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YWHAG tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma [ Homo sapiens (human) ]

Gene ID: 7532, updated on 21-Jun-2020

Summary

Official Symbol
YWHAGprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gammaprovided by HGNC
Primary source
HGNC:HGNC:12852
See related
Ensembl:ENSG00000170027 MIM:605356
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EIEE56; PPP1R170; 14-3-3GAMMA
Summary
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the rat ortholog. It is induced by growth factors in human vascular smooth muscle cells, and is also highly expressed in skeletal and heart muscles, suggesting an important role for this protein in muscle tissue. It has been shown to interact with RAF1 and protein kinase C, proteins involved in various signal transduction pathways. [provided by RefSeq, Jul 2008]
Expression
Broad expression in brain (RPKM 260.6), fat (RPKM 131.1) and 22 other tissues See more
Orthologs

Genomic context

See YWHAG in Genome Data Viewer
Location:
7q11.23
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (76326799..76358991, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (75956108..75988342, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr7.2946 Neighboring gene heat shock protein family B (small) member 1 Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene zona pellucida glycoprotein 3 Neighboring gene Sharpr-MPRA regulatory region 7220

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
EPILEPTIC ENCEPHALOPATHY, EARLY INFANTILE, 56
MedGen: C4540034 OMIM: 617665 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide association study of severity in multiple sclerosis.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Expression of HIV-1 Tat downregulates the abundance of tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide (YWHAG, 14-3-3 gamma) in the nucleoli of Jurkat T-cells PubMed
Vpr vpr HIV-1 Vpr inhibits the binding of 14-3-3 gamma and AID to Smu and Sgamma1 DNA regions PubMed
vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with 14-3-3 gamma (YWHAG) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
insulin-like growth factor receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IEA
Inferred from Electronic Annotation
more info
 
protein kinase C binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase C inhibitor activity NAS
Non-traceable Author Statement
more info
PubMed 
receptor tyrosine kinase binding IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
presynapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
14-3-3 protein gamma
Names
KCIP-1
protein kinase C inhibitor protein 1
protein phosphatase 1, regulatory subunit 170
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012479.4NP_036611.2  14-3-3 protein gamma

    See identical proteins and their annotated locations for NP_036611.2

    Status: REVIEWED

    Source sequence(s)
    AB024334, AC006388, BC020963, BI495132
    Consensus CDS
    CCDS5584.1
    UniProtKB/Swiss-Prot
    P61981
    Related
    ENSP00000306330.3, ENST00000307630.5
    Conserved Domains (1) summary
    cd10024
    Location:2247
    14-3-3_gamma; 14-3-3 gamma, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    76326799..76358991 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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