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PTTG1IP PTTG1 interacting protein [ Homo sapiens (human) ]

Gene ID: 754, updated on 7-Jun-2020

Summary

Official Symbol
PTTG1IPprovided by HGNC
Official Full Name
PTTG1 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:13524
See related
Ensembl:ENSG00000183255 MIM:603784
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBF; C21orf1; C21orf3
Summary
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in placenta (RPKM 104.1), gall bladder (RPKM 88.0) and 25 other tissues See more
Orthologs

Genomic context

See PTTG1IP in Genome Data Viewer
Location:
21q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 21 NC_000021.9 (44849585..44873903, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46269500..46294487, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1424 Neighboring gene small ubiquitin like modifier 3 Neighboring gene integrin subunit beta 2 Neighboring gene uncharacterized LOC107987303 Neighboring gene ITGB2 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
molecular_function ND
No biological Data available
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular exosome HDA PubMed 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
pituitary tumor-transforming gene 1 protein-interacting protein
Names
PTTG-binding factor
pituitary tumor-transforming 1 interacting protein
pituitary tumor-transforming gene protein-binding factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033966.1 RefSeqGene

    Range
    5214..29306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286822.1NP_001273751.1  pituitary tumor-transforming gene 1 protein-interacting protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001273751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks 3 consecutive exons, which cause a frame-shift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK298557, BC019295, BG721942, CB109980, DC396020
    Consensus CDS
    CCDS68221.1
    UniProtKB/Swiss-Prot
    P53801
    UniProtKB/TrEMBL
    B4DPZ0
    Related
    ENSP00000395374.2, ENST00000445724.3
  2. NM_004339.4NP_004330.1  pituitary tumor-transforming gene 1 protein-interacting protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_004330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC019295, BG721942
    Consensus CDS
    CCDS13715.1
    UniProtKB/Swiss-Prot
    P53801
    Related
    ENSP00000328325.3, ENST00000330938.8

RNA

  1. NR_104597.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the mid-region compared to variant 1. It is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC019295, BG721942, CB109980, CN295711, DC396020

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p13 Primary Assembly

    Range
    44849585..44873903 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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