Format

Send to:

Choose Destination

DTX2 deltex E3 ubiquitin ligase 2 [ Homo sapiens (human) ]

Gene ID: 113878, updated on 13-Mar-2020

Summary

Official Symbol
DTX2provided by HGNC
Official Full Name
deltex E3 ubiquitin ligase 2provided by HGNC
Primary source
HGNC:HGNC:15973
See related
Ensembl:ENSG00000091073 MIM:613141
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RNF58
Summary
DTX2 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Expression
Broad expression in esophagus (RPKM 8.4), testis (RPKM 7.2) and 25 other tissues See more
Orthologs

Genomic context

See DTX2 in Genome Data Viewer
Location:
7q11.23
Exon count:
17
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (76461655..76505995)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (76090972..76135312)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene scavenger receptor cysteine rich family member with 4 domains Neighboring gene zona pellucida glycoprotein 3 Neighboring gene Sharpr-MPRA regulatory region 7220 Neighboring gene farnesyl diphosphate synthase pseudogene 2 Neighboring gene uroplakin 3B Neighboring gene speedy/RINGO cell cycle regulator family member E16

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1528, MGC71098

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
Notch signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
nuclear membrane IDA
Inferred from Direct Assay
more info
 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
probable E3 ubiquitin-protein ligase DTX2
Names
RING-type E3 ubiquitin transferase DTX2
deltex 2, E3 ubiquitin ligase
deltex homolog 2
deltex2
hDTX2
protein deltex-2
ring finger protein 58
zinc ion binding protein
NP_001096064.1
NP_001096065.1
NP_001096066.1
NP_065943.2
XP_005250188.1
XP_005250189.1
XP_011514074.1
XP_011514075.1
XP_011514076.1
XP_011514077.1
XP_016867212.1
XP_016867213.1
XP_016867214.1
XP_016867215.1
XP_016867216.1
XP_016867218.1
XP_016867219.1
XP_024302417.1
XP_024302418.1
XP_024302419.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001102594.1NP_001096064.1  probable E3 ubiquitin-protein ligase DTX2 isoform a

    See identical proteins and their annotated locations for NP_001096064.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1-3 encode the same isoform (A).
    Source sequence(s)
    AB040961, AK026252, AY225124, BC008856, BC018555, DA003606
    Consensus CDS
    CCDS5587.1
    UniProtKB/Swiss-Prot
    Q86UW9
    Related
    ENSP00000411986.2, ENST00000430490.6
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  2. NM_001102595.1NP_001096065.1  probable E3 ubiquitin-protein ligase DTX2 isoform a

    See identical proteins and their annotated locations for NP_001096065.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1, and encodes isoform A. Variants 1-3 encode the same isoform (A).
    Source sequence(s)
    AK026252, AY225124, BC008856, BC018555, DA003606
    Consensus CDS
    CCDS5587.1
    UniProtKB/Swiss-Prot
    Q86UW9
    Related
    ENSP00000390218.2, ENST00000413936.6
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  3. NM_001102596.2NP_001096066.1  probable E3 ubiquitin-protein ligase DTX2 isoform b

    See identical proteins and their annotated locations for NP_001096066.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an in-frame exon, compared to variant 1, and encodes a shorter isoform (B), compared to isoform A.
    Source sequence(s)
    AY225125, BC008856, BP306192
    Consensus CDS
    CCDS43605.1
    UniProtKB/Swiss-Prot
    Q86UW9
    Related
    ENSP00000392545.2, ENST00000446820.6
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:434566
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:364435
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
  4. NM_020892.2NP_065943.2  probable E3 ubiquitin-protein ligase DTX2 isoform a

    See identical proteins and their annotated locations for NP_065943.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (A). Variants 1-3 encode the same isoform (A).
    Source sequence(s)
    AK026252, AY225124, BC008856, BC018555, DA003606, DA917716
    Consensus CDS
    CCDS5587.1
    UniProtKB/Swiss-Prot
    Q86UW9
    Related
    ENSP00000322885.5, ENST00000324432.9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    76461655..76505995
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250131.2XP_005250188.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_005250188.1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  2. XM_017011726.2XP_016867215.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:434566
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:364435
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
  3. XM_011515774.1XP_011514076.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_011514076.1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  4. XM_017011727.1XP_016867216.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:434566
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:364435
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
  5. XM_024446649.1XP_024302417.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  6. XM_017011723.1XP_016867212.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  7. XM_011515775.1XP_011514077.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_011514077.1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  8. XM_017011725.1XP_016867214.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  9. XM_011515772.1XP_011514074.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_011514074.1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  10. XM_011515773.2XP_011514075.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_011514075.1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  11. XM_017011724.1XP_016867213.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  12. XM_024446651.1XP_024302419.1  probable E3 ubiquitin-protein ligase DTX2 isoform X3

    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:460559
    Deltex_C; Domain found at the C-terminus of deltex-like
    cl17238
    Location:411463
    RING_Ubox; The superfamily of RING finger (Really Interesting New Gene) domain and U-box domain
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family
  13. XM_024446650.1XP_024302418.1  probable E3 ubiquitin-protein ligase DTX2 isoform X2

    Conserved Domains (3) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:434566
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:364435
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
  14. XM_017011730.2XP_016867219.1  probable E3 ubiquitin-protein ligase DTX2 isoform X5

  15. XM_017011729.2XP_016867218.1  probable E3 ubiquitin-protein ligase DTX2 isoform X4

  16. XM_005250132.2XP_005250189.1  probable E3 ubiquitin-protein ligase DTX2 isoform X1

    See identical proteins and their annotated locations for XP_005250189.1

    UniProtKB/Swiss-Prot
    Q86UW9
    Conserved Domains (4) summary
    smart00678
    Location:21105
    WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
    cd09633
    Location:481613
    Deltex_C; Domain found at the C-terminus of deltex-like
    cd16672
    Location:411482
    RING-H2_DTX2; RING finger, H2 subclass, found in E3 ubiquitin-protein ligase Deltex2 (DTX2) and similar proteins
    cl26464
    Location:166394
    Atrophin-1; Atrophin-1 family

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NT_187561.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    1310..5014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center