WNT5A Wnt family member 5A [ Homo sapiens (human) ]

Gene ID: 7474, updated on 6-Jan-2026

Summary

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Official Symbol: WNT5Aprovided by HGNC
Official Full Name: Wnt family member 5Aprovided by HGNC
Primary source: HGNC:HGNC:12784
See related: Ensembl:ENSG00000114251 MIM:164975; AllianceGenome:HGNC:12784
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: hWNT5A
Summary: The WNT gene family consists of structurally related genes which encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene encodes a member of the WNT family that signals through both the canonical and non-canonical WNT pathways. This protein is a ligand for the seven transmembrane receptor frizzled-5 and the tyrosine kinase orphan receptor 2. This protein plays an essential role in regulating developmental pathways during embryogenesis. This protein may also play a role in oncogenesis. Mutations in this gene are the cause of autosomal dominant Robinow syndrome. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012]
Expression: Broad expression in urinary bladder (RPKM 9.1), endometrium (RPKM 7.3) and 19 other tissues See more
Orthologs: mouse all
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Genomic context

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See WNT5A in Genome Data Viewer

Location:: 3p14.3

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	3	NC_000003.12 (55465715..55505263, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	3	NC_060927.1 (55499921..55539460, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	3	NC_000003.11 (55499743..55521334, complement)

Chromosome 3 - NC_000003.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

WNT5A is a putative epi-driver of prostate cancer metastasis to the bone.
Title: WNT5A is a putative epi-driver of prostate cancer metastasis to the bone.
Differential expression of WNT5A long and short isoforms in non-muscle-invasive bladder urothelial carcinoma.
Title: Differential expression of WNT5A long and short isoforms in non-muscle-invasive bladder urothelial carcinoma.
Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma.
Title: Wnt5a-mediated autophagy contributes to the epithelial-mesenchymal transition of human bronchial epithelial cells during asthma.
Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1 downregulation and Wnt5a/NF-kappaB activation.
Title: Upregulated miR-374a-5p drives psoriasis pathogenesis through WIF1 downregulation and Wnt5a/NF-κB activation.
WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the beta-catenin signaling pathway.
Title: WNT5A regulates the proliferation, apoptosis and stemness of human stem Leydig cells via the β-catenin signaling pathway.
Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil.
Title: Exploring the role of the WNT5A rs566926 polymorphism and its interactions in non-syndromic orofacial cleft: a multicenter study in Brazil.
Associations of Wnt5a expression with liver injury in chronic hepatitis B virus infection.
Title: Associations of Wnt5a expression with liver injury in chronic hepatitis B virus infection.
WNT5A: a double-edged sword in colorectal cancer progression.
Title: WNT5A: a double-edged sword in colorectal cancer progression.
Expression of Wnt5a and ROR2, Components of the Noncanonical Wnt-Signaling Pathway, is Associated with Tumor Differentiation in Hepatocellular Carcinoma.
Title: Expression of Wnt5a and ROR2, Components of the Noncanonical Wnt-Signaling Pathway, is Associated with Tumor Differentiation in Hepatocellular Carcinoma.
FOXE1 Contributes to the Development of Psoriasis by Regulating WNT5A.
Title: FOXE1 Contributes to the Development of Psoriasis by Regulating WNT5A.

Submit: New GeneRIF Correction See all GeneRIFs (427)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autosomal dominant Robinow syndrome 1 MedGen: C4551475 OMIM: 180700 GeneReviews: Autosomal Dominant Robinow Syndrome	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	HIV-1 gp120 upregulates the expression of WNT5a in human neural stem cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78427 (e-PCR)
- UniSTS:51220

