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Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide [ Mus musculus (house mouse) ]

Gene ID: 22628, updated on 1-Mar-2024

Summary

Official Symbol
Ywhagprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptideprovided by MGI
Primary source
MGI:MGI:108109
See related
Ensembl:ENSMUSG00000051391 AllianceGenome:MGI:108109
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
D7Bwg1348e; 14-3-3gamma
Summary
Enables protein domain specific binding activity. Acts upstream of or within protein targeting. Located in myelin sheath. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 56. Orthologous to human YWHAG (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in CNS E18 (RPKM 141.0), frontal lobe adult (RPKM 128.8) and 27 other tissues See more
Orthologs
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Genomic context

See Ywhag in Genome Data Viewer
Location:
5 G2; 5 75.53 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (135937233..135963495, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135908379..135934641, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22450 Neighboring gene heat shock protein 1 Neighboring gene STARR-seq mESC enhancer starr_14600 Neighboring gene predicted gene, 40346 Neighboring gene STARR-seq mESC enhancer starr_14605 Neighboring gene STARR-positive B cell enhancer ABC_E235 Neighboring gene STARR-positive B cell enhancer ABC_E1311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136438585-136438772 Neighboring gene scavenger receptor cysteine rich family, 4 domains Neighboring gene STARR-seq mESC enhancer starr_14608 Neighboring gene zona pellucida glycoprotein 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Gene trapped (1) 
  • Targeted (1)  1 citation
  • Endonuclease-mediated (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables insulin-like growth factor receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein kinase C binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein kinase C binding ISO
Inferred from Sequence Orthology
more info
 
enables protein sequestering activity ISO
Inferred from Sequence Orthology
more info
 
enables receptor tyrosine kinase binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in cellular response to glucose starvation ISO
Inferred from Sequence Orthology
more info
 
involved_in cellular response to insulin stimulus ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of TORC1 signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein targeting IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of synaptic plasticity ISO
Inferred from Sequence Orthology
more info
 
involved_in signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in myelin sheath HDA PubMed 
is_active_in presynapse ISO
Inferred from Sequence Orthology
more info
 
is_active_in synapse ISO
Inferred from Sequence Orthology
more info
 
located_in vesicle ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
14-3-3 protein gamma
Names
14-3-3 gamma
14-3-3 protein gamma subtype
3-monooxgenase/tryptophan 5-monooxgenase activation protein, gamma polypeptide
3-monooxgenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide
3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_018871.3NP_061359.2  14-3-3 protein gamma

    See identical proteins and their annotated locations for NP_061359.2

    Status: VALIDATED

    Source sequence(s)
    AK153307, AK164356, BB419675, BY244024
    Consensus CDS
    CCDS19748.1
    UniProtKB/Swiss-Prot
    P61982, Q3UFD6, Q4FK44
    UniProtKB/TrEMBL
    A8IP69
    Related
    ENSMUSP00000051223.6, ENSMUST00000055808.6
    Conserved Domains (1) summary
    cd10024
    Location:2247
    14-3-3_gamma; 14-3-3 gamma, an isoform of 14-3-3 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    135937233..135963495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)