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UQCRFS1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [ Homo sapiens (human) ]

Gene ID: 7386, updated on 3-Jan-2019

Summary

Official Symbol
UQCRFS1provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1provided by HGNC
Primary source
HGNC:HGNC:12587
See related
Ensembl:ENSG00000169021 MIM:191327
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RIP1; RIS1; RISP; UQCR5
Expression
Ubiquitous expression in heart (RPKM 101.2), kidney (RPKM 70.7) and 25 other tissues See more
Orthologs

Genomic context

See UQCRFS1 in Genome Data Viewer
Location:
19q12
Exon count:
2
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 19 NC_000019.10 (29207260..29213229, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (29698167..29704136, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene RNA, 5S ribosomal pseudogene 470 Neighboring gene long intergenic non-protein coding RNA 1532 Neighboring gene uncharacterized LOC105372352 Neighboring gene RNA, 7SL, cytoplasmic 340, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 (UQCRFS1) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to ubiquinol-cytochrome-c reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial respiratory chain complex III IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial respiratory chain complex IV IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion HDA PubMed 
mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytochrome b-c1 complex subunit Rieske, mitochondrial
Names
Rieske iron-sulfur protein
Rieske protein UQCRFS1
complex III subunit 5
cytochrome b-c1 complex subunit 5
epididymis secretory sperm binding protein
ubiquinol-cytochrome c reductase iron-sulfur subunit
NP_005994.2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_006003.3NP_005994.2  cytochrome b-c1 complex subunit Rieske, mitochondrial

    See identical proteins and their annotated locations for NP_005994.2

    Status: VALIDATED

    Source sequence(s)
    AC007786, BC010035, BF210184, BF979273
    Consensus CDS
    CCDS12415.1
    UniProtKB/Swiss-Prot
    P47985
    Related
    ENSP00000306397.3, ENST00000304863.5
    Conserved Domains (4) summary
    cd03470
    Location:151274
    Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
    TIGR01416
    Location:110274
    Rieske_proteo; ubiquinol-cytochrome c reductase, iron-sulfur subunit
    pfam02921
    Location:80145
    UCR_TM; Ubiquinol cytochrome reductase transmembrane region
    pfam09165
    Location:276
    Ubiq-Cytc-red_N; Ubiquinol-cytochrome c reductase 8 kDa, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p12 Primary Assembly

    Range
    29207260..29213229 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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