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Vipr1 vasoactive intestinal peptide receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 22354, updated on 23-Nov-2023

Summary

Official Symbol
Vipr1provided by MGI
Official Full Name
vasoactive intestinal peptide receptor 1provided by MGI
Primary source
MGI:MGI:109272
See related
Ensembl:ENSMUSG00000032528 AllianceGenome:MGI:109272
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
VPAC1; VIP-R1
Summary
Predicted to enable G protein-coupled peptide receptor activity; peptide hormone binding activity; and vasoactive intestinal polypeptide receptor activity. Predicted to be involved in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger and adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within signal transduction. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be part of receptor complex. Predicted to be active in plasma membrane. Is expressed in brain and cerebral cortex. Human ortholog(s) of this gene implicated in achalasia. Orthologous to human VIPR1 (vasoactive intestinal peptide receptor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in colon adult (RPKM 47.0), small intestine adult (RPKM 34.2) and 8 other tissues See more
Orthologs
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Genomic context

See Vipr1 in Genome Data Viewer
Location:
9 F4; 9 72.5 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2023_04 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (121471782..121502020)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (121642716..121672954)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 38661 Neighboring gene predicted gene, 47095 Neighboring gene lysozyme-like 4 Neighboring gene lysozyme-like 4, opposite strand Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:121591571-121591680 Neighboring gene SEC22 homolog C, vesicle trafficking protein Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled peptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide hormone binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables peptide hormone binding ISO
Inferred from Sequence Orthology
more info
 
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables vasoactive intestinal polypeptide receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables vasoactive intestinal polypeptide receptor activity ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of receptor complex ISO
Inferred from Sequence Orthology
more info
PubMed 

General protein information

Preferred Names
vasoactive intestinal polypeptide receptor 1
Names
PACAP type II receptor
PACAP-R-2
PACAP-R2
VIP receptor subtype 1
VIP-R-1
pituitary adenylate cyclase-activating polypeptide type II receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_011703.4NP_035833.2  vasoactive intestinal polypeptide receptor 1 precursor

    See identical proteins and their annotated locations for NP_035833.2

    Status: VALIDATED

    Source sequence(s)
    AC159810, AK052465, BP762347
    Consensus CDS
    CCDS23633.1
    UniProtKB/Swiss-Prot
    P97751, Q9JI40, Q9R1T8
    Related
    ENSMUSP00000035115.5, ENSMUST00000035115.5
    Conserved Domains (2) summary
    smart00008
    Location:59130
    HormR; Domain present in hormone receptors
    pfam00002
    Location:140386
    7tm_2; 7 transmembrane receptor (Secretin family)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2023_04

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    121471782..121502020
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512068.4XP_006512131.1  vasoactive intestinal polypeptide receptor 1 isoform X1

    Conserved Domains (2) summary
    smart00008
    Location:59130
    HormR; Domain present in hormone receptors
    cd15269
    Location:139406
    7tmB1_VIP-R1; vasoactive intestinal polypeptide (VIP) receptor 1, member of the class B family of seven-transmembrane G protein-coupled receptors