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ZBTB25 zinc finger and BTB domain containing 25 [ Homo sapiens (human) ]

Gene ID: 7597, updated on 5-Aug-2022

Summary

Official Symbol
ZBTB25provided by HGNC
Official Full Name
zinc finger and BTB domain containing 25provided by HGNC
Primary source
HGNC:HGNC:13112
See related
Ensembl:ENSG00000089775 MIM:194541; AllianceGenome:HGNC:13112
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KUP; ZNF46; C14orf51
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in liver (RPKM 4.4), thyroid (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZBTB25 in Genome Data Viewer
Location:
14q23.3
Exon count:
10
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (64449106..64505213, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (58656859..58712973, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (64915824..64971931, complement)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene testis expressed 21, pseudogene Neighboring gene methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1 Neighboring gene Sharpr-MPRA regulatory region 9441 Neighboring gene A-kinase anchoring protein 5 Neighboring gene HSPA2 and ZBTB1 antisense RNA 1 Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene heat shock protein family A (Hsp70) member 2 Neighboring gene protein phosphatase 1 regulatory subunit 36

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity TAS
Traceable Author Statement
more info
PubMed 
enables DNA-binding transcription repressor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 25
Names
zinc finger protein 46
zinc finger protein KUP

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304507.1NP_001291436.1  zinc finger and BTB domain-containing protein 25 isoform a

    See identical proteins and their annotated locations for NP_001291436.1

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AK098181, AL049869, BC014650, BQ446833, BX479957, DA328137
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    P24278, Q8IYH9
    Related
    ENSP00000378204.1, ENST00000394715.1
    Conserved Domains (3) summary
    sd00019
    Location:240260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14114
    BTB; BTB/POZ domain
  2. NM_001304508.1NP_001291437.1  zinc finger and BTB domain-containing protein 25 isoform b

    Status: VALIDATED

    Source sequence(s)
    AL049869, BC014650
    Consensus CDS
    CCDS76689.1
    UniProtKB/TrEMBL
    G3V2K3
    Related
    ENSP00000450718.1, ENST00000555220.5
    Conserved Domains (1) summary
    pfam00651
    Location:1460
    BTB; BTB/POZ domain
  3. NM_001354682.2NP_001341611.1  zinc finger and BTB domain-containing protein 25 isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (c).
    Source sequence(s)
    AL049869, AL122035
    Conserved Domains (3) summary
    sd00019
    Location:279299
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:279299
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:53153
    BTB; BTB/POZ domain
  4. NM_001354683.2NP_001341612.1  zinc finger and BTB domain-containing protein 25 isoform d

    Status: VALIDATED

    Source sequence(s)
    AL049869
    Conserved Domains (3) summary
    sd00019
    Location:240260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14114
    BTB; BTB/POZ domain
  5. NM_001354684.2NP_001341613.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14114
    BTB; BTB/POZ domain
  6. NM_001354685.2NP_001341614.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14114
    BTB; BTB/POZ domain
  7. NM_001354686.2NP_001341615.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14114
    BTB; BTB/POZ domain
  8. NM_001354687.2NP_001341616.1  zinc finger and BTB domain-containing protein 25 isoform a

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    Q8IYH9
    Conserved Domains (3) summary
    sd00019
    Location:240260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14114
    BTB; BTB/POZ domain
  9. NM_006977.5NP_008908.2  zinc finger and BTB domain-containing protein 25 isoform a

    See identical proteins and their annotated locations for NP_008908.2

    Status: VALIDATED

    Description
    Transcript Variant: Variants 1, 2, 6, 7, 8 and 9 encode the same isoform (a).
    Source sequence(s)
    AL049869, AL122035, BC035804, BQ446833, BX479957, DA328137
    Consensus CDS
    CCDS9765.1
    UniProtKB/Swiss-Prot
    P24278, Q8IYH9
    Related
    ENSP00000476746.1, ENST00000608382.6
    Conserved Domains (3) summary
    sd00019
    Location:240260
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:240260
    zf-C2H2; Zinc finger, C2H2 type
    pfam00651
    Location:14114
    BTB; BTB/POZ domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    64449106..64505213 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047431770.1XP_047287726.1  zinc finger and BTB domain-containing protein 25 isoform X1

RNA

  1. XR_943522.4 RNA Sequence

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    58656859..58712973 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)