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ZFP37 ZFP37 zinc finger protein [ Homo sapiens (human) ]

Gene ID: 7539, updated on 1-Jun-2020

Summary

Official Symbol
ZFP37provided by HGNC
Official Full Name
ZFP37 zinc finger proteinprovided by HGNC
Primary source
HGNC:HGNC:12863
See related
Ensembl:ENSG00000136866 MIM:602951
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZNF906; zfp-37
Summary
This gene encodes a transcription factor that belongs to a large family of zinc finger proteins. A similar protein in mouse is thought to play a role in regulating the structures of the nucleolus and centromere in neurons. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Ubiquitous expression in ovary (RPKM 3.5), endometrium (RPKM 2.7) and 21 other tissues See more
Orthologs

Genomic context

See ZFP37 in Genome Data Viewer
Location:
9q32
Exon count:
4
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (113038377..113056724, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (115804144..115819043, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene major urinary protein, pseudogene Neighboring gene zinc finger protein 883 Neighboring gene family with sequence similarity 225 member B Neighboring gene family with sequence similarity 225 member A

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
DNA-binding transcription factor activity NAS
Non-traceable Author Statement
more info
PubMed 
sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
zinc finger protein 37 homolog
Names
zinc finger protein homologous to Zfp37 in mouse

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_047087.1 RefSeqGene

    Range
    5001..19977
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282515.2NP_001269444.1  zinc finger protein 37 homolog isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AI002852, AI005346, AK301275, AL162588, BC126390, DA738387
    Consensus CDS
    CCDS65110.1
    UniProtKB/Swiss-Prot
    Q9Y6Q3
    Related
    ENSP00000452552.1, ENST00000553380.1
    Conserved Domains (6) summary
    smart00349
    Location:47106
    KRAB; krueppel associated box
    COG5048
    Location:288633
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:450470
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:448470
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:4786
    KRAB; KRAB box
    pfam13465
    Location:462486
    zf-H2C2_2; Zinc-finger double domain
  2. NM_001282518.2NP_001269447.1  zinc finger protein 37 homolog isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 2) compared to isoform 1.
    Source sequence(s)
    AI002852, AI005346, AL162588, BC144145
    Consensus CDS
    CCDS65109.1
    UniProtKB/Swiss-Prot
    Q9Y6Q3
    Related
    ENSP00000451310.1, ENST00000555206.5
    Conserved Domains (6) summary
    cd07765
    Location:3372
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:4592
    KRAB; krueppel associated box
    COG5048
    Location:274619
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:436456
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:434456
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:448472
    zf-H2C2_2; Zinc-finger double domain
  3. NM_003408.3NP_003399.1  zinc finger protein 37 homolog isoform 3

    See identical proteins and their annotated locations for NP_003399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
    Source sequence(s)
    AI002852, AI005346, AL162588, BC126390
    Consensus CDS
    CCDS6787.1
    UniProtKB/Swiss-Prot
    Q9Y6Q3
    Related
    ENSP00000363344.3, ENST00000374227.7
    Conserved Domains (6) summary
    cd07765
    Location:3371
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    smart00349
    Location:4291
    KRAB; krueppel associated box
    COG5048
    Location:273618
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:435455
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:433455
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:447471
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    113038377..113056724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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