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Uqcrfs1 ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1 [ Mus musculus (house mouse) ]

Gene ID: 66694, updated on 12-May-2024

Summary

Official Symbol
Uqcrfs1provided by MGI
Official Full Name
ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1provided by MGI
Primary source
MGI:MGI:1913944
See related
Ensembl:ENSMUSG00000038462 AllianceGenome:MGI:1913944
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
4430402G14Rik
Summary
Predicted to enable oxidoreductase activity. Predicted to be involved in mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including alimentary system; cardiovascular system; hemolymphoid system; and liver. Used to study mitochondrial metabolism disease. Human ortholog(s) of this gene implicated in mitochondrial complex III deficiency. Orthologous to several human genes including UQCRFS1 (ubiquinol-cytochrome c reductase, Rieske iron-sulfur polypeptide 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in adrenal adult (RPKM 429.8), duodenum adult (RPKM 371.7) and 28 other tissues See more
Orthologs
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Genomic context

See Uqcrfs1 in Genome Data Viewer
Location:
13 A3.2; 13 13.23 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (30724295..30729299, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (30540312..30545316, complement)

Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene membrane bound O-acyltransferase domain containing 1 Neighboring gene STARR-seq mESC enhancer starr_34065 Neighboring gene predicted gene, 53782 Neighboring gene angiotensin II receptor, type 1a Neighboring gene STARR-seq mESC enhancer starr_34066 Neighboring gene STARR-seq mESC enhancer starr_34067 Neighboring gene STARR-seq mESC enhancer starr_34068 Neighboring gene RIKEN cDNA 4930519D14 gene Neighboring gene predicted gene, 35109

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (1) 
  • Targeted (3)  1 citation

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2 iron, 2 sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables iron-sulfur cluster binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables oxidoreductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquinol-cytochrome-c reductase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in mitochondrial electron transport, ubiquinol to cytochrome c IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial inner membrane HDA PubMed 
located_in mitochondrial membrane ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex III IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of mitochondrial respiratory chain complex III ISO
Inferred from Sequence Orthology
more info
 
part_of mitochondrial respiratory chain complex IV ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
 
located_in myelin sheath HDA PubMed 
located_in respirasome IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome b-c1 complex subunit Rieske, mitochondrial
Names
RISP
Rieske protein UQCRFS1
complex III subunit 5
cytochrome b-c1 complex subunit 5
rieske iron-sulfur protein
ubiquinol-cytochrome c reductase iron-sulfur subunit
NP_079986.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_025710.2NP_079986.1  cytochrome b-c1 complex subunit Rieske, mitochondrial

    See identical proteins and their annotated locations for NP_079986.1

    Status: PROVISIONAL

    Source sequence(s)
    AK014470
    Consensus CDS
    CCDS26416.1
    UniProtKB/Swiss-Prot
    Q5SVV1, Q9CR68
    Related
    ENSMUSP00000045284.4, ENSMUST00000042834.4
    Conserved Domains (3) summary
    cd03470
    Location:151274
    Rieske_cytochrome_bc1; Iron-sulfur protein (ISP) component of the bc(1) complex family, Rieske domain; The Rieske domain is a [2Fe-2S] cluster binding domain involved in electron transfer. The bc(1) complex is a multisubunit enzyme found in many different organisms including ...
    pfam02921
    Location:80145
    UCR_TM; Ubiquinol cytochrome reductase transmembrane region
    pfam09165
    Location:277
    Ubiq-Cytc-red_N; Ubiquinol-cytochrome c reductase 8 kDa, N-terminal

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000079.7 Reference GRCm39 C57BL/6J

    Range
    30724295..30729299 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)