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RAPGEF2 Rap guanine nucleotide exchange factor 2 [ Homo sapiens (human) ]

Gene ID: 9693, updated on 4-Sep-2021

Summary

Official Symbol
RAPGEF2provided by HGNC
Official Full Name
Rap guanine nucleotide exchange factor 2provided by HGNC
Primary source
HGNC:HGNC:16854
See related
Ensembl:ENSG00000109756 MIM:609530
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAGEF; RA-GEF; NRAPGEP; PDZGEF1; Rap-GEP; CNrasGEF; PDZ-GEF1; RA-GEF-1; nRap GEP
Summary
Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in brain (RPKM 13.6), bone marrow (RPKM 11.0) and 25 other tissues See more
Orthologs
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Genomic context

See RAPGEF2 in Genome Data Viewer
Location:
4q32.1
Exon count:
35
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 4 NC_000004.12 (159103079..159360173)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (160025203..160281321)

Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene chromosome 4 open reading frame 45 Neighboring gene proteasome activator subunit 2 pseudogene 3 Neighboring gene fatty acid binding protein 5 pseudogene 12 Neighboring gene microRNA 3688-1 Neighboring gene microRNA 3688-2 Neighboring gene uncharacterized LOC107986324 Neighboring gene uncharacterized LOC105379457 Neighboring gene long intergenic non-protein coding RNA 2233

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTPase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables PDZ domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables WW domain binding IDA
Inferred from Direct Assay
more info
PubMed 
enables beta-1 adrenergic receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables cAMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cAMP binding IDA
Inferred from Direct Assay
more info
PubMed 
NOT enables cGMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables calcium ion binding NAS
Non-traceable Author Statement
more info
PubMed 
enables diacylglycerol binding NAS
Non-traceable Author Statement
more info
PubMed 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables phosphatidic acid binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in MAPK cascade NAS
Non-traceable Author Statement
more info
PubMed 
involved_in Rap protein signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in adenylate cyclase-activating adrenergic receptor signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in blood vessel development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in brain-derived neurotrophic factor receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cAMP-mediated signaling NAS
Non-traceable Author Statement
more info
PubMed 
involved_in cellular response to cAMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to cGMP IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to nerve growth factor stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in establishment of endothelial barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in establishment of endothelial intestinal barrier IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in forebrain neuron development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intracellular signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in microvillus assembly IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of dendrite morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of melanin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in nerve growth factor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuropeptide signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of GTPase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cAMP-dependent protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cAMP-mediated signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron migration ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of neuron projection development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of vasculogenesis ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell junction assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of synaptic plasticity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in small GTPase mediated signal transduction TAS
Traceable Author Statement
more info
PubMed 
involved_in ventricular system development ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in bicellular tight junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in cell-cell junction ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in endocytic vesicle IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane NAS
Non-traceable Author Statement
more info
PubMed 
located_in late endosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in neuronal cell body ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of protein-containing complex ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in synapse ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
rap guanine nucleotide exchange factor 2
Names
PDZ domain containing guanine nucleotide exchange factor (GEF) 1
PDZ domain-containing guanine nucleotide exchange factor 1
RA(Ras/Rap1A-associating)-GEF
Rap guanine nucleotide exchange factor (GEF) 2
cyclic nucleotide ras GEF
neural RAP guanine nucleotide exchange protein
ras/Rap1-associating GEF-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_063926.1 RefSeqGene

    Range
    4983..261105
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001351724.5NP_001338653.1  rap guanine nucleotide exchange factor 2 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC074344, AC095064, AC105316
    Related
    ENSP00000495906.1, ENST00000644474.1
    Conserved Domains (7) summary
    smart00100
    Location:297412
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:428541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8741099
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:545625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:565689
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:769851
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  2. NM_001351725.2NP_001338654.1  rap guanine nucleotide exchange factor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074344, AC105316
    Conserved Domains (6) summary
    smart00100
    Location:181296
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:312425
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:758983
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:429509
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:651735
    UBQ; Ubiquitin-like proteins
    cl28339
    Location:449573
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
  3. NM_001351726.3NP_001338655.1  rap guanine nucleotide exchange factor 2 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC074344, AC105316
    Conserved Domains (6) summary
    smart00100
    Location:181296
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:312425
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:758983
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:429509
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:651735
    UBQ; Ubiquitin-like proteins
    cl28339
    Location:449573
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
  4. NM_001351727.4NP_001338656.1  rap guanine nucleotide exchange factor 2 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC074344, AC105316
    Conserved Domains (6) summary
    smart00100
    Location:136251
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:267380
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:713938
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:384464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:404528
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:608690
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  5. NM_001351728.4NP_001338657.1  rap guanine nucleotide exchange factor 2 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC074344, AC105316
    Conserved Domains (6) summary
    smart00100
    Location:136251
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:267380
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:713938
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:384464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:404528
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:608690
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  6. NM_001394067.2NP_001380996.1  rap guanine nucleotide exchange factor 2 isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC074344, AC095064, AC105316
    Conserved Domains (6) summary
    smart00100
    Location:297412
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:428541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8741099
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:545625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cd01785
    Location:769851
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  7. NM_014247.5NP_055062.1  rap guanine nucleotide exchange factor 2 isoform 5