SHGC-77018 (e-PCR)
- UniSTS:65072

RH102004 (e-PCR)
- UniSTS:96338

G35315 (e-PCR)
- UniSTS:2149

NoName (e-PCR)
- UniSTS:481910

Wnt5a (e-PCR), detects polymorphism
- UniSTS:277885

RH80790 (e-PCR)
- UniSTS:92060

G15856 (e-PCR)
- UniSTS:3037

NoName (e-PCR)
- UniSTS:480766

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables chemoattractant activity involved in axon guidance	IEA Inferred from Electronic Annotation more info
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables frizzled binding	IBA Inferred from Biological aspect of Ancestor more info
enables frizzled binding	IEA Inferred from Electronic Annotation more info
enables frizzled binding	IPI Inferred from Physical Interaction more info	PubMed
enables frizzled binding	TAS Traceable Author Statement more info	PubMed
enables phospholipid binding	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IEA Inferred from Electronic Annotation more info
enables receptor ligand activity	IC Inferred by Curator more info	PubMed
enables receptor tyrosine kinase-like orphan receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, calcium modulating pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, calcium modulating pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in Wnt signaling pathway, calcium modulating pathway	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway	IEA Inferred from Electronic Annotation more info
involved_in Wnt signaling pathway, planar cell polarity pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in Wnt signaling pathway, planar cell polarity pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within ameboidal-type cell migration	IEA Inferred from Electronic Annotation more info
involved_in anterior/posterior axis specification, embryo	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within anterior/posterior pattern specification	IEA Inferred from Electronic Annotation more info
involved_in atrial septum development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within axis elongation	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in axon guidance	ISS Inferred from Sequence or Structural Similarity more info
involved_in axonogenesis	IEA Inferred from Electronic Annotation more info
involved_in canonical Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in cartilage development	IEA Inferred from Electronic Annotation more info
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in cell fate commitment	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell migration	IEA Inferred from Electronic Annotation more info
involved_in cellular response to calcium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to lipopolysaccharide	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to molecule of bacterial origin	IEA Inferred from Electronic Annotation more info
involved_in cellular response to retinoic acid	ISS Inferred from Sequence or Structural Similarity more info
involved_in cellular response to transforming growth factor beta stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to type II interferon	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within cervix development	IEA Inferred from Electronic Annotation more info
involved_in chemoattraction of serotonergic neuron axon	IEA Inferred from Electronic Annotation more info
involved_in chemoattraction of serotonergic neuron axon	ISS Inferred from Sequence or Structural Similarity more info
involved_in chemorepulsion of dopaminergic neuron axon	IEA Inferred from Electronic Annotation more info
involved_in chemorepulsion of dopaminergic neuron axon	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cochlea morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in axis elongation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within convergent extension involved in organogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within determination of left/right symmetry	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within development of primary male sexual characteristics	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within digestive tract morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic digit morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryonic limb morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in embryonic skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation	IEA Inferred from Electronic Annotation more info
involved_in epithelial to mesenchymal transition	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within establishment of planar polarity	IEA Inferred from Electronic Annotation more info
involved_in excitatory synapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in face development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in genitalia development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within heart looping	IEA Inferred from Electronic Annotation more info
involved_in hematopoietic stem cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hindgut morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within hypophysis morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inhibitory synapse assembly	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within inner ear morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in intracellular protein localization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within intracellular protein localization	IEA Inferred from Electronic Annotation more info
involved_in keratinocyte differentiation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lateral sprouting involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in lens development in camera-type eye	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within limb morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within lung development	IEA Inferred from Electronic Annotation more info
involved_in macrophage derived foam cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within male gonad development	IEA Inferred from Electronic Annotation more info
involved_in male gonad development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within mammary gland branching involved in thelarche	IEA Inferred from Electronic Annotation more info
involved_in melanocyte proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesenchymal-epithelial cell signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mesodermal to mesenchymal transition involved in gastrulation	IEA Inferred from Electronic Annotation more info
involved_in midbrain development	IEA Inferred from Electronic Annotation more info
involved_in midbrain dopaminergic neuron differentiation	IEA Inferred from Electronic Annotation more info
involved_in midbrain dopaminergic neuron differentiation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within midgut development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within morphogenesis of an epithelium	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative chemotaxis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of BMP signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of apoptotic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of cell proliferation in midbrain	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of cell proliferation in midbrain	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fat cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of melanin biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of mesenchymal cell proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of prostatic bud formation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of synapse assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within neural tube development	IEA Inferred from Electronic Annotation more info
involved_in neurogenesis	IEA Inferred from Electronic Annotation more info
involved_in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuron differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in non-canonical Wnt signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within notochord morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb interneuron development	IEA Inferred from Electronic Annotation more info
involved_in olfactory bulb interneuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in optic cup formation involved in camera-type eye development	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within paraxial mesoderm formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pericardium morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of JNK cascade	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of JNK cascade	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of MAPK cascade	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of Rac protein signal transduction	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell chemotaxis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of cartilage development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by cadherin	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of chemokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of cytokine production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of endocytosis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of endothelial cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of fibroblast proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of inflammatory response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of interleukin-6 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-6 production	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of macrophage activation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of macrophage cytokine production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of meiotic nuclear division	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection arborization	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection arborization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of neuron projection development	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of neuron projection development	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of ossification	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of protein catabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of protein kinase C activity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to synapse	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of small GTPase mediated signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of thymocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of timing of anagen	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of type I interferon-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of type II interferon production	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within post-anal tail morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in postsynapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in postsynaptic modulation of chemical synaptic transmission	IEA Inferred from Electronic Annotation more info
involved_in presynapse assembly	TAS Traceable Author Statement more info	PubMed
involved_in primary heart field specification	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within primitive streak formation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	IEA Inferred from Electronic Annotation more info
involved_in regulation of canonical NF-kappaB signal transduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of inflammatory response	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of postsynapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of postsynaptic cytosolic calcium ion concentration	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of protein localization	IEA Inferred from Electronic Annotation more info
involved_in regulation of synapse organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of synapse organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in secondary heart field specification	IEA Inferred from Electronic Annotation more info
involved_in secondary palate development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somite development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somitogenesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within tube closure	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within type B pancreatic cell development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within urinary bladder development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within uterus development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vagina development	IEA Inferred from Electronic Annotation more info
involved_in ventricular septum development	IEA Inferred from Electronic Annotation more info
involved_in wound healing	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi lumen	TAS Traceable Author Statement more info
is_active_in Schaffer collateral - CA1 synapse	IEA Inferred from Electronic Annotation more info
located_in cell surface	IEA Inferred from Electronic Annotation more info
located_in clathrin-coated endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endocytic vesicle membrane	TAS Traceable Author Statement more info
located_in endoplasmic reticulum lumen	TAS Traceable Author Statement more info
located_in extracellular exosome	TAS Traceable Author Statement more info
colocalizes_with extracellular matrix	HDA more info	PubMed
located_in extracellular matrix	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular region	TAS Traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IEA Inferred from Electronic Annotation more info
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in plasma membrane	TAS Traceable Author Statement more info
located_in postsynapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: protein Wnt-5a

