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ZFP37 ZFP37 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 7539, updated on 7-Apr-2025

Summary

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Official Symbol
ZFP37provided by HGNC
Official Full Name
ZFP37 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:12863
See related
Ensembl:ENSG00000136866 MIM:602951; AllianceGenome:HGNC:12863
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF906; zfp-37
Summary
This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.7) and 21 other tissues See more
Orthologs
mouse all
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Genomic context

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See ZFP37 in Genome Data Viewer
Location:
9q32
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (113038377..113056724, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (125191240..125228482, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115800657..115819004, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene major urinary protein, pseudogene Neighboring gene zinc finger protein 883 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28832 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:115838681-115839268 Neighboring gene OCT4 hESC enhancer GRCh37_chr9:115846570-115847071 Neighboring gene family with sequence similarity 225 member B Neighboring gene family with sequence similarity 225 member A

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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Related articles in PubMed

  1. Cloning, characterization, and chromosomal assignment of the human ortholog of murine Zfp-37, a candidate gene for Nager syndrome. Dreyer SD, et al. Mamm Genome, 1998 Jun. PMID 9585434
  2. The centromeric/nucleolar chromatin protein ZFP-37 may function to specify neuronal nuclear domains. Payen E, et al. J Biol Chem, 1998 Apr 10. PMID 9535899
  3. AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. Chen Z, et al. Mol Cell Proteomics, 2020 Mar. PMID 31900314, Free PMC Article
  4. HSF1 phosphorylation establishes an active chromatin state via the TRRAP-TIP60 complex and promotes tumorigenesis. Fujimoto M, et al. Nat Commun, 2022 Jul 29. PMID 35906200, Free PMC Article
  5. The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery. Kumar R, et al. Nat Commun, 2017 Nov 27. PMID 29180619, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ38524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding NAS
Non-traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of DNA-templated transcription NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
zinc finger protein 37 homolog
Names
zinc finger protein homologous to Zfp37 in mouse

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047087.2 RefSeqGene

    Range
    5000..23347
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282515.2 → NP_001269444.1  zinc finger protein 37 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI002852, AI005346, AK301275, AL162588, BC126390, DA738387
    Consensus CDS
    CCDS65110.1
    UniProtKB/Swiss-Prot
    Q9Y6Q3
    Related
    ENSP00000452552.1, ENST00000553380.1
    Conserved Domains (6) summary
    smart00349
    Location:47 → 106
    KRAB; krueppel associated box
    COG5048
    Location:288 → 633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450 → 470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:448 → 470
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:47 → 86
    KRAB; KRAB box
    pfam13465
    Location:462 → 486
    zf-H2C2_2; Zinc-finger double domain

  2. NM_001282518.2 → NP_001269447.1  zinc finger protein 37 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AI002852, AI005346, AL162588, BC144145
    Consensus CDS
    CCDS65109.1
    UniProtKB/Swiss-Prot
    Q9Y6Q3
    Related
    ENSP00000451310.1, ENST00000555206.5
    Conserved Domains (6) summary
    cd07765
    Location:33 → 72
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:45 → 92
    KRAB; krueppel associated box
    COG5048
    Location:274 → 619
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436 → 456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434 → 456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:448 → 472
    zf-H2C2_2; Zinc-finger double domain

  3. NM_003408.3 → NP_003399.1  zinc finger protein 37 homolog isoform 3

    See identical proteins and their annotated locations for NP_003399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AI002852, AI005346, AL162588, BC126390
    Consensus CDS
    CCDS6787.1
    UniProtKB/Swiss-Prot
    A0AVJ9, B4DVX4, G3V3L7, Q5T7Q4, Q9Y6Q3
    Related
    ENSP00000363344.3, ENST00000374227.8
    Conserved Domains (6) summary
    cd07765
    Location:33 → 71
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:42 → 91
    KRAB; krueppel associated box
    COG5048
    Location:273 → 618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435 → 455
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:433 → 455
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:447 → 471
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    113038377..113056724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    125191240..125228482 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054363758.1 → XP_054219733.1  zinc finger protein 37 homolog isoform X2

  2. XM_054363757.1 → XP_054219732.1  zinc finger protein 37 homolog isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9Y6Q3.3 GenPept UniProtKB/Swiss-Prot:Q9Y6Q3

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