    See identical proteins and their annotated locations for NP_055062.1

    Status: VALIDATED

    Source sequence(s)
    AC074344, AC105316
    Consensus CDS
    CCDS43277.1
    UniProtKB/Swiss-Prot
    Q9Y4G8
    Related
    ENSP00000264431.4, ENST00000264431.8
    Conserved Domains (6) summary
    smart00100
    Location:136251
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:267380
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:713938
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:384464
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:404528
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:608690
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000004.12 Reference GRCh38.p13 Primary Assembly

    Range
    159103079..159360173
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005263358.3XP_005263415.1  rap guanine nucleotide exchange factor 2 isoform X1

    Conserved Domains (7) summary
    smart00100
    Location:297412
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:428541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8741099
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:545625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    TIGR02037
    Location:565689
    degP_htrA_DO; periplasmic serine protease, Do/DeqQ family
    cd01785
    Location:769851
    RA_PDZ-GEF1; Ras-associating (RA) domain found in PDZ domain-containing guanine nucleotide exchange factor 1 (PDZ-GEF1) and similar proteins
  2. XM_005263359.4XP_005263416.1  rap guanine nucleotide exchange factor 2 isoform X3

    Conserved Domains (7) summary
    smart00100
    Location:297412
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:428541
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    COG0664
    Location:31147
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8741078
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:545625
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:767851
    UBQ; Ubiquitin-like proteins
  3. XM_017008856.2XP_016864345.1  rap guanine nucleotide exchange factor 2 isoform X6

  4. XM_006714420.3XP_006714483.1  rap guanine nucleotide exchange factor 2 isoform X2

    Conserved Domains (7) summary
    smart00100
    Location:291406
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:422535
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    COG0664
    Location:31147
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8681093
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:539619
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:761845
    UBQ; Ubiquitin-like proteins
  5. XM_005263361.3XP_005263418.1  rap guanine nucleotide exchange factor 2 isoform X5

    Conserved Domains (7) summary
    smart00100
    Location:291406
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:422535
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    COG0664
    Location:31147
    Crp; cAMP-binding domain of CRP or a regulatory subunit of cAMP-dependent protein kinases [Signal transduction mechanisms]
    cd00038
    Location:37143
    CAP_ED; effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO ...
    cd00155
    Location:8681093
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:539619
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:761845
    UBQ; Ubiquitin-like proteins
  6. XM_006714422.4XP_006714485.1  rap guanine nucleotide exchange factor 2 isoform X8

    See identical proteins and their annotated locations for XP_006714485.1

    Conserved Domains (5) summary
    smart00100
    Location:181296
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:312425
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:758983
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:429509
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:651735
    UBQ; Ubiquitin-like proteins
  7. XM_024454286.1XP_024310054.1  rap guanine nucleotide exchange factor 2 isoform X9

    Conserved Domains (6) summary
    smart00100
    Location:175290
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:306419
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:752977
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:423503
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:645729
    UBQ; Ubiquitin-like proteins
    cl28339
    Location:443567
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
  8. XM_011532426.2XP_011530728.1  rap guanine nucleotide exchange factor 2 isoform X8

    See identical proteins and their annotated locations for XP_011530728.1

    Conserved Domains (5) summary
    smart00100
    Location:181296
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:312425
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:758983
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:429509
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:651735
    UBQ; Ubiquitin-like proteins
  9. XM_024454287.1XP_024310055.1  rap guanine nucleotide exchange factor 2 isoform X9

    Conserved Domains (6) summary
    smart00100
    Location:175290
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:306419
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:752977
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:423503
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:645729
    UBQ; Ubiquitin-like proteins
    cl28339
    Location:443567
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
  10. XM_011532425.2XP_011530727.1  rap guanine nucleotide exchange factor 2 isoform X7

    Related
    ENSP00000495298.1, ENST00000644902.1
    Conserved Domains (5) summary
    smart00100
    Location:185300
    cNMP; Cyclic nucleotide-monophosphate binding domain
    smart00229
    Location:316429
    RasGEFN; Guanine nucleotide exchange factor for Ras-like GTPases; N-terminal motif
    cd00155
    Location:762987
    RasGEF; Guanine nucleotide exchange factor for Ras-like small GTPases. Small GTP-binding proteins of the Ras superfamily function as molecular switches in fundamental events such as signal transduction, cytoskeleton dynamics and intracellular trafficking. ...
    cd00992
    Location:433513
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    cl00155
    Location:655739
    UBQ; Ubiquitin-like proteins
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