Uqcrc1 ubiquinol-cytochrome c reductase core protein 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Uqcrc1provided by MGI
Official Full Name: ubiquinol-cytochrome c reductase core protein 1provided by MGI
Primary source: MGI:MGI:107876
See related: Ensembl:ENSMUSG00000025651 AllianceGenome:MGI:107876
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 1110032G10Rik
Summary: Predicted to enable ubiquitin protein ligase binding activity. Acts upstream of or within mitochondrial electron transport, ubiquinol to cytochrome c. Located in mitochondrion. Is expressed in several structures, including alimentary system; central nervous system; metanephros; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human UQCRC1 (ubiquinol-cytochrome c reductase core protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in heart adult (RPKM 872.4), duodenum adult (RPKM 565.1) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 F2; 9 59.63 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (108765716..108778709)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (108936648..108949641)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
Title: Ubiquinol-cytochrome c reductase core protein 1 contributes to cardiac tolerance to acute exhaustive exercise.
Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
Title: Mitochondrial Protein UQCRC1 is Oncogenic and a Potential Therapeutic Target for Pancreatic Cancer.
UQCRC1 is critical for the development and survival of embryos. UQCRC1 is also important for the proper function of the complex III, which may affect the brain ischemic tolerance and normal learning and memory.
Title: Critical role of UQCRC1 in embryo survival, brain ischemic tolerance and normal cognition in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (1)
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Uqcrc1 (e-PCR), detects polymorphism
- UniSTS:144735

Uqcrc1 (e-PCR), detects polymorphism
- UniSTS:507305

AA819271 (e-PCR)
- UniSTS:243443

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	IEA Inferred from Electronic Annotation more info
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular respiration	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within mitochondrial electron transport, ubiquinol to cytochrome c	IDA Inferred from Direct Assay more info	PubMed
involved_in mitochondrial electron transport, ubiquinol to cytochrome c	NAS Non-traceable Author Statement more info	PubMed
involved_in mitochondrial respiratory chain complex III assembly	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to activity	IEA Inferred from Electronic Annotation more info
involved_in response to alkaloid	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial inner membrane	HDA more info	PubMed
located_in mitochondrial inner membrane	ISO Inferred from Sequence Orthology more info
located_in mitochondrion	HDA more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	ISO Inferred from Sequence Orthology more info
located_in myelin sheath	HDA more info	PubMed
part_of respiratory chain complex III	IEA Inferred from Electronic Annotation more info
part_of respiratory chain complex III	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: cytochrome b-c1 complex subunit 1, mitochondrial

Names: complex III subunit 1; core protein I; ubiquinol-cytochrome-c reductase complex core protein 1

NP_079683.2

EC 7.1.1.8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025407.2 → NP_079683.2 cytochrome b-c1 complex subunit 1, mitochondrial precursor

See identical proteins and their annotated locations for NP_079683.2

Status: VALIDATED

Source sequence(s)

AI462428, AK010553, BB649589, BY260300

Consensus CDS

CCDS23540.1

UniProtKB/Swiss-Prot

Q3TV75, Q9CWL6, Q9CZ13

UniProtKB/TrEMBL

Q3TIC8

Related

ENSMUSP00000026743.9, ENSMUST00000026743.14

Conserved Domains (3) summary

COG0612
Location:46 → 469

PqqL; Predicted Zn-dependent peptidase [General function prediction only]

pfam00675
Location:58 → 205

Peptidase_M16; Insulinase (Peptidase family M16)

pfam05193
Location:210 → 395

Peptidase_M16_C; Peptidase M16 inactive domain