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Zbtb25 zinc finger and BTB domain containing 25 [ Mus musculus (house mouse) ]

Gene ID: 109929, updated on 8-Dec-2022

Summary

Official Symbol
Zbtb25provided by MGI
Official Full Name
zinc finger and BTB domain containing 25provided by MGI
Primary source
MGI:MGI:99197
See related
Ensembl:ENSMUSG00000056459 AllianceGenome:MGI:99197
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Kup; Zfp50; Zfp-50; 2810462M08Rik; 2900064P18Rik
Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleoplasm. Is expressed in genitourinary system. Orthologous to human ZBTB25 (zinc finger and BTB domain containing 25). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 3.3), limb E14.5 (RPKM 3.0) and 28 other tissues See more
Orthologs
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Genomic context

See Zbtb25 in Genome Data Viewer
Location:
12 C3; 12 33.73 cM
Exon count:
7
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (76387168..76416988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (76348900..76370214, complement)

Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene methylenetetrahydrofolate dehydrogenase (NADP+ dependent), methenyltetrahydrofolate cyclohydrolase, formyltetrahydrofolate synthase Neighboring gene predicted gene, 40443 Neighboring gene A kinase (PRKA) anchor protein 5 Neighboring gene RIKEN cDNA 4930426I24 gene Neighboring gene zinc finger and BTB domain containing 1 Neighboring gene heat shock protein 2 Neighboring gene protein phosphatase 1, regulatory subunit 36 Neighboring gene predicted gene, 25563

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Endonuclease-mediated (2) 

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of cytokine production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of immune system process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
zinc finger and BTB domain-containing protein 25
Names
zinc finger protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001172104.1NP_001165575.1  zinc finger and BTB domain-containing protein 25

    See identical proteins and their annotated locations for NP_001165575.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124453
    Consensus CDS
    CCDS25991.2
    UniProtKB/TrEMBL
    G3UW50
    Related
    ENSMUSP00000128471.2, ENSMUST00000167011.8
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  2. NM_028356.2NP_082632.2  zinc finger and BTB domain-containing protein 25

    See identical proteins and their annotated locations for NP_082632.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AC124453
    Consensus CDS
    CCDS25991.2
    UniProtKB/TrEMBL
    G3UW50
    Related
    ENSMUSP00000134748.2, ENSMUST00000176278.8
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000078.7 Reference GRCm39 C57BL/6J

    Range
    76387168..76416988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017314936.3XP_017170425.2  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128148
    zf-C2H2; Zinc finger, C2H2 type
  2. XM_006515397.3XP_006515460.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515460.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  3. XM_030246520.2XP_030102380.1  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128148
    zf-C2H2; Zinc finger, C2H2 type
  4. XM_030246517.2XP_030102377.1  zinc finger and BTB domain-containing protein 25 isoform X2

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  5. XM_030246519.2XP_030102379.1  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128148
    zf-C2H2; Zinc finger, C2H2 type
  6. XM_006515396.3XP_006515459.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515459.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  7. XM_030246518.2XP_030102378.1  zinc finger and BTB domain-containing protein 25 isoform X3

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128148
    zf-C2H2; Zinc finger, C2H2 type
  8. XM_006515400.3XP_006515463.1  zinc finger and BTB domain-containing protein 25 isoform X3

    See identical proteins and their annotated locations for XP_006515463.1

    UniProtKB/TrEMBL
    Q6NV93
    Conserved Domains (2) summary
    sd00018
    Location:126148
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:128148
    zf-C2H2; Zinc finger, C2H2 type
  9. XM_006515394.3XP_006515457.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515457.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  10. XM_006515393.3XP_006515456.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515456.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  11. XM_030246516.2XP_030102376.1  zinc finger and BTB domain-containing protein 25 isoform X2

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  12. XM_006515399.3XP_006515462.1  zinc finger and BTB domain-containing protein 25 isoform X2

    See identical proteins and their annotated locations for XP_006515462.1

    UniProtKB/TrEMBL
    G3UW50
    Conserved Domains (3) summary
    sd00018
    Location:239261
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:241261
    zf-C2H2; Zinc finger, C2H2 type
    cd18213
    Location:3130
    BTB_POZ_ZBTB25_ZNF46_KUP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in zinc finger and BTB domain-containing protein 25 (ZBTB25)
  13. XM_006515392.5XP_006515455.1  zinc finger and BTB domain-containing protein 25 isoform X1

    Conserved Domains (5) summary
    smart00355
    Location:548568
    ZnF_C2H2; zinc finger
    PHA03307
    Location:2250
    PHA03307; transcriptional regulator ICP4; Provisional
    sd00018
    Location:432454
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434454
    zf-C2H2; Zinc finger, C2H2 type
    cl38908
    Location:249323
    BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily