WNT5A Wnt family member 5A [ Homo sapiens (human) ]

Gene ID: 7474, updated on 25-Dec-2022

Summary

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Official Symbol: WNT5Aprovided by HGNC
Official Full Name: Wnt family member 5Aprovided by HGNC
Primary source: HGNC:HGNC:12784
See related: Ensembl:ENSG00000114251 MIM:164975; AllianceGenome:HGNC:12784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hWNT5A
Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression: Broad expression in urinary bladder (RPKM 9.1), endometrium (RPKM 7.3) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

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See WNT5A in Genome Data Viewer

Location:: 3p14.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (55465715..55505263, complement)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (55499921..55521497, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (55499743..55521334, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNT5A, betacatenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction.
Title: WNT5A, β‑catenin and SUFU expression patterns, and the significance of microRNA deregulation in placentas with intrauterine growth restriction.
Interferon-dependent SLC14A1[+] cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer.
Title: Interferon-dependent SLC14A1+ cancer-associated fibroblasts promote cancer stemness via WNT5A in bladder cancer.
[Wnt5a activates JNK to promote the proliferation and autophagy of KGN human granulosa cells].
Title: [Wnt5a activates JNK to promote the proliferation and autophagy of KGN human granulosa cells].
Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene.
Title: Memory B-cell like chronic lymphocytic leukaemia is associated with specific methylation profile of WNT5A promoter and undetectable expression of WNT5A gene.
Wnt2b and Wnt5a expression is highly associated with M2 TAMs in nonsmall cell lung cancer.
Title: Wnt2b and Wnt5a expression is highly associated with M2 TAMs in non‑small cell lung cancer.
Tumor suppressive functions of WNT5A in rhabdomyosarcoma.
Title: Tumor suppressive functions of WNT5A in rhabdomyosarcoma.
WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Title: WNT5A promotes the metastasis of esophageal squamous cell carcinoma by activating the HDAC7/SNAIL signaling pathway.
Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus.
Title: Correlation of plasma and urine Wnt5A with the disease activity and cutaneous lesion severity in patients with systemic lupus erythematosus.
Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a.
Title: Knockdown of lncRNA ACTA2-AS1 reverses cisplatin resistance of ovarian cancer cells via inhibition of miR-378a-3p-regulated Wnt5a.
GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.
Title: GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation.

Submit: New GeneRIF Correction See all GeneRIFs (406)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autosomal dominant Robinow syndrome 1 MedGen: C4551475 OMIM: 180700 GeneReviews: Autosomal Dominant Robinow Syndrome	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of WNT5a in human neural stem cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78427 (e-PCR)
- UniSTS:51220

