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YWHAB tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta [ Homo sapiens (human) ]

Gene ID: 7529, updated on 4-Oct-2020

Summary

Official Symbol
YWHABprovided by HGNC
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein betaprovided by HGNC
Primary source
HGNC:HGNC:12849
See related
Ensembl:ENSG00000166913 MIM:601289
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HS1; GW128; YWHAA; KCIP-1; HEL-S-1
Summary
This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in brain (RPKM 158.2), lymph node (RPKM 85.8) and 24 other tissues See more
Orthologs

Genomic context

See YWHAB in Genome Data Viewer
Location:
20q13.12
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (44885705..44908532)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (43514240..43537173)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene potassium two pore domain channel subfamily K member 15 Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene piggyBac transposable element derived 4 pseudogene 2 Neighboring gene poly(A) binding protein cytoplasmic 1 like Neighboring gene translocase of outer mitochondrial membrane 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infection (VSV-G pseudotyped) of CEMT4 T cells downregulates plasma membrane expression of WASF2 PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed
Vpr vpr HIV-1 Vpr inhibits insulin-induced association of 14-3-3 and Foxo3a in HeLa cells PubMed
vpr Interaction of HIV-1 Vpr with human 14-3-3 protein is presumed based on homology to yeast DNA damage checkpoint protein rad25 which enhances HIV-1 Vpr-induced G2 arrest in vitro, most likely through the inhibition of Cdc25 PubMed
integrase gag-pol HIV-1 IN is identified to have a physical interaction with 14-3-3 protein beta/alpha (YWHAB) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cadherin binding HDA PubMed 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone deacetylase binding IPI
Inferred from Physical Interaction
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoprotein binding IPI
Inferred from Physical Interaction
more info
PubMed 
phosphoserine residue binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein C-terminus binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
MAPK cascade TAS
Traceable Author Statement
more info
 
cytoplasmic sequestering of protein IDA
Inferred from Direct Assay
more info
PubMed 
hippo signaling TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
negative regulation of G protein-coupled receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of protein dephosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
positive regulation of catalytic activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
protein targeting IEA
Inferred from Electronic Annotation
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
focal adhesion HDA PubMed 
melanosome IEA
Inferred from Electronic Annotation
more info
 
membrane HDA PubMed 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleus IEA
Inferred from Electronic Annotation
more info
 
perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional repressor complex IEA
Inferred from Electronic Annotation
more info
 
vacuolar membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
14-3-3 protein beta/alpha
Names
14-3-3 alpha
epididymis secretory protein Li 1
protein 1054
protein kinase C inhibitor protein-1
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003404.5NP_003395.1  14-3-3 protein beta/alpha

    See identical proteins and their annotated locations for NP_003395.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AA845374, AK292717, AL008725, DB443535
    Consensus CDS
    CCDS13339.1
    UniProtKB/Swiss-Prot
    P31946
    UniProtKB/TrEMBL
    V9HWD6
    Related
    ENSP00000361930.3, ENST00000372839.7
    Conserved Domains (1) summary
    cd10022
    Location:4232
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
  2. NM_139323.4NP_647539.1  14-3-3 protein beta/alpha

    See identical proteins and their annotated locations for NP_647539.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
    Source sequence(s)
    AA845374, AL008725, BC001359, DB443535
    Consensus CDS
    CCDS13339.1
    UniProtKB/Swiss-Prot
    P31946
    UniProtKB/TrEMBL
    V9HWD6
    Related
    ENSP00000300161.4, ENST00000353703.9
    Conserved Domains (1) summary
    cd10022
    Location:4232
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    44885705..44908532
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017028040.1XP_016883529.1  14-3-3 protein beta/alpha isoform X2

    Related
    ENSP00000394729.1, ENST00000428262.1
    Conserved Domains (1) summary
    cl02098
    Location:4100
    14-3-3; 14-3-3 domain
  2. XM_017028039.2XP_016883528.1  14-3-3 protein beta/alpha isoform X1

    UniProtKB/Swiss-Prot
    P31946
    UniProtKB/TrEMBL
    V9HWD6
    Conserved Domains (1) summary
    cd10022
    Location:4232
    14-3-3_beta_zeta; 14-3-3 beta and zeta isoforms of 14-3-3 protein
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