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ZNF37A zinc finger protein 37A [ Homo sapiens (human) ]

Gene ID: 7587, updated on 1-Jun-2020

Summary

Official Symbol
ZNF37Aprovided by HGNC
Official Full Name
zinc finger protein 37Aprovided by HGNC
Primary source
HGNC:HGNC:13102
See related
Ensembl:ENSG00000075407 MIM:616085
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KOX21; ZNF37
Expression
Ubiquitous expression in thyroid (RPKM 3.1), endometrium (RPKM 2.4) and 25 other tissues See more
Orthologs

Genomic context

See ZNF37A in Genome Data Viewer
Location:
10p11.1
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (38094327..38150293)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (38383264..38412280)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene eukaryotic translation initiation factor 3 subunit L pseudogene 3 Neighboring gene FXYD domain containing ion transport regulator 6 pseudogene 2 Neighboring gene uncharacterized LOC105376500 Neighboring gene cyclin Y like 4 (pseudogene)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • FLJ3472

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
nucleus NAS
Non-traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 37A
Names
zinc finger protein 37a (KOX 21)
zinc finger protein KOX21

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001007094.2NP_001007095.1  zinc finger protein 37A isoform a

    See identical proteins and their annotated locations for NP_001007095.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AA742606, AL117339, AL708537, BX647089
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Related
    ENSP00000329141.3, ENST00000351773.7
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001178101.2NP_001171572.1  zinc finger protein 37A isoform a

    See identical proteins and their annotated locations for NP_001171572.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an internal segment and uses a different splice site in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same protein.
    Source sequence(s)
    AA742606, AJ492195, AK092012, AL117339, AL708537
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  3. NM_001324245.2NP_001311174.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4), as well as variants 1-3 and 5-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  4. NM_001324246.2NP_001311175.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5), as well as variants 1-4 and 6-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  5. NM_001324247.2NP_001311176.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6), as well as variants 1-5 and 7-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  6. NM_001324248.2NP_001311177.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7), as well as variants 1-6 and 8-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  7. NM_001324249.2NP_001311178.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8), as well as variants 1-7 and 9-10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  8. NM_001324250.2NP_001311179.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9), as well as variants 1-8 and 10, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  9. NM_001324251.2NP_001311180.1  zinc finger protein 37A isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10), as well as variants 1-9, encodes isoform a.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  10. NM_001324252.1NP_001311181.1  zinc finger protein 37A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11), as well as variants 12 and 13, encodes isoform b.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  11. NM_001324253.1NP_001311182.1  zinc finger protein 37A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12), as well as variants 11 and 13, encodes isoform b.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  12. NM_001324254.1NP_001311183.1  zinc finger protein 37A isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13), as well as variants 11 and 12, encodes isoform b.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  13. NM_001324256.2NP_001311185.1  zinc finger protein 37A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14), as well as variants 15-16, encodes isoform c.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS81451.1
    UniProtKB/TrEMBL
    A0A1B0GVV4
    Related
    ENSP00000490669.1, ENST00000638053.1
  14. NM_001324257.2NP_001311186.1  zinc finger protein 37A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variants 14 and 16, encodes isoform c.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS81451.1
    UniProtKB/TrEMBL
    A0A1B0GVV4
  15. NM_001324258.2NP_001311187.1  zinc finger protein 37A isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variants 14-15, encodes isoform c.
    Source sequence(s)
    AL117339
    Consensus CDS
    CCDS81451.1
    UniProtKB/TrEMBL
    A0A1B0GVV4
  16. NM_001324259.2NP_001311188.1  zinc finger protein 37A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (17) and variant 18 both encode isoform d.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  17. NM_001324260.2NP_001311189.1  zinc finger protein 37A isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (18) and variant 17 both encode isoform d.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  18. NM_001324261.2NP_001311190.1  zinc finger protein 37A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (19) and variant 20 both encode isoform e.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  19. NM_001324262.2NP_001311191.1  zinc finger protein 37A isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (20) and variant 19 both encode isoform e.
    Source sequence(s)
    AL117339
    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  20. NM_003421.3NP_003412.1  zinc finger protein 37A isoform a

    See identical proteins and their annotated locations for NP_003412.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an internal segment in the 5' UTR, compared to variant 1. Variants 1-10 all encode the same isoform (a).
    Source sequence(s)
    AA742606, AK092012, AL117339, AL708537
    Consensus CDS
    CCDS31183.1
    UniProtKB/Swiss-Prot
    P17032
    Related
    ENSP00000354377.4, ENST00000361085.9
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    38094327..38150293
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016619.1XP_016872108.1  zinc finger protein 37A isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:55471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:211231
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307331
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017016621.1XP_016872110.1  zinc finger protein 37A isoform X3

    UniProtKB/TrEMBL
    A0A1B0GVV4
  3. XM_017016618.1XP_016872107.1  zinc finger protein 37A isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:55471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:211231
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307331
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017016622.1XP_016872111.1  zinc finger protein 37A isoform X4

    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  5. XM_017016624.1XP_016872113.1  zinc finger protein 37A isoform X6

    Related
    ENST00000479469.5
  6. XM_017016623.1XP_016872112.1  zinc finger protein 37A isoform X5

    Conserved Domains (1) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
  7. XM_011519658.3XP_011517960.1  zinc finger protein 37A isoform X1

    See identical proteins and their annotated locations for XP_011517960.1

    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  8. XM_011519656.2XP_011517958.1  zinc finger protein 37A isoform X1

    See identical proteins and their annotated locations for XP_011517958.1

    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  9. XM_011519657.2XP_011517959.1  zinc finger protein 37A isoform X1

    See identical proteins and their annotated locations for XP_011517959.1

    UniProtKB/Swiss-Prot
    P17032
    Conserved Domains (4) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:269421
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:301321
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:426448
    zf-H2C2_2; Zinc-finger double domain
  10. XM_005252586.4XP_005252643.1  zinc finger protein 37A isoform X2

    See identical proteins and their annotated locations for XP_005252643.1

    Conserved Domains (3) summary
    COG5048
    Location:55471
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:211231
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:307331
    zf-H2C2_2; Zinc-finger double domain
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