SHGC-77018 (e-PCR)
- UniSTS:65072

RH102004 (e-PCR)
- UniSTS:96338

G35315 (e-PCR)
- UniSTS:2149

NoName (e-PCR)
- UniSTS:481910

Wnt5a (e-PCR), detects polymorphism
- UniSTS:277885

RH80790 (e-PCR)
- UniSTS:92060

G15856 (e-PCR)
- UniSTS:3037

NoName (e-PCR)
- UniSTS:480766

Homology

Homologs of the WNT5A gene: The WNT5A gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 429 organisms have orthologs with human gene WNT5A
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemoattractant activity involved in axon guidance	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	TAS Traceable Author Statement more info	PubMed
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IC Inferred by Curator more info	PubMed
enables receptor tyrosine kinase-like orphan receptor binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation	NAS Non-traceable Author Statement more info	PubMed
involved_in Wnt signaling pathway, calcium modulating pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, calcium modulating pathway	NAS Non-traceable Author Statement more info	PubMed
involved_in Wnt signaling pathway, planar cell polarity pathway	TAS Traceable Author Statement more info	PubMed
involved_in activation of GTPase activity	IEA Inferred from Electronic Annotation more info
acts_upstream_of activation of protein kinase B activity	IDA Inferred from Direct Assay more info	PubMed
involved_in anterior/posterior axis specification, embryo	IEA Inferred from Electronic Annotation more info
involved_in atrial septum development	IEA Inferred from Electronic Annotation more info
involved_in axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in cellular response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
involved_in cervix development	IEA Inferred from Electronic Annotation more info
involved_in chemoattraction of serotonergic neuron axon	IEA Inferred from Electronic Annotation more info
involved_in chemorepulsion of dopaminergic neuron axon	IEA Inferred from Electronic Annotation more info
involved_in cochlea morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in convergent extension involved in axis elongation	IEA Inferred from Electronic Annotation more info
involved_in convergent extension involved in organogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in epithelial cell migration	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation involved in mammary gland duct elongation	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	IEP Inferred from Expression Pattern more info	PubMed
involved_in establishment of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
involved_in establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in excitatory synapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in face development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart looping	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in hindgut morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in hypophysis morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in inhibitory synapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in keratinocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
involved_in kidney development	IEA Inferred from Electronic Annotation more info
involved_in lateral sprouting involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in lens development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in lung development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
involved_in mammary gland branching involved in thelarche	IEA Inferred from Electronic Annotation more info
involved_in meiotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in melanocyte proliferation	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in mesenchymal-epithelial cell signaling	IEA Inferred from Electronic Annotation more info
involved_in mesodermal to mesenchymal transition involved in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in midgut development	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell proliferation in midbrain	NAS Non-traceable Author Statement more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mesenchymal cell proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of prostatic bud formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in non-canonical Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
involved_in non-canonical Wnt signaling pathway via JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in notochord morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb interneuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic cup formation involved in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in paraxial mesoderm formation	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in axis elongation	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in cardiac muscle tissue morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in cardiac right atrium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in gastrula mediolateral intercalation	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in midbrain dopaminergic neuron differentiation	TAS Traceable Author Statement more info	PubMed
involved_in planar cell polarity pathway involved in neural tube closure	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in outflow tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in pericardium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in planar cell polarity pathway involved in ventricular septum morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of JUN kinase activity	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of positive regulation of JUN kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cartilage development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron death	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection arborization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of peptidyl-serine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of peptidyl-threonine phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein binding	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein kinase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein kinase C signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to synapse	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of timing of anagen	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
involved_in post-anal tail morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in postsynapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in primary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in primitive streak formation	IEA Inferred from Electronic Annotation more info
involved_in protein localization	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in regulation of I-kappaB kinase/NF-kappaB signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to organic substance	IEP Inferred from Expression Pattern more info	PubMed
involved_in secondary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in secondary palate development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in somitogenesis	IEA Inferred from Electronic Annotation more info
involved_in thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in type B pancreatic cell development	IEA Inferred from Electronic Annotation more info
involved_in urinary bladder development	IEA Inferred from Electronic Annotation more info
involved_in uterus development	IEA Inferred from Electronic Annotation more info
involved_in vagina development	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
located_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated endocytic vesicle membrane	TAS Traceable Author Statement more info
colocalizes_with collagen-containing extracellular matrix	HDA more info	PubMed
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	TAS Traceable Author Statement more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein Wnt-5a

Names: WNT-5A protein; epididymis secretory sperm binding protein; wingless-type MMTV integration site family, member 5A

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031992.2 RefSeqGene

Range

22957..44548

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001256105.1 → NP_001243034.1 protein Wnt-5a isoform 2 precursor

See identical proteins and their annotated locations for NP_001243034.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.

Source sequence(s)

AC121764, AK290869, BU742635, DB224740

Consensus CDS

CCDS58835.1

UniProtKB/Swiss-Prot

P41221

UniProtKB/TrEMBL

A0A024R316

Related

ENSP00000420104.1, ENST00000497027.5

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
NM_001377271.1 → NP_001364200.1 protein Wnt-5a isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC121764

Consensus CDS

CCDS58835.1

UniProtKB/TrEMBL

A0A024R316

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
NM_001377272.1 → NP_001364201.1 protein Wnt-5a isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC121764

Consensus CDS

CCDS58835.1

UniProtKB/TrEMBL

A0A024R316

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
NM_003392.7 → NP_003383.4 protein Wnt-5a isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC121764, AK090582, BC064694, BU742635

Consensus CDS

CCDS46850.1

UniProtKB/Swiss-Prot

Q6P278

UniProtKB/TrEMBL

A0A384N611

Related

ENSP00000264634.4, ENST00000264634.9

Conserved Domains (1) summary

cd19347
Location:69 → 380

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

55465715..55505263 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448855.1 → XP_047304811.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448853.1 → XP_047304809.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448857.1 → XP_047304813.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448854.1 → XP_047304810.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448859.1 → XP_047304815.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_011534086.3 → XP_011532388.1 protein Wnt-5a isoform X1

See identical proteins and their annotated locations for XP_011532388.1

UniProtKB/Swiss-Prot

P41221

UniProtKB/TrEMBL

A0A024R316

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_017007128.2 → XP_016862617.1 protein Wnt-5a isoform X1

UniProtKB/Swiss-Prot

P41221

UniProtKB/TrEMBL

A0A024R316

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_047448858.1 → XP_047304814.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448862.1 → XP_047304818.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448861.1 → XP_047304817.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448856.1 → XP_047304812.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448860.1 → XP_047304816.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_047448852.1 → XP_047304808.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

A0A024R316
XM_017007127.2 → XP_016862616.1 protein Wnt-5a isoform X2
XM_011534088.3 → XP_011532390.1 protein Wnt-5a isoform X1

See identical proteins and their annotated locations for XP_011532390.1

UniProtKB/Swiss-Prot

P41221

UniProtKB/TrEMBL

A0A024R316

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_011534089.2 → XP_011532391.1 protein Wnt-5a isoform X1

See identical proteins and their annotated locations for XP_011532391.1

UniProtKB/Swiss-Prot

P41221

UniProtKB/TrEMBL

A0A024R316

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins