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Wnt5a wingless-type MMTV integration site family, member 5A [ Mus musculus (house mouse) ]

Gene ID: 22418, updated on 7-Jun-2022

Summary

Official Symbol
Wnt5aprovided by MGI
Official Full Name
wingless-type MMTV integration site family, member 5Aprovided by MGI
Primary source
MGI:MGI:98958
See related
Ensembl:ENSMUSG00000021994 AllianceGenome:MGI:98958
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Wnt-5a; 8030457G12Rik
Summary
Enables frizzled binding activity; protein domain specific binding activity; and receptor ligand activity. Involved in several processes, including Wnt signaling pathway; heart development; and positive regulation of macromolecule metabolic process. Acts upstream of or within several processes, including animal organ development; positive regulation of protein phosphorylation; and regulation of animal organ morphogenesis. Located in cell surface and extracellular matrix. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; limb; and sensory organ. Used to study Robinow syndrome. Human ortholog(s) of this gene implicated in autosomal dominant Robinow syndrome 1. Orthologous to human WNT5A (Wnt family member 5A). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 24.5), bladder adult (RPKM 18.8) and 17 other tissues See more
Orthologs
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Genomic context

See Wnt5a in Genome Data Viewer
Location:
14 A3; 14 16.8 cM
Exon count:
10
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (28224962..28249405)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (28504543..28527448)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 14 NC_000080.5 (29318659..29338620)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene ELKS/RAB6-interacting/CAST family member 2 Neighboring gene predicted gene, 53838 Neighboring gene predicted gene, 52097 Neighboring gene predicted gene, 35164 Neighboring gene ribosomal protein L5 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (4)  1 citation
  • Chemically induced (ENU) (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables chemoattractant activity involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
enables cytokine activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cytokine activity IDA
Inferred from Direct Assay
more info
PubMed 
enables frizzled binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables frizzled binding IDA
Inferred from Direct Assay
more info
PubMed 
enables frizzled binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables frizzled binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables receptor tyrosine kinase-like orphan receptor binding ISO
Inferred from Sequence Orthology
more info
 
enables signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables signaling receptor binding TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within JNK cascade IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in Wnt signaling pathway involved in midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in Wnt signaling pathway, calcium modulating pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway, calcium modulating pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in Wnt signaling pathway, calcium modulating pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within Wnt signaling pathway, planar cell polarity pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of activation of protein kinase B activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within animal organ morphogenesis TAS
Traceable Author Statement
more info
PubMed 
involved_in anterior/posterior axis specification, embryo IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within anterior/posterior pattern specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in atrial septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in axonal fasciculation TAS
Traceable Author Statement
more info
PubMed 
involved_in axonogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cartilage development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in cell fate commitment IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within cell migration IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within cell-cell signaling TAS
Traceable Author Statement
more info
PubMed 
involved_in cellular response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cervix development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in chemoattraction of serotonergic neuron axon IDA
Inferred from Direct Assay
more info
PubMed 
involved_in chemorepulsion of dopaminergic neuron axon IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within cochlea morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cochlea morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within convergent extension IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within convergent extension involved in organogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within determination of left/right symmetry IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within development of primary male sexual characteristics IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryo development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic digit morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within embryonic limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in embryonic skeletal system development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within epithelial cell proliferation involved in mammary gland duct elongation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within establishment of epithelial cell apical/basal polarity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within establishment of planar polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in face development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in genitalia development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within heart looping IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in hematopoietic stem cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within hindgut morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hypophysis morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within inner ear morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within kidney development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lateral sprouting involved in mammary gland duct morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within limb morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within lung development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within male gonad development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mammary gland branching involved in thelarche IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in melanocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesenchymal-epithelial cell signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within mesodermal to mesenchymal transition involved in gastrulation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in midbrain development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in midbrain development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in midbrain dopaminergic neuron differentiation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in midbrain dopaminergic neuron differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in midbrain dopaminergic neuron differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midgut development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within morphogenesis of an epithelium IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within negative chemotaxis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of BMP signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of axon extension involved in axon guidance IGI
Inferred from Genetic Interaction
more info
PubMed 
NOT involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of canonical Wnt signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell proliferation in midbrain IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fat cell differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of fibroblast growth factor receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of melanin biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of mesenchymal cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of prostatic bud formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of synapse assembly IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neural tube closure IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within neural tube development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in neurogenesis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in neuron projection morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in non-canonical Wnt signaling pathway via JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within notochord morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in olfactory bulb interneuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within paraxial mesoderm formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within pericardium morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in axis elongation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in axis elongation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in planar cell polarity pathway involved in axon guidance IDA
Inferred from Direct Assay
more info
PubMed 
involved_in planar cell polarity pathway involved in axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in cardiac muscle tissue morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in cardiac right atrium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in gastrula mediolateral intercalation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in neural tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in outflow tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in pericardium morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within planar cell polarity pathway involved in ventricular septum morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of positive regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of JUN kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of positive regulation of JUN kinase activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of T cell chemotaxis ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cartilage development IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of cartilage development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cell-cell adhesion ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cell-cell adhesion mediated by cadherin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of chemokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of cytokine production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of cytokine production involved in immune response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of endocytosis IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of endothelial cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of endothelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of epithelial cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of fibroblast proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of hematopoietic stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of inflammatory response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-gamma production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of interleukin-6 production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interleukin-8 production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage activation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage cytokine production ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of meiotic nuclear division IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of mesenchymal cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neuron death IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of neuron projection arborization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of neuron projection arborization ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of neuron projection development IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of non-canonical Wnt signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of ossification ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of peptidyl-threonine phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase C activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase C signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of response to cytokine stimulus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of timing of anagen IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription, DNA-templated ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of tumor necrosis factor production IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-anal tail morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within post-anal tail morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in primary heart field specification IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within primitive streak formation IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein phosphorylation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of I-kappaB kinase/NF-kappaB signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within regulation of branching involved in mammary gland duct morphogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of postsynapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of postsynaptic cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of protein localization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of synapse organization ISO
Inferred from Sequence Orthology
more info
 
