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ZNF16 zinc finger protein 16 [ Homo sapiens (human) ]

Gene ID: 7564, updated on 5-Jan-2022

Summary

Official Symbol
ZNF16provided by HGNC
Official Full Name
zinc finger protein 16provided by HGNC
Primary source
HGNC:HGNC:12947
See related
Ensembl:ENSG00000170631 MIM:601262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HZF1; KOX9
Summary
The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Expression
Ubiquitous expression in ovary (RPKM 5.1), testis (RPKM 4.3) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF16 in Genome Data Viewer
Location:
8q24.3
Exon count:
5
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 8 NC_000008.11 (144930358..144950880, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (146155744..146176266, complement)

Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene zinc finger protein 7 Neighboring gene COMM domain containing 5 Neighboring gene zinc finger protein 250 Neighboring gene zinc finger protein 252, pseudogene Neighboring gene ZNF252P antisense RNA 1 Neighboring gene transmembrane p24 trafficking protein 10 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 16
Names
zinc finger protein KOX9
zinc finger protein Kruppel type 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001029976.3NP_001025147.2  zinc finger protein 16

    See identical proteins and their annotated locations for NP_001025147.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) represents the longer transcript variant and encodes the same protein, as compared to transcript variant 1.
    Source sequence(s)
    BC010996, DQ117529
    Consensus CDS
    CCDS6437.1
    UniProtKB/Swiss-Prot
    P17020
    Related
    ENSP00000276816.4, ENST00000276816.8
    Conserved Domains (2) summary
    COG5048
    Location:303675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323343
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_006958.3NP_008889.2  zinc finger protein 16

    See identical proteins and their annotated locations for NP_008889.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) lacks an alternate exon in the 5' UTR and encodes the same protein, as compared to transcript variant 2.
    Source sequence(s)
    AF244088, AK127625
    Consensus CDS
    CCDS6437.1
    UniProtKB/Swiss-Prot
    P17020
    Related
    ENSP00000378369.2, ENST00000394909.7
    Conserved Domains (2) summary
    COG5048
    Location:303675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323343
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000008.11 Reference GRCh38.p13 Primary Assembly

    Range
    144930358..144950880 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272342.2XP_005272399.1  zinc finger protein 16 isoform X2

    Conserved Domains (3) summary
    COG5048
    Location:151502
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:183203
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam13465
    Location:251276
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011517298.1XP_011515600.1  zinc finger protein 16 isoform X1

    See identical proteins and their annotated locations for XP_011515600.1

    UniProtKB/Swiss-Prot
    P17020
    Conserved Domains (2) summary
    COG5048
    Location:303675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323343
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_024447267.1XP_024303035.1  zinc finger protein 16 isoform X1

    Conserved Domains (2) summary
    COG5048
    Location:303675
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:323343
    ZF_C2H2; C2H2 Zn finger [structural motif]
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