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UQCRC1 ubiquinol-cytochrome c reductase core protein 1 [ Homo sapiens (human) ]

Gene ID: 7384, updated on 22-Sep-2022

Summary

Official Symbol
UQCRC1provided by HGNC
Official Full Name
ubiquinol-cytochrome c reductase core protein 1provided by HGNC
Primary source
HGNC:HGNC:12585
See related
Ensembl:ENSG00000010256 MIM:191328; AllianceGenome:HGNC:12585
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
QCR1; PKNPY; UQCR1; D3S3191
Summary
Enables ubiquitin protein ligase binding activity. Predicted to be involved in oxidative phosphorylation. Predicted to act upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Implicated in Alzheimer's disease. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in heart (RPKM 170.6), kidney (RPKM 96.0) and 25 other tissues See more
Orthologs
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Genomic context

See UQCRC1 in Genome Data Viewer
Location:
3p21.31
Exon count:
13
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (48599002..48609646, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (48627962..48638607, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (48636435..48647079, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 Neighboring gene collagen type VII alpha 1 chain Neighboring gene urocortin 2 Neighboring gene microRNA 711 Neighboring gene small nucleolar RNA, H/ACA box 94 Neighboring gene transmembrane protein 89 Neighboring gene solute carrier family 26 member 6 Neighboring gene microRNA 6824

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of ubiquinol-cytochrome c reductase core protein I (UQCRC1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables ubiquinol-cytochrome-c reductase activity TAS
Traceable Author Statement
more info
PubMed 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in mitochondrial inner membrane TAS
Traceable Author Statement
more info
 
located_in mitochondrial respirasome TAS
Traceable Author Statement
more info
PubMed 
part_of mitochondrial respiratory chain complex III IPI
Inferred from Physical Interaction
more info
PubMed 
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
cytochrome b-c1 complex subunit 1, mitochondrial
Names
complex III subunit 1
core protein I
ubiquinol-cytochrome c reductase core protein I
ubiquinol-cytochrome-c reductase complex core protein 1
NP_003356.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_003365.3NP_003356.2  cytochrome b-c1 complex subunit 1, mitochondrial precursor

    See identical proteins and their annotated locations for NP_003356.2

    Status: VALIDATED

    Source sequence(s)
    AA284910, AK129903, L16842
    Consensus CDS
    CCDS2774.1
    UniProtKB/Swiss-Prot
    P31930, Q96DD2
    Related
    ENSP00000203407.5, ENST00000203407.6
    Conserved Domains (1) summary
    COG0612
    Location:41469
    PqqL; Predicted Zn-dependent peptidase [General function prediction only]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    48599002..48609646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    48627962..48638607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)