involved_in secondary heart field specification IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in secondary palate development ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within signal transduction TAS
Traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within somite development IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within somitogenesis IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of stem cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of thymocyte apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within tube closure IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within type B pancreatic cell development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within urinary bladder development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within uterus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within vagina development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in ventricular septum development IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in wound healing ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
located_in extracellular matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
 
located_in extracellular region TAS
Traceable Author Statement
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular space ISO
Inferred from Sequence Orthology
more info
 
is_active_in glutamatergic synapse ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
protein Wnt-5a
Names
wingless-related MMTV integration site 5A

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256224.2NP_001243153.1  protein Wnt-5a isoform 2 precursor

    See identical proteins and their annotated locations for NP_001243153.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. These differences result in a distinct 5' UTR and cause translation initiation at a downstream start codon, compared to variant 1. The encoded protein (isoform 2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK036824, CT025649
    Consensus CDS
    CCDS56946.1
    UniProtKB/Swiss-Prot
    P22725
    Related
    ENSMUSP00000107891.2, ENSMUST00000112272.2
    Conserved Domains (1) summary
    cd19347
    Location:49360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
  2. NM_009524.4NP_033550.2  protein Wnt-5a isoform 1 precursor

    See identical proteins and their annotated locations for NP_033550.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK031512, AK031597, AK036824, BY721304, CT025649
    Consensus CDS
    CCDS26888.1
    UniProtKB/Swiss-Prot
    P22725
    Related
    ENSMUSP00000064878.5, ENSMUST00000063465.12
    Conserved Domains (1) summary
    cd19347
    Location:69380
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    28224962..28249405
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030247779.2XP_030103639.1  protein Wnt-5a isoform X2

    Conserved Domains (1) summary
    cd19347
    Location:49360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
  2. XM_006518924.4XP_006518987.1  protein Wnt-5a isoform X2

    See identical proteins and their annotated locations for XP_006518987.1

    UniProtKB/Swiss-Prot
    P22725
    Conserved Domains (1) summary
    cd19347
    Location:49360
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins
  3. XM_006518923.4XP_006518986.1  protein Wnt-5a isoform X1

    Conserved Domains (1) summary
    cd19347
    Location:82393
    Wnt_Wnt5a; Wnt domain found in protein Wnt-5a and similar proteins