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PTTG1IP PTTG1 interacting protein [ Homo sapiens (human) ]

Gene ID: 754, updated on 10-Dec-2024

Summary

Official Symbol
PTTG1IPprovided by HGNC
Official Full Name
PTTG1 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:13524
See related
Ensembl:ENSG00000183255 MIM:603784; AllianceGenome:HGNC:13524
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PBF; C21orf1; C21orf3; PTTG1IP1
Summary
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Expression
Ubiquitous expression in placenta (RPKM 104.1), gall bladder (RPKM 88.0) and 25 other tissues See more
Orthologs
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Genomic context

See PTTG1IP in Genome Data Viewer
Location:
21q22.3
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (44849598..44873690, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (43210435..43234444, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (46269513..46293605, complement)

Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13388 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:46227083-46227236 Neighboring gene long intergenic non-protein coding RNA 1424 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46235315-46235829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13390 Neighboring gene small ubiquitin like modifier 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13391 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46243688-46244247 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46254495-46254996 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46265244-46265744 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46265745-46266245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46282185-46282898 Neighboring gene uncharacterized LOC124905039 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18577 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18578 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46292726-46293226 Neighboring gene H3K27ac hESC enhancer GRCh37_chr21:46293227-46293727 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46293885-46294562 Neighboring gene Sharpr-MPRA regulatory region 2317 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46317333-46317948 Neighboring gene integrin subunit beta 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46326258-46326823 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46326824-46327388 Neighboring gene uncharacterized LOC107987303 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46329075-46329574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18580 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46333656-46334156 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13394 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:46337409-46338321 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13395 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr21:46345923-46346812 Neighboring gene ITGB2 antisense RNA 1 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr21:46347045-46348244 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18581

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

General protein information

Preferred Names
pituitary tumor-transforming gene 1 protein-interacting protein
Names
PTTG-binding factor
pituitary tumor-transforming 1 interacting protein
pituitary tumor-transforming gene protein-binding factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_033966.1 RefSeqGene

    Range
    5214..29306
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001286822.2NP_001273751.1  pituitary tumor-transforming gene 1 protein-interacting protein isoform 2 precursor

    See identical proteins and their annotated locations for NP_001273751.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks 3 consecutive exons, which cause a frame-shift compared to variant 1. The resulting shorter isoform (2) has a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK298557, BC019295
    Consensus CDS
    CCDS68221.1
    UniProtKB/TrEMBL
    B4DDS6, B4DPZ0
    Related
    ENSP00000395374.2, ENST00000445724.3
  2. NM_004339.4NP_004330.1  pituitary tumor-transforming gene 1 protein-interacting protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_004330.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC019295, BG721942
    Consensus CDS
    CCDS13715.1
    UniProtKB/Swiss-Prot
    B2RDP7, D3DSL9, P53801, Q9NS09
    UniProtKB/TrEMBL
    A8K274
    Related
    ENSP00000328325.3, ENST00000330938.8

RNA

  1. NR_104597.2 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon in the mid-region compared to variant 1. It is represented as non-coding because the use of the supported translational start codon, as used in variant 1, renders this transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    BC019295, BG721942, CN295711

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

    Range
    44849598..44873690 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060945.1 Alternate T2T-CHM13v2.0

    Range
    43210435..43234444 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)