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DTX2 deltex E3 ubiquitin ligase 2 [ Homo sapiens (human) ]

Gene ID: 113878, updated on 11-Jun-2025
Official Symbol
DTX2provided by HGNC
Official Full Name
deltex E3 ubiquitin ligase 2provided by HGNC
Primary source
HGNC:HGNC:15973
See related
Ensembl:ENSG00000091073 MIM:613141; AllianceGenome:HGNC:15973
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF58
Summary
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Expression
Broad expression in esophagus (RPKM 8.4), testis (RPKM 7.2) and 25 other tissues See more
Orthologs
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See DTX2 in Genome Data Viewer
Location:
7q11.23
Exon count:
16
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (76461709..76505991)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (77750196..77797419)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76091026..76135308)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:75993799-75994486 Neighboring gene peptidylprolyl isomerase A pseudogene 81 Neighboring gene H3K27ac-H3K4me1 hESC enhancers GRCh37_chr7:76008919-76009532 and GRCh37_chr7:76009533-76010146 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76018334-76019171 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76019172-76020008 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18315 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18316 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26200 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76035061-76035561 Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene zona pellucida glycoprotein 3 Neighboring gene Sharpr-MPRA regulatory region 7220 Neighboring gene Sharpr-MPRA regulatory region 8731 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76073005-76073916 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:76073917-76074826 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76085525-76086398 Neighboring gene farnesyl diphosphate synthase pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76114631-76115532 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76115533-76116434 Neighboring gene uncharacterized LOC124901675 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:76138251-76138456 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76139334-76139906 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76139907-76140479 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76141233-76141884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76141885-76142536 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:76142537-76143186 Neighboring gene uroplakin 3B Neighboring gene speedy/RINGO cell cycle regulator family member E16

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
Products Interactant Other Gene Complex Source Pubs Description

Markers

Clone Names

  • KIAA1528, MGC71098

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in Notch signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear membrane IDA
Inferred from Direct Assay
more info
 
is_active_in nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 
Preferred Names
probable E3 ubiquitin-protein ligase DTX2
Names
RING-type E3 ubiquitin transferase DTX2
deltex 2, E3 ubiquitin ligase
deltex homolog 2
deltex2
hDTX2
protein deltex-2
ring finger protein 58
zinc ion binding protein
NP_001096064.1
NP_001096065.1
NP_001096066.1
NP_065943.2
XP_011514076.1
XP_016867213.1
XP_016867215.1
XP_016867219.1
XP_024302417.1
XP_047275808.1
XP_047275809.1
XP_047275810.1
XP_047275811.1
XP_047275812.1
XP_047275813.1
XP_047275814.1
XP_047275815.1
XP_047275816.1
XP_047275817.1
XP_047275818.1
XP_054213158.1
XP_054213159.1
XP_054213160.1
XP_054213161.1
XP_054213162.1
XP_054213163.1
XP_054213164.1
XP_054213165.1
XP_054213166.1
XP_054213167.1
XP_054213168.1
XP_054213169.1
XP_054213170.1
XP_054213171.1
XP_054213172.1
XP_054213173.1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102594.3NP_001096064.1  probable E3 ubiquitin-protein ligase DTX2 isoform a

    See identical proteins and their annotated locations for NP_001096064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1-3 encode the same isoform (A).
    Source sequence(s)
    AB040961, AY225124, BC008856, BC018555, DA003606
    Consensus CDS
    CCDS5587.1
    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
    Related
    ENSP00000411986.2, ENST00000430490.7
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  2. NM_001102595.3NP_001096065.1  probable E3 ubiquitin-protein ligase DTX2 isoform a

    See identical proteins and their annotated locations for NP_001096065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1-3 encode the same isoform (A).
    Source sequence(s)
    AY225124, BC008856, BC018555, DA003606
    Consensus CDS
    CCDS5587.1
    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
    Related
    ENSP00000390218.2, ENST00000413936.6
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  3. NM_001102596.2NP_001096066.1  probable E3 ubiquitin-protein ligase DTX2 isoform b

    See identical proteins and their annotated locations for NP_001096066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (B), compared to isoform A.
    Source sequence(s)
    AY225125, BC008856, BP306192
    Consensus CDS
    CCDS43605.1
    UniProtKB/TrEMBL
    E7ET89
    Related
    ENSP00000392545.2, ENST00000446820.6
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:434566
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:364435
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
  4. NM_020892.4NP_065943.2  probable E3 ubiquitin-protein ligase DTX2 isoform a

    See identical proteins and their annotated locations for NP_065943.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1-3 encode the same isoform (A).
    Source sequence(s)
    AY225124, BC008856, BC018555, DA917716
    Consensus CDS
    CCDS5587.1
    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
    Related
    ENSP00000322885.5, ENST00000324432.9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    76461709..76505991
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047419856.1XP_047275812.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
  2. XM_047419854.1XP_047275810.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
  3. XM_047419855.1XP_047275811.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
  4. XM_047419853.1XP_047275809.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
  5. XM_047419860.1XP_047275816.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

    UniProtKB/TrEMBL
    E7ET89
  6. XM_047419858.1XP_047275814.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/TrEMBL
    E7ET89
  7. XM_047419862.1XP_047275818.1  probable E3 ubiquitin-protein ligase DTX2 isoform X4

    UniProtKB/TrEMBL
    E7ET89
  8. XM_017011726.3XP_016867215.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/TrEMBL
    E7ET89
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:434566
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:364435
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
  9. XM_047419857.1XP_047275813.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
  10. XM_047419861.1XP_047275817.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
  11. XM_011515774.2XP_011514076.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_011514076.1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  12. XM_047419852.1XP_047275808.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
  13. XM_047419859.1XP_047275815.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/TrEMBL
    E7ET89
  14. XM_024446649.2XP_024302417.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  15. XM_017011730.3XP_016867219.1  probable E3 ubiquitin-protein ligase DTX2 isoform X5

  16. XM_017011724.2XP_016867213.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q4ZH49, Q6XM87, Q6XM88, Q86UW9, Q96H69, Q9H890, Q9P200
    UniProtKB/TrEMBL
    E7ET89
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family

Reference GRCh38.p14 ALT_REF_LOCI_1

Genomic

  1. NT_187561.1 Reference GRCh38.p14 ALT_REF_LOCI_1

    Range
    1310..5010
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    77750196..77797419
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054357187.1XP_054213162.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  2. XM_054357185.1XP_054213160.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  3. XM_054357188.1XP_054213163.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  4. XM_054357184.1XP_054213159.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  5. XM_054357195.1XP_054213170.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

    UniProtKB/TrEMBL
    E7ET89
  6. XM_054357192.1XP_054213167.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/TrEMBL
    E7ET89
  7. XM_054357196.1XP_054213171.1  probable E3 ubiquitin-protein ligase DTX2 isoform X4

    UniProtKB/TrEMBL
    E7ET89
  8. XM_054357193.1XP_054213168.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/TrEMBL
    E7ET89
  9. XM_054357189.1XP_054213164.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  10. XM_054357191.1XP_054213166.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  11. XM_054357183.1XP_054213158.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  12. XM_054357194.1XP_054213169.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/TrEMBL
    E7ET89
  13. XM_054357190.1XP_054213165.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89
  14. XM_054357197.1XP_054213172.1  probable E3 ubiquitin-protein ligase DTX2 isoform X6

  15. XM_054357198.1XP_054213173.1  probable E3 ubiquitin-protein ligase DTX2 isoform X5

  16. XM_054357186.1XP_054213161.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/TrEMBL
    E7ET89