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UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 [ Homo sapiens (human) ]

Gene ID: 7311, updated on 12-Feb-2021

Summary

Official Symbol
UBA52provided by HGNC
Official Full Name
ubiquitin A-52 residue ribosomal protein fusion product 1provided by HGNC
Primary source
HGNC:HGNC:12458
See related
Ensembl:ENSG00000221983 MIM:191321
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L40; CEP52; RPL40; HUBCEP52
Summary
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 89.0), bone marrow (RPKM 83.5) and 25 other tissues See more
Orthologs
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Genomic context

See UBA52 in Genome Data Viewer
Location:
19p13.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (18563766..18577550)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18682534..18688360)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene elongation factor for RNA polymerase II Neighboring gene Sharpr-MPRA regulatory region 11651 Neighboring gene FKBP prolyl isomerase 8 Neighboring gene KxDL motif containing 1 Neighboring gene Sharpr-MPRA regulatory region 11645 Neighboring gene required for excision 1-B domain containing Neighboring gene cytokine receptor like factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated ubiquitin A-52 residue ribosomal protein fusion product 1 protein (UBA52, ubiquitin-60S ribosomal protein L40) is incorporated into HIV-1 Gag virus-like particles PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of ubiquitin A-52 ribosomal protein fusion product 1 (UBA52, RPL40) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC57125, MGC126879, MGC126881

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tag IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
structural constituent of ribosome IEA
Inferred from Electronic Annotation
more info
 
ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
DNA damage response, detection of DNA damage TAS
Traceable Author Statement
more info
 
I-kappaB kinase/NF-kappaB signaling TAS
Traceable Author Statement
more info
 
JNK cascade TAS
Traceable Author Statement
more info
 
MyD88-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
MyD88-independent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
SRP-dependent cotranslational protein targeting to membrane TAS
Traceable Author Statement
more info
 
TRIF-dependent toll-like receptor signaling pathway TAS
Traceable Author Statement
more info
 
Wnt signaling pathway TAS
Traceable Author Statement
more info
 
activation of MAPK activity TAS
Traceable Author Statement
more info
 
anaphase-promoting complex-dependent catabolic process TAS
Traceable Author Statement
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular protein modification process TAS
Traceable Author Statement
more info
 
cytokine-mediated signaling pathway TAS
Traceable Author Statement
more info
 
endosomal transport TAS
Traceable Author Statement
more info
 
error-free translesion synthesis TAS
Traceable Author Statement
more info
 
error-prone translesion synthesis TAS
Traceable Author Statement
more info
 
global genome nucleotide-excision repair TAS
Traceable Author Statement
more info
 
interleukin-1-mediated signaling pathway TAS
Traceable Author Statement
more info
 
interstrand cross-link repair TAS
Traceable Author Statement
more info
 
intracellular transport of virus TAS
Traceable Author Statement
more info
 
membrane organization TAS
Traceable Author Statement
more info
 
modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of apoptotic process TAS
Traceable Author Statement
more info
 
negative regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
negative regulation of transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
nuclear-transcribed mRNA catabolic process, nonsense-mediated decay TAS
Traceable Author Statement
more info
 
nucleotide-binding oligomerization domain containing signaling pathway TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA damage recognition TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA duplex unwinding TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA gap filling TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, DNA incision, 5'-to lesion TAS
Traceable Author Statement
more info
 
nucleotide-excision repair, preincision complex assembly TAS
Traceable Author Statement
more info
 
positive regulation of NF-kappaB transcription factor activity TAS
Traceable Author Statement
more info
 
positive regulation of apoptotic process TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II TAS
Traceable Author Statement
more info
 
protein deubiquitination TAS
Traceable Author Statement
more info
 
protein polyubiquitination TAS
Traceable Author Statement
more info
 
protein targeting to peroxisome TAS
Traceable Author Statement
more info
 
protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein ubiquitination TAS
Traceable Author Statement
more info
 
regulation of mRNA stability TAS
Traceable Author Statement
more info
 
regulation of transcription from RNA polymerase II promoter in response to hypoxia TAS
Traceable Author Statement
more info
 
stress-activated MAPK cascade TAS
Traceable Author Statement
more info
 
transcription-coupled nucleotide-excision repair TAS
Traceable Author Statement
more info
 
transforming growth factor beta receptor signaling pathway TAS
Traceable Author Statement
more info
 
translational initiation TAS
Traceable Author Statement
more info
 
translesion synthesis TAS
Traceable Author Statement
more info
 
transmembrane transport TAS
Traceable Author Statement
more info
 
viral life cycle TAS
Traceable Author Statement
more info
 
viral transcription TAS
Traceable Author Statement
more info
 
virion assembly TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endosome membrane TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular space HDA PubMed 
host cell IEA
Inferred from Electronic Annotation
more info
 
lysosomal membrane HDA PubMed 
mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
vesicle HDA PubMed 

