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Pttg1ip pituitary tumor-transforming 1 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 108705, updated on 5-Mar-2024

Summary

Official Symbol
Pttg1ipprovided by MGI
Official Full Name
pituitary tumor-transforming 1 interacting proteinprovided by MGI
Primary source
MGI:MGI:2652132
See related
Ensembl:ENSMUSG00000009291 AllianceGenome:MGI:2652132
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
PBF; 1810010L20Rik
Summary
Predicted to enable p53 binding activity. Predicted to be involved in protein import into nucleus. Predicted to act upstream of or within negative regulation of signal transduction by p53 class mediator and positive regulation of cellular protein metabolic process. Predicted to be located in nucleoplasm. Predicted to be active in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; cardiovascular system; genitourinary system; nervous system; and sensory organ. Orthologous to human PTTG1IP (PTTG1 interacting protein). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bladder adult (RPKM 114.2), kidney adult (RPKM 87.1) and 28 other tissues See more
Orthologs
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Genomic context

Location:
10 C1; 10 39.72 cM
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (77417489..77434566)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (77581655..77598732)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:76985118-76985305 Neighboring gene predicted gene, 36040 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:77000632-77000867 Neighboring gene integrin beta 2 Neighboring gene STARR-seq mESC enhancer starr_27206 Neighboring gene STARR-positive B cell enhancer ABC_E6875 Neighboring gene small ubiquitin-like modifier 3 Neighboring gene STARR-positive B cell enhancer ABC_E3893 Neighboring gene STARR-seq mESC enhancer starr_27207 Neighboring gene ubiquitin-conjugating enzyme E2G 2 Neighboring gene small nuclear ribonucleoprotein G pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (4) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC36923

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
pituitary tumor-transforming gene 1 protein-interacting protein
Names
PTTG-binding factor
pituitary tumor-transforming gene protein-binding factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145925.3NP_666037.1  pituitary tumor-transforming gene 1 protein-interacting protein precursor

    See identical proteins and their annotated locations for NP_666037.1

    Status: VALIDATED

    Source sequence(s)
    AK035696, AW049237, CJ149002
    Consensus CDS
    CCDS23957.1
    UniProtKB/Swiss-Prot
    Q3TVT1, Q8BJ96, Q8N7P0, Q8R143
    UniProtKB/TrEMBL
    Q3U9U7
    Related
    ENSMUSP00000009435.6, ENSMUST00000009435.12

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    77417489..77434566
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011243262.3XP_011241564.1  pituitary tumor-transforming gene 1 protein-interacting protein isoform X1

    See identical proteins and their annotated locations for XP_011241564.1

    UniProtKB/TrEMBL
    F6TFF2
    Related
    ENSMUSP00000124313.3, ENSMUST00000162943.9