Names: WNT-5A protein; epididymis secretory sperm binding protein; wingless-type MMTV integration site family, member 5A

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_031992.2 RefSeqGene

Range

22957..44548

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001256105.1 → NP_001243034.1 protein Wnt-5a isoform 2 precursor

See identical proteins and their annotated locations for NP_001243034.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1.

Source sequence(s)

AC121764, AK290869, BU742635, DB224740

Consensus CDS

CCDS58835.1

UniProtKB/TrEMBL

Q6DK41

Related

ENSP00000420104.1, ENST00000497027.5

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
NM_001377271.1 → NP_001364200.1 protein Wnt-5a isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC121764

Consensus CDS

CCDS58835.1

UniProtKB/TrEMBL

Q6DK41

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
NM_001377272.1 → NP_001364201.1 protein Wnt-5a isoform 2 precursor

Status: REVIEWED

Source sequence(s)

AC121764

Consensus CDS

CCDS58835.1

UniProtKB/TrEMBL

Q6DK41

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
NM_003392.7 → NP_003383.4 protein Wnt-5a isoform 1 precursor

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes isoform 1.

Source sequence(s)

AC121764, AK090582, BC064694, BU742635

Consensus CDS

CCDS46850.1

UniProtKB/Swiss-Prot

A8K4A4, P41221, Q6P278

UniProtKB/TrEMBL

A0A384N611, Q6DK41

Related

ENSP00000264634.4, ENST00000264634.9

Conserved Domains (1) summary

cd19347
Location:69 → 380

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000003.12 Reference GRCh38.p14 Primary Assembly

Range

55465715..55505263 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047448855.1 → XP_047304811.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448853.1 → XP_047304809.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448857.1 → XP_047304813.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448854.1 → XP_047304810.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448859.1 → XP_047304815.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_011534086.3 → XP_011532388.1 protein Wnt-5a isoform X1

See identical proteins and their annotated locations for XP_011532388.1

UniProtKB/TrEMBL

Q6DK41

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_017007128.2 → XP_016862617.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_047448858.1 → XP_047304814.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448862.1 → XP_047304818.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448861.1 → XP_047304817.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448856.1 → XP_047304812.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448860.1 → XP_047304816.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_047448852.1 → XP_047304808.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_017007127.2 → XP_016862616.1 protein Wnt-5a isoform X2

UniProtKB/TrEMBL

Q6DK41
XM_011534088.3 → XP_011532390.1 protein Wnt-5a isoform X1

See identical proteins and their annotated locations for XP_011532390.1

UniProtKB/TrEMBL

Q6DK41

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
XM_011534089.2 → XP_011532391.1 protein Wnt-5a isoform X1

See identical proteins and their annotated locations for XP_011532391.1

UniProtKB/TrEMBL

Q6DK41

Conserved Domains (1) summary

cd19347
Location:54 → 365

Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

Alternate T2T-CHM13v2.0

Genomic

NC_060927.1 Alternate T2T-CHM13v2.0

Range

55499921..55539460 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054347752.1 → XP_054203727.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_054347756.1 → XP_054203731.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_054347755.1 → XP_054203730.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_054347753.1 → XP_054203728.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_054347754.1 → XP_054203729.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_054347750.1 → XP_054203725.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_054347751.1 → XP_054203726.1 protein Wnt-5a isoform X2

UniProtKB/TrEMBL

Q6DK41
XM_054347757.1 → XP_054203732.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41
XM_054347758.1 → XP_054203733.1 protein Wnt-5a isoform X1

UniProtKB/TrEMBL

Q6DK41