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Dtx2 deltex 2, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

Gene ID: 74198, updated on 27-Feb-2024

Summary

Official Symbol
Dtx2provided by MGI
Official Full Name
deltex 2, E3 ubiquitin ligaseprovided by MGI
Primary source
MGI:MGI:1921448
See related
Ensembl:ENSMUSG00000004947 AllianceGenome:MGI:1921448
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Deltex2; 2610524D08Rik
Summary
Predicted to enable ubiquitin protein ligase activity. Acts upstream of or within Notch signaling pathway. Predicted to be located in nuclear membrane. Predicted to be active in nucleoplasm. Is expressed in several structures, including alimentary system; brain; gonad; nasal cavity epithelium; and pharyngo-tympanic tube. Orthologous to human DTX2 (deltex E3 ubiquitin ligase 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in ovary adult (RPKM 19.1), thymus adult (RPKM 16.3) and 28 other tissues See more
Orthologs
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Genomic context

See Dtx2 in Genome Data Viewer
Location:
5 G2; 5 75.64 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (136023654..136061735)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (135994800..136032881)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1311 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:136438585-136438772 Neighboring gene scavenger receptor cysteine rich family, 4 domains Neighboring gene STARR-seq mESC enhancer starr_14608 Neighboring gene zona pellucida glycoprotein 3 Neighboring gene uroplakin 3B Neighboring gene uroplakin 3B-like Neighboring gene predicted gene, 40347

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (1)  1 citation
  • Endonuclease-mediated (4) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Notch signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within Notch signaling pathway TAS
Traceable Author Statement
more info
PubMed 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane ISO
Inferred from Sequence Orthology
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase DTX2
Names
RING-type E3 ubiquitin transferase DTX2
deltex 2 homolog
mDTX2
protein deltex-2
NP_001243025.1
NP_001243026.1
NP_001243027.1
NP_076231.1
XP_006504569.1
XP_006504570.1
XP_006504571.1
XP_006504573.1
XP_017176609.1
XP_030110708.1
XP_030110709.1
XP_036021447.1
XP_036021448.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001256096.1NP_001243025.1  probable E3 ubiquitin-protein ligase DTX2 isoform 1

    See identical proteins and their annotated locations for NP_001243025.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AK012137, BB428288, CF913708
    Consensus CDS
    CCDS57389.1
    UniProtKB/Swiss-Prot
    Q8R3P2, Q9CZV3, Q9ER07, Q9ER08
    Related
    ENSMUSP00000106772.3, ENSMUST00000111142.9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    PHA03247
    Location:204392
    PHA03247; large tegument protein UL36; Provisional
    cd16672
    Location:408479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:477611
    DTC; Deltex C-terminal domain
  2. NM_001256097.1NP_001243026.1  probable E3 ubiquitin-protein ligase DTX2 isoform 3

    See identical proteins and their annotated locations for NP_001243026.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an additional exon in the 5' UTR and lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
    Source sequence(s)
    AK044105, BB428288, CF913708
    Consensus CDS
    CCDS57390.1
    UniProtKB/Swiss-Prot
    Q8R3P2
    Related
    ENSMUSP00000106774.2, ENSMUST00000111144.8
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16672
    Location:362433
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:431565
    DTC; Deltex C-terminal domain
  3. NM_001256098.1NP_001243027.1  probable E3 ubiquitin-protein ligase DTX2 isoform 3

    See identical proteins and their annotated locations for NP_001243027.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon in the coding region, compared to variant 1. The resulting isoform (3) lacks an internal segment, compared to isoform 1. Variants 3 and 4 encode the same isoform 3.
    Source sequence(s)
    AK054443, BB428288, CF913708
    Consensus CDS
    CCDS57390.1
    UniProtKB/Swiss-Prot
    Q8R3P2
    Related
    ENSMUSP00000106775.4, ENSMUST00000111145.10
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16672
    Location:362433
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:431565
    DTC; Deltex C-terminal domain
  4. NM_023742.2NP_076231.1  probable E3 ubiquitin-protein ligase DTX2 isoform 2

    See identical proteins and their annotated locations for NP_076231.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate splice site in the coding region, but maintains the reading frame, compared to variant 1. The resulting isoform (2) lacks an internal aa, compared to isoform 1.
    Source sequence(s)
    AB015423, BB443180, CF913708
    Consensus CDS
    CCDS39322.1
    UniProtKB/TrEMBL
    A0A0R4IZY1
    Related
    ENSMUSP00000005072.4, ENSMUST00000005072.10
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:477609
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd00162
    Location:407470
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    136023654..136061735
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030254848.2XP_030110708.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q8R3P2, Q9CZV3, Q9ER07, Q9ER08
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    PHA03247
    Location:204392
    PHA03247; large tegument protein UL36; Provisional
    cd16672
    Location:408479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:477611
    DTC; Deltex C-terminal domain
  2. XM_036165555.1XP_036021448.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16672
    Location:362433
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:431565
    DTC; Deltex C-terminal domain
  3. XM_006504508.2XP_006504571.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_006504571.1

    UniProtKB/Swiss-Prot
    Q8R3P2, Q9CZV3, Q9ER07, Q9ER08
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    PHA03247
    Location:204392
    PHA03247; large tegument protein UL36; Provisional
    cd16672
    Location:408479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:477611
    DTC; Deltex C-terminal domain
  4. XM_030254849.2XP_030110709.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16672
    Location:362433
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:431565
    DTC; Deltex C-terminal domain
  5. XM_036165554.1XP_036021447.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16672
    Location:362433
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:431565
    DTC; Deltex C-terminal domain
  6. XM_006504507.3XP_006504570.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_006504570.1

    UniProtKB/Swiss-Prot
    Q8R3P2, Q9CZV3, Q9ER07, Q9ER08
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    PHA03247
    Location:204392
    PHA03247; large tegument protein UL36; Provisional
    cd16672
    Location:408479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:477611
    DTC; Deltex C-terminal domain
  7. XM_006504506.3XP_006504569.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_006504569.1

    UniProtKB/Swiss-Prot
    Q8R3P2, Q9CZV3, Q9ER07, Q9ER08
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    PHA03247
    Location:204392
    PHA03247; large tegument protein UL36; Provisional
    cd16672
    Location:408479
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:477611
    DTC; Deltex C-terminal domain
  8. XM_017321120.1XP_017176609.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/Swiss-Prot
    Q8R3P2
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd16672
    Location:362433
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:431565
    DTC; Deltex C-terminal domain
  9. XM_006504510.4XP_006504573.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

    Conserved Domains (2) summary
    cd16672
    Location:114185
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    pfam18102
    Location:183317
    DTC; Deltex C-terminal domain