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Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide [ Mus musculus (house mouse) ]

Gene ID: 54401, updated on 30-Apr-2024

Summary

Official Symbol
Ywhabprovided by MGI
Official Full Name
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptideprovided by MGI
Primary source
MGI:MGI:1891917
See related
Ensembl:ENSMUSG00000018326 AllianceGenome:MGI:1891917
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
14-3-3b; 1300003C17Rik
Summary
Enables protein domain specific binding activity. Acts upstream of or within protein targeting. Predicted to be located in cytosol; nucleus; and perinuclear region of cytoplasm. Predicted to be part of transcription repressor complex. Predicted to be active in cytoplasm. Is expressed in several structures, including genitourinary system; nervous system; palatal shelf; retina layer; and thymus. Orthologous to human YWHAB (tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in cortex adult (RPKM 73.1), CNS E18 (RPKM 72.1) and 28 other tissues See more
Orthologs
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Genomic context

See Ywhab in Genome Data Viewer
Location:
2 H3; 2 84.59 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (163837082..163860508)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (163995197..164018588)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene regulating synaptic membrane exocytosis 4 Neighboring gene predicted gene, 35886 Neighboring gene STARR-positive B cell enhancer ABC_E3417 Neighboring gene poly(A) binding protein, cytoplasmic 1-like Neighboring gene STARR-positive B cell enhancer ABC_E10160 Neighboring gene translocase of outer mitochondrial membrane 34

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Targeted (2) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
 
enables histone deacetylase binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoprotein binding ISO
Inferred from Sequence Orthology
more info
 
enables phosphoserine residue binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase inhibitor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in perinuclear region of cytoplasm ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of transcription repressor complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
14-3-3 protein beta/alpha
Names
14-3-3 protein beta
KCIP-1
protein kinase C inhibitor protein 1
tyrosine 3/tryptophan 5 -monooxygenase activation protein, beta polypeptide

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001418430.1NP_001405359.1  14-3-3 protein beta/alpha

    Status: VALIDATED

    Source sequence(s)
    AL591542
    UniProtKB/Swiss-Prot
    O70455, Q3TY33, Q3UAN6, Q9CQV8
    UniProtKB/TrEMBL
    A2A5N2
  2. NM_001418433.1NP_001405362.1  14-3-3 protein beta/alpha

    Status: VALIDATED

    Source sequence(s)
    AL591542
    UniProtKB/Swiss-Prot
    O70455, Q3TY33, Q3UAN6, Q9CQV8
    UniProtKB/TrEMBL
    A2A5N2
  3. NM_001418434.1NP_001405363.1  14-3-3 protein beta/alpha

    Status: VALIDATED

    Source sequence(s)
    AL591542
    UniProtKB/Swiss-Prot
    O70455, Q3TY33, Q3UAN6, Q9CQV8
    UniProtKB/TrEMBL
    A2A5N2
  4. NM_018753.7NP_061223.2  14-3-3 protein beta/alpha

    See identical proteins and their annotated locations for NP_061223.2

    Status: VALIDATED

    Source sequence(s)
    AL591542
    Consensus CDS
    CCDS17019.1
    UniProtKB/Swiss-Prot
    O70455, Q3TY33, Q3UAN6, Q9CQV8
    UniProtKB/TrEMBL
    A2A5N2
    Related
    ENSMUSP00000018470.4, ENSMUST00000018470.10
    Conserved Domains (1) summary
    cl02098
    Location:4232
    14-3-3; 14-3-3 domain

RNA

  1. NR_184744.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591542

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    163837082..163860508
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006499909.3XP_006499972.1  14-3-3 protein beta/alpha isoform X1

    See identical proteins and their annotated locations for XP_006499972.1

    UniProtKB/Swiss-Prot
    O70455, Q3TY33, Q3UAN6, Q9CQV8
    UniProtKB/TrEMBL
    A2A5N2
    Conserved Domains (1) summary
    cl02098
    Location:4232
    14-3-3; 14-3-3 domain