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VIPR1 vasoactive intestinal peptide receptor 1 [ Homo sapiens (human) ]

Gene ID: 7433, updated on 7-Dec-2018

Summary

Official Symbol
VIPR1provided by HGNC
Official Full Name
vasoactive intestinal peptide receptor 1provided by HGNC
Primary source
HGNC:HGNC:12694
See related
Ensembl:ENSG00000114812 MIM:192321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
II; HVR1; RDC1; V1RG; VIPR; VIRG; VAPC1; VPAC1; VPAC1R; VIP-R-1; VPCAP1R; PACAP-R2; PACAP-R-2
Summary
This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Expression
Broad expression in lung (RPKM 17.1), duodenum (RPKM 12.7) and 17 other tissues See more
Orthologs

Genomic context

See VIPR1 in Genome Data Viewer
Location:
3p22.1
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 3 NC_000003.12 (42489299..42537573)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (42530791..42579065)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene lysozyme like 4 Neighboring gene ribosomal protein L35a pseudogene 8 Neighboring gene VIPR1 antisense RNA 1 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene SS18 like 2 Neighboring gene uncharacterized LOC101928323 Neighboring gene natural killer cell triggering receptor

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env HIV-1 gp120 has sequence similarity to the natural ligand for VPAC1 and it can activate this receptor directly PubMed
Tat tat HIV-1 Tat downregulates the expression of vasoactive intestinal peptide receptor 1 (VIPR1) in human primary T cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ41949

Gene Ontology Provided by GOA

Function Evidence Code Pubs
G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptide hormone binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
vasoactive intestinal polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
vasoactive intestinal polypeptide receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 
receptor complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
vasoactive intestinal polypeptide receptor 1
Names
PACAP type II receptor
VIP and PACAP receptor 1
VIP receptor, type I
VPAC1 receptor
pituitary adenylate cyclase activating polypeptide receptor, type II
type 1 vasoactive intestinal peptide receptor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_030371.1 RefSeqGene

    Range
    5001..53275
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001251882.1NP_001238811.1  vasoactive intestinal polypeptide receptor 1 isoform 2

    See identical proteins and their annotated locations for NP_001238811.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC092047, AK056819, AK298115, BU681817
    Consensus CDS
    CCDS58828.1
    UniProtKB/Swiss-Prot
    P32241
    UniProtKB/TrEMBL
    A0A024R2N2, B4DNY6
    Related
    ENSP00000394950.1, ENST00000433647.5
    Conserved Domains (2) summary
    smart00008
    Location:1887
    HormR; Domain present in hormone receptors
    pfam00002
    Location:98343
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. NM_001251883.1NP_001238812.1  vasoactive intestinal polypeptide receptor 1 isoform 3

    See identical proteins and their annotated locations for NP_001238812.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate exon in the 5' coding region, uses a downstream start codon, and has multiple differences in the coding region, compared to variant 1. The resulting isoform (3) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC092047, AK293548, AK294609, BU681817
    Consensus CDS
    CCDS58829.1
    UniProtKB/Swiss-Prot
    P32241
    Related
    ENSP00000415371.2, ENST00000438259.6
    Conserved Domains (1) summary
    cl21561
    Location:55174
    7tm_4; Olfactory receptor
  3. NM_001251884.1NP_001238813.1  vasoactive intestinal polypeptide receptor 1 isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks an alternate exon in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (4) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC092047, AK294609, AK298115, BU681817
    Consensus CDS
    CCDS58827.1
    UniProtKB/Swiss-Prot
    P32241
    UniProtKB/TrEMBL
    B4DNY6
    Related
    ENSP00000445701.1, ENST00000543411.5
    Conserved Domains (2) summary
    smart00008
    Location:1481
    HormR; Domain present in hormone receptors
    pfam00002
    Location:91336
    7tm_2; 7 transmembrane receptor (Secretin family)
  4. NM_001251885.1NP_001238814.1  vasoactive intestinal polypeptide receptor 1 isoform 5

    See identical proteins and their annotated locations for NP_001238814.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) lacks an alternate internal segment in the 5' coding region and uses a downstream start codon, compared to variant 1. The resulting isoform (5z) has a shorter and distinct N-terminus compared to isoform 1.
    Source sequence(s)
    AC092047, AK294609, AK298115, BU681817
    UniProtKB/Swiss-Prot
    P32241
    UniProtKB/TrEMBL
    B4DNY6
    Conserved Domains (2) summary
    smart00008
    Location:32101
    HormR; Domain present in hormone receptors
    pfam00002
    Location:112357
    7tm_2; 7 transmembrane receptor (Secretin family)
  5. NM_004624.4NP_004615.2  vasoactive intestinal polypeptide receptor 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_004615.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC092047, BU681817, DA200439, L13288, X75299
    Consensus CDS
    CCDS2698.1
    UniProtKB/Swiss-Prot
    P32241
    Related
    ENSP00000327246.4, ENST00000325123.4
    Conserved Domains (2) summary
    smart00008
    Location:59128
    HormR; Domain present in hormone receptors
    pfam00002
    Location:139384
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p12 Primary Assembly

    Range
    42489299..42537573
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011534079.1XP_011532381.1  vasoactive intestinal polypeptide receptor 1 isoform X2

    See identical proteins and their annotated locations for XP_011532381.1

    UniProtKB/Swiss-Prot
    P32241
    UniProtKB/TrEMBL
    A0A024R2N2
    Conserved Domains (2) summary
    smart00008
    Location:1887
    HormR; Domain present in hormone receptors
    pfam00002
    Location:98343
    7tm_2; 7 transmembrane receptor (Secretin family)
  2. XM_005265438.3XP_005265495.1  vasoactive intestinal polypeptide receptor 1 isoform X2

    See identical proteins and their annotated locations for XP_005265495.1

    UniProtKB/Swiss-Prot
    P32241
    UniProtKB/TrEMBL
    A0A024R2N2
    Conserved Domains (2) summary
    smart00008
    Location:1887
    HormR; Domain present in hormone receptors
    pfam00002
    Location:98343
    7tm_2; 7 transmembrane receptor (Secretin family)
  3. XM_011534080.2XP_011532382.1  vasoactive intestinal polypeptide receptor 1 isoform X4

    Conserved Domains (2) summary
    smart00008
    Location:59128
    HormR; Domain present in hormone receptors
    pfam00002
    Location:139341
    7tm_2; 7 transmembrane receptor (Secretin family)
  4. XM_005265437.2XP_005265494.1  vasoactive intestinal polypeptide receptor 1 isoform X1

    Conserved Domains (2) summary
    smart00008
    Location:59128
    HormR; Domain present in hormone receptors
    pfam00002
    Location:138383
    7tm_2; 7 transmembrane receptor (Secretin family)
  5. XM_005265439.2XP_005265496.1  vasoactive intestinal polypeptide receptor 1 isoform X3

    Conserved Domains (2) summary
    smart00008
    Location:1481
    HormR; Domain present in hormone receptors
    pfam00002
    Location:92337
    7tm_2; 7 transmembrane receptor (Secretin family)

RNA

  1. XR_001740255.1 RNA Sequence

  2. XR_001740254.1 RNA Sequence

  3. XR_940500.2 RNA Sequence

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