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ZNF45 zinc finger protein 45 [ Homo sapiens (human) ]

Gene ID: 7596, updated on 8-Jul-2021

Summary

Official Symbol
ZNF45provided by HGNC
Official Full Name
zinc finger protein 45provided by HGNC
Primary source
HGNC:HGNC:13111
See related
Ensembl:ENSG00000124459 MIM:194554
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX5; ZNF13
Expression
Ubiquitous expression in thyroid (RPKM 3.8), ovary (RPKM 3.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF45 in Genome Data Viewer
Location:
19q13.31
Exon count:
12
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (43912624..43935315, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (44416776..44439434, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 404 Neighboring gene uncharacterized LOC100505715 Neighboring gene ZNF45 antisense RNA 1 Neighboring gene zinc finger protein 221 Neighboring gene zinc finger protein 155 Neighboring gene ZNF230 divergent transcript

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
The correlation between reading and mathematics ability at age twelve has a substantial genetic component.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in multicellular organism development TAS
Traceable Author Statement
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 45
Names
BRC1744
zinc finger protein 13
zinc finger protein 45 (a Kruppel-associated box (KRAB) domain polypeptide)
zinc finger protein KOX5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003425.4NP_003416.1  zinc finger protein 45

    See identical proteins and their annotated locations for NP_003416.1

    Status: VALIDATED

    Source sequence(s)
    AC006213
    Consensus CDS
    CCDS12632.1
    UniProtKB/Swiss-Prot
    Q02386
    Related
    ENSP00000269973.4, ENST00000269973.10
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    43912624..43935315 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027227.2XP_016882716.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Related
    ENSP00000481895.1, ENST00000615985.4
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017027226.2XP_016882715.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  3. XM_017027225.2XP_016882714.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017027220.2XP_016882709.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  5. XM_024451691.1XP_024307459.1  zinc finger protein 45 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:133506
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:460571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550570
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:590614
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  6. XM_011527271.1XP_011525573.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525573.1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  7. XM_024451692.1XP_024307460.1  zinc finger protein 45 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:133506
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:460571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550570
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:590614
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  8. XM_011527273.1XP_011525575.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525575.1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  9. XM_011527269.1XP_011525571.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525571.1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  10. XM_017027218.1XP_016882707.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  11. XM_017027228.1XP_016882717.1  zinc finger protein 45 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:133506
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:460571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550570
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:590614
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  12. XM_017027219.1XP_016882708.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  13. XM_011527267.1XP_011525569.1  zinc finger protein 45 isoform X1

    See identical proteins and their annotated locations for XP_011525569.1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  14. XM_017027222.1XP_016882711.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  15. XM_017027217.1XP_016882706.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  16. XM_017027224.2XP_016882713.1  zinc finger protein 45 isoform X1

    UniProtKB/Swiss-Prot
    Q02386
    Conserved Domains (6) summary
    smart00349
    Location:867
    KRAB; krueppel associated box
    COG5048
    Location:190602
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:586606
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:584606
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:319343
    zf-H2C2_2; Zinc-finger double domain
  17. XM_017027230.1XP_016882719.1  zinc finger protein 45 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:133506
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:460571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550570
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:590614
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  18. XM_024451690.1XP_024307458.1  zinc finger protein 45 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:133506
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:460571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550570
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:590614
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
  19. XM_017027229.2XP_016882718.1  zinc finger protein 45 isoform X2

    Conserved Domains (5) summary
    COG5048
    Location:133506
    COG5048; FOG: Zn-finger [General function prediction only]
    COG5189
    Location:460571
    SFP1; Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning]
    sd00017
    Location:550570
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:590614
    zf-H2C2_2; Zinc-finger double domain
    cl02581
    Location:131
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
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