyme. Human ortholog(s) of this gene implicated in familial adult myoclonic epilepsy 7. Orthologous to human RAPGEF2 (Rap guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in frontal lobe adult (RPKM 10.4), cortex adult (RPKM 8.4) and 27 other tissues See more
Orthologs
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Genomic context

Location:
3 E3; 3 34.91 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (78969818..79194681, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (79062511..79286545, complement)

Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23440 Neighboring gene STARR-seq mESC enhancer starr_07990 Neighboring gene STARR-seq mESC enhancer starr_07991 Neighboring gene predicted gene, 52609 Neighboring gene STARR-positive B cell enhancer ABC_E2667 Neighboring gene RIKEN cDNA 4921511C10 gene Neighboring gene STARR-seq mESC enhancer starr_07993 Neighboring gene predicted gene, 24150 Neighboring gene RIKEN cDNA 6430573P05 gene Neighboring gene STARR-seq mESC enhancer starr_07995 Neighboring gene predicted gene, 40072 Neighboring gene sperm microtubule inner protein 2 Neighboring gene STARR-seq mESC enhancer starr_07997 Neighboring gene STARR-seq mESC enhancer starr_07998 Neighboring gene STARR-seq mESC enhancer starr_07999 Neighboring gene folliculin interacting protein 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables PDZ domain binding ISO
Inferred from Sequence Orthology
more info
 
enables WW domain binding ISO
Inferred from Sequence Orthology
more info
 
enables beta-1 adrenergic receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables phosphatidic acid binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in G protein-coupled receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Rap protein signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in Ras protein signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in blood vessel development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in brain-derived neurotrophic factor receptor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cAMP-mediated signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cAMP IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to cAMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to cGMP ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to nerve growth factor stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in establishment of endothelial intestinal barrier ISO
Inferred from Sequence Orthology
more info
 
involved_in forebrain neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in microvillus assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of dendrite morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of dendrite morphogenesis ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of melanin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in nerve growth factor signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
 
involved_in neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuropeptide signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of cAMP-dependent protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cAMP-dependent protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of dendritic cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron projection development ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of vasculogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization to plasma membrane ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of cell junction assembly ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of modification of postsynaptic structure IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of modification of postsynaptic structure IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in regulation of modification of postsynaptic structure IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 
involved_in ventricular system development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in bicellular tight junction ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
is_active_in endocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endocytic vesicle ISO
Inferred from Sequence Orthology
more info
 
located_in endosome IEA
Inferred from Electronic Annotation
more info
 
located_in late endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane ISO
Inferred from Sequence Orthology
more info
 
located_in neuron projection ISO
Inferred from Sequence Orthology
more info
 
located_in neuronal cell body ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 2
Names
PDZ domain-containing guanine nucleotide exchange factor 1
cyclic nucleotide ras GEF
neural RAP guanine nucleotide exchange protein
ras/Rap1-associating GEF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001099624.3NP_001093094.2  rap guanine nucleotide exchange factor 2 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform 1.
    Source sequence(s)
    AK147368, BC067056, BP758717
    Consensus CDS
    CCDS50932.1
    UniProtKB/TrEMBL
    E9QNQ4, Q6NXI4
    Related
    ENSMUSP00000113778.2, ENSMUST00000118340.7
    Conserved Domains (5) summary
    smart00100
    Location:134249
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:265378
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:711936
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:382462
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:604688
    UBQ; Ubiquitin-like proteins
  2. NM_001310536.2NP_001297465.2  rap guanine nucleotide exchange factor 2 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream in-frame start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus than isoform 1.
    Source sequence(s)
    AC124358, AC164560
    Consensus CDS
    CCDS89637.1
    UniProtKB/Swiss-Prot
    E9QMD0, Q8CHG7
    UniProtKB/TrEMBL
    Q6NXI4
    Related
    ENSMUSP00000114119.2, ENSMUST00000118100.8
    Conserved Domains (7) summary
    smart00100
    Location:136251
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:267380
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03379
    Location:13611482
    PHA03379; EBNA-3A; Provisional
    cd00155
    Location:713938
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:384464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:404528
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:608690
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  3. NM_001428995.1NP_001415924.1  rap guanine nucleotide exchange factor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC124358, AC157941, AC164560

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000069.7 Reference GRCm39 C57BL/6J

    Range
    78969818..79194681 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006502250.5XP_006502313.1  rap guanine nucleotide exchange factor 2 isoform X2

    UniProtKB/TrEMBL
    A0A0A6YWG7
    Conserved Domains (8) summary
    smart00100
    Location:291406
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:422535
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03379
    Location:15161637
    PHA03379; EBNA-3A; Provisional
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8681093
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:539619
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:559683
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:763845
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  2. XM_011240277.4XP_011238579.1  rap guanine nucleotide exchange factor 2 isoform X3

    UniProtKB/TrEMBL
    A0A0A6YWG7
    Conserved Domains (8) summary
    smart00100
    Location:297412
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:428541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03379
    Location:15141635
    PHA03379; EBNA-3A; Provisional
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8741078
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:545625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:565689
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:769851
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  3. XM_011240276.4XP_011238578.1  rap guanine nucleotide exchange factor 2 isoform X1

    UniProtKB/TrEMBL
    A0A0A6YWG7
    Related
    ENSMUSP00000141542.2, ENSMUST00000195708.2
    Conserved Domains (8) summary
    smart00100
    Location:297412
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:428541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03379
    Location:15221643
    PHA03379; EBNA-3A; Provisional
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8741099
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:545625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:565689
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:769851
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  4. XM_036163389.1XP_036019282.1  rap guanine nucleotide exchange factor 2 isoform X5

    UniProtKB/TrEMBL
    Q6NXI4
    Conserved Domains (6) summary
    smart00100
    Location:175290
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:306419
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03379
    Location:14001521
    PHA03379; EBNA-3A; Provisional
    cd00155
    Location:752977
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:423503
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01785
    Location:647729
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  5. XM_006502252.5XP_006502315.1  rap guanine nucleotide exchange factor 2 isoform X4

    UniProtKB/TrEMBL
    Q6NXI4
    Conserved Domains (7) summary
    smart00100
    Location:181296
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:312425
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03379
    Location:14061527
    PHA03379; EBNA-3A; Provisional
    cd00155
    Location:758983
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:429509
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:449573
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:653735
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  6. XM_030252869.2XP_030108729.1  rap guanine nucleotide exchange factor 2 isoform X6

    UniProtKB/TrEMBL
    Q6NXI4
    Conserved Domains (7) summary
    smart00100
    Location:117232
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:248361
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    PHA03379
    Location:13421463
    PHA03379; EBNA-3A; Provisional
    cd00155
    Location:694919
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:365445
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:385509
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:589671
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins