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ZNF711 zinc finger protein 711 [ Homo sapiens (human) ]

Gene ID: 7552, updated on 22-Aug-2021

Summary

Official Symbol
ZNF711provided by HGNC
Official Full Name
zinc finger protein 711provided by HGNC
Primary source
HGNC:HGNC:13128
See related
Ensembl:ENSG00000147180 MIM:314990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF4; ZNF5; ZNF6; CMPX1; MRX65; MRX97; XLID97; Zfp711; dJ75N13.1
Summary
This gene encodes a zinc finger protein of unknown function. It bears similarity to a zinc finger protein which acts as a transcriptional activator. This gene lies in a region of the X chromosome which has been associated with cognitive disability. [provided by RefSeq, Jul 2008]
Expression
Broad expression in testis (RPKM 23.7), brain (RPKM 10.7) and 16 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See ZNF711 in Genome Data Viewer
Location:
Xq21.1
Exon count:
10
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) X NC_000023.11 (85243820..85273362)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (84498997..84528363)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein O like Neighboring gene spermidine/spermine N1-acetyl transferase like 1 Neighboring gene uncharacterized LOC101928128 Neighboring gene POF1B actin binding protein Neighboring gene microRNA 1321

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
ZNF711-Related X-linked Mental Retardation
MedGen: C2749020 OMIM: 300803 GeneReviews: Not available
Compare labs

Copy number response

Description
Copy number response
Triplosensitivity

No evidence available (Last evaluated 2013-08-29)

ClinGen Genome Curation Page
Haploinsufficency

Some evidence for dosage pathogenicity (Last evaluated 2013-08-29)

ClinGen Genome Curation PagePubMed

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 711
Names
dJ75N13.1 (znf6-like)
mental retardation, X-linked 65
zinc finger protein 6 (CMPX1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012535.1 RefSeqGene

    Range
    5001..34367
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001330574.2NP_001317503.1  zinc finger protein 711 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC003001
    Consensus CDS
    CCDS83481.1
    UniProtKB/Swiss-Prot
    Q9Y462
    Related
    ENSP00000502839.1, ENST00000674551.1
    Conserved Domains (4) summary
    COG5048
    Location:546803
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65414
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  2. NM_001375431.1NP_001362360.1  zinc finger protein 711 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC003001
    Conserved Domains (4) summary
    COG5048
    Location:546803
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65414
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  3. NM_001375432.1NP_001362361.1  zinc finger protein 711 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC003001
    Conserved Domains (4) summary
    COG5048
    Location:546803
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65414
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  4. NM_001375433.1NP_001362362.1  zinc finger protein 711 isoform 1

    Status: REVIEWED

    Source sequence(s)
    AC003001
    Related
    ENSP00000353922.4, ENST00000360700.4
    Conserved Domains (4) summary
    COG5048
    Location:546803
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65414
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  5. NM_001375434.1NP_001362363.1  zinc finger protein 711 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC003001
    Conserved Domains (4) summary
    COG5048
    Location:500757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65368
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  6. NM_001375435.1NP_001362364.1  zinc finger protein 711 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC003001
    Conserved Domains (4) summary
    COG5048
    Location:500757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65368
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  7. NM_001375436.1NP_001362365.1  zinc finger protein 711 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC003001
    Conserved Domains (4) summary
    COG5048
    Location:500757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65368
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  8. NM_001375437.1NP_001362366.1  zinc finger protein 711 isoform 2

    Status: REVIEWED

    Source sequence(s)
    AC003001
    Related
    ENSP00000276123.3, ENST00000276123.7
    Conserved Domains (4) summary
    COG5048
    Location:500757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65368
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  9. NM_021998.5NP_068838.3  zinc finger protein 711 isoform 2

    See identical proteins and their annotated locations for NP_068838.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
    Source sequence(s)
    BC006349, BC067294, DB074057
    Consensus CDS
    CCDS35344.1
    UniProtKB/Swiss-Prot
    Q9Y462
    UniProtKB/TrEMBL
    Q6PK66
    Related
    ENSP00000362260.3, ENST00000373165.7
    Conserved Domains (4) summary
    COG5048
    Location:500757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65368
    Zfx_Zfy_act; Zfx / Zfy transcription activation region

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p13 Primary Assembly

    Range
    85243820..85273362
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011531019.1XP_011529321.1  zinc finger protein 711 isoform X1

    See identical proteins and their annotated locations for XP_011529321.1

    Conserved Domains (5) summary
    COG5048
    Location:550807
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:555577
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:69418
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:569593
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011531025.1XP_011529327.1  zinc finger protein 711 isoform X3

    Conserved Domains (5) summary
    COG5048
    Location:504761
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:511531
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:509531
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:69372
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:523547
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011531021.1XP_011529323.1  zinc finger protein 711 isoform X1

    See identical proteins and their annotated locations for XP_011529323.1

    Conserved Domains (5) summary
    COG5048
    Location:550807
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:555577
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:69418
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:569593
    zf-H2C2_2; Zinc-finger double domain
  4. XM_011531020.1XP_011529322.1  zinc finger protein 711 isoform X1

    See identical proteins and their annotated locations for XP_011529322.1

    Conserved Domains (5) summary
    COG5048
    Location:550807
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:555577
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:69418
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:569593
    zf-H2C2_2; Zinc-finger double domain
  5. XM_011531022.1XP_011529324.1  zinc finger protein 711 isoform X1

    See identical proteins and their annotated locations for XP_011529324.1

    Conserved Domains (5) summary
    COG5048
    Location:550807
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:555577
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:69418
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:569593
    zf-H2C2_2; Zinc-finger double domain
  6. XM_005262187.1XP_005262244.1  zinc finger protein 711 isoform X2

    See identical proteins and their annotated locations for XP_005262244.1

    UniProtKB/Swiss-Prot
    Q9Y462
    Conserved Domains (4) summary
    COG5048
    Location:546803
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65414
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  7. XM_005262188.1XP_005262245.1  zinc finger protein 711 isoform X2

    See identical proteins and their annotated locations for XP_005262245.1

    UniProtKB/Swiss-Prot
    Q9Y462
    Conserved Domains (4) summary
    COG5048
    Location:546803
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:553573
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:429451
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65414
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  8. XM_017029809.1XP_016885298.1  zinc finger protein 711 isoform X4

    UniProtKB/Swiss-Prot
    Q9Y462
    Conserved Domains (4) summary
    COG5048
    Location:500757
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:507527
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:383405
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:65368
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
  9. XM_011531023.3XP_011529325.1  zinc finger protein 711 isoform X1

    See identical proteins and their annotated locations for XP_011529325.1

    Conserved Domains (5) summary
    COG5048
    Location:550807
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:555577
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:69418
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:569593
    zf-H2C2_2; Zinc-finger double domain
  10. XM_017029803.1XP_016885292.1  zinc finger protein 711 isoform X1

    Conserved Domains (5) summary
    COG5048
    Location:550807
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:557577
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:555577
    zf-C2H2; Zinc finger, C2H2 type
    pfam04704
    Location:69418
    Zfx_Zfy_act; Zfx / Zfy transcription activation region
    pfam13465
    Location:569593
    zf-H2C2_2; Zinc-finger double domain
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