General protein information

Preferred Names
ubiquitin-60S ribosomal protein L40
Names
ubiquitin carboxyl extension protein 52
ubiquitin-52 amino acid fusion protein
ubiquitin-CEP52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023288.1 RefSeqGene

    Range
    5054..10747
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033930.3NP_001029102.1  ubiquitin-60S ribosomal protein L40 isoform 1 precursor

    See identical proteins and their annotated locations for NP_001029102.1

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BQ428515, BQ428688, BU677484, CB124676
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P62987
    UniProtKB/TrEMBL
    Q3MIH3, Q7Z4P3
    Related
    ENSP00000388107.1, ENST00000442744.7
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  2. NM_001321017.2NP_001307946.1  ubiquitin-60S ribosomal protein L40 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BQ428515, BU677484, DA949569
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P62987
    UniProtKB/TrEMBL
    Q3MIH3, Q7Z4P3
    Related
    ENSP00000472264.1, ENST00000596304.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  3. NM_001321018.2NP_001307947.1  ubiquitin-60S ribosomal protein L40 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BG035502, BQ428515, BU677484, CD242660
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P62987
    UniProtKB/TrEMBL
    Q3MIH3, Q7Z4P3
    Related
    ENSP00000470419.1, ENST00000595683.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  4. NM_001321019.2NP_001307948.1  ubiquitin-60S ribosomal protein L40 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BG035502, BQ428515, BU677484, CD385706
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P62987
    UniProtKB/TrEMBL
    Q3MIH3, Q7Z4P3
    Related
    ENSP00000471622.1, ENST00000595158.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  5. NM_001321020.2NP_001307949.1  ubiquitin-60S ribosomal protein L40 isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BE514609, BG035502, BQ428515, BU677484
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P62987
    UniProtKB/TrEMBL
    Q3MIH3, Q7Z4P3
    Related
    ENSP00000472545.1, ENST00000598780.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  6. NM_001321021.1NP_001307950.1  ubiquitin-60S ribosomal protein L40 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and initiates translation at an alternate start site, compared to variant 1. It encodes isoform 2, which has a longer N-terminus compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC005253, AF545864, BG341101, BQ428515, BU677484
    UniProtKB/TrEMBL
    Q7Z4P3
    Conserved Domains (2) summary
    cd01803
    Location:883
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:86133
    Ribosomal_L40e; Ribosomal L40e family
  7. NM_001321022.2NP_001307951.1  ubiquitin-60S ribosomal protein L40 isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BG341101, BQ428515, BU677484, HY153317
    UniProtKB/TrEMBL
    Q7Z4P3
    Conserved Domains (2) summary
    pfam01020
    Location:5097
    Ribosomal_L40e; Ribosomal L40e family
    cl28922
    Location:147
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  8. NM_003333.5NP_003324.1  ubiquitin-60S ribosomal protein L40 isoform 1 precursor

    See identical proteins and their annotated locations for NP_003324.1

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF348700, AF545864, BQ428515, BQ428688, BU677484
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P62987
    UniProtKB/TrEMBL
    Q3MIH3, Q7Z4P3
    Related
    ENSP00000396910.1, ENST00000430157.6
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    18563766..18577550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260054.2XP_005260111.1  ubiquitin-60S ribosomal protein L40 isoform X2

    See identical proteins and their annotated locations for XP_005260111.1

    Related
    ENSP00000472768.1, ENST00000596272.5
    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  2. XM_005260053.3XP_005260110.1  ubiquitin-60S ribosomal protein L40 isoform X2

    See identical proteins and their annotated locations for XP_005260110.1

    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  3. XM_005260052.2XP_005260109.1  ubiquitin-60S ribosomal protein L40 isoform X2

    See identical proteins and their annotated locations for XP_005260109.1

    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  4. XM_006722871.2XP_006722934.1  ubiquitin-60S ribosomal protein L40 isoform X2

    See identical proteins and their annotated locations for XP_006722934.1

    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  5. XM_017027198.1XP_016882687.1  ubiquitin-60S ribosomal protein L40 isoform X1

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