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UBA52 ubiquitin A-52 residue ribosomal protein fusion product 1 [ Homo sapiens (human) ]

Gene ID: 7311, updated on 4-Feb-2024

Summary

Official Symbol
UBA52provided by HGNC
Official Full Name
ubiquitin A-52 residue ribosomal protein fusion product 1provided by HGNC
Primary source
HGNC:HGNC:12458
See related
Ensembl:ENSG00000221983 MIM:191321; AllianceGenome:HGNC:12458
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
L40; CEP52; RPL40; HUBCEP52
Summary
Ubiquitin is a highly conserved nuclear and cytoplasmic protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome. It is also involved in the maintenance of chromatin structure, the regulation of gene expression, and the stress response. Ubiquitin is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin moiety fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein L40 at the C terminus, a C-terminal extension protein (CEP). Multiple processed pseudogenes derived from this gene are present in the genome. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in ovary (RPKM 89.0), bone marrow (RPKM 83.5) and 25 other tissues See more
Orthologs
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Genomic context

See UBA52 in Genome Data Viewer
Location:
19p13.11
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18563766..18577550)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18698806..18712614)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18682534..18688360)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18557131-18557659 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18561006-18561812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18561813-18562619 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:18566359-18566575 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14321 Neighboring gene elongation factor for RNA polymerase II Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18579531-18580168 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10403 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10404 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18587281-18588108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18589364-18590266 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18594428-18594928 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18594929-18595429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18596277-18596862 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18605831-18606730 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14323 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18611236-18612222 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14324 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18618231-18619072 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10405 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18631869-18632384 Neighboring gene OCT4-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18632385-18632900 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14325 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18640318-18641203 Neighboring gene Sharpr-MPRA regulatory region 11651 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18652136-18652636 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10407 Neighboring gene FKBP prolyl isomerase 8 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18667707-18668498 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18668499-18669288 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18672913-18673498 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18682001-18682677 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18683356-18684032 Neighboring gene KxDL motif containing 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18702459-18702982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18703866-18704367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10411 Neighboring gene Sharpr-MPRA regulatory region 11645 Neighboring gene required for excision 1-B domain containing Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18716731-18717649 Neighboring gene cytokine receptor like factor 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag Cellular biotinylated ubiquitin A-52 residue ribosomal protein fusion product 1 protein (UBA52, ubiquitin-60S ribosomal protein L40) is incorporated into HIV-1 Gag virus-like particles PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of ubiquitin A-52 ribosomal protein fusion product 1 (UBA52, RPL40) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC57125, MGC126879, MGC126881

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein tag activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IBA
Inferred from Biological aspect of Ancestor
more info
 
enables structural constituent of ribosome IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
Process Evidence Code Pubs
involved_in cytoplasmic translation IC
Inferred by Curator
more info
PubMed 
involved_in cytoplasmic translation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in modification-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein modification process TAS
Traceable Author Statement
more info
 
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm NAS
Non-traceable Author Statement
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of cytosolic large ribosomal subunit IPI
Inferred from Physical Interaction
more info
PubMed 
located_in cytosolic ribosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of cytosolic small ribosomal subunit IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in endocytic vesicle membrane TAS
Traceable Author Statement
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 
located_in endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
located_in endosome membrane TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in extracellular space HDA PubMed 
located_in lysosomal membrane HDA PubMed 
located_in mitochondrial outer membrane TAS
Traceable Author Statement
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus HDA PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in vesicle HDA PubMed 

General protein information

Preferred Names
ubiquitin-ribosomal protein eL40 fusion protein
Names
ubiquitin carboxyl extension protein 52
ubiquitin-52 amino acid fusion protein
ubiquitin-60S ribosomal protein L40
ubiquitin-CEP52

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_023288.2 RefSeqGene

    Range
    13093..18786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001033930.3NP_001029102.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_001029102.1

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BQ428515, BQ428688, BU677484, CB124676
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
    UniProtKB/TrEMBL
    Q3MIH3
    Related
    ENSP00000388107.1, ENST00000442744.7
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  2. NM_001321017.2NP_001307946.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BQ428515, BU677484, DA949569
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
    UniProtKB/TrEMBL
    Q3MIH3
    Related
    ENSP00000472264.1, ENST00000596304.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  3. NM_001321018.2NP_001307947.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BG035502, BQ428515, BU677484, CD242660
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
    UniProtKB/TrEMBL
    Q3MIH3
    Related
    ENSP00000470419.1, ENST00000595683.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  4. NM_001321019.2NP_001307948.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BG035502, BQ428515, BU677484, CD385706
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
    UniProtKB/TrEMBL
    Q3MIH3
    Related
    ENSP00000471622.1, ENST00000595158.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  5. NM_001321020.2NP_001307949.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BE514609, BG035502, BQ428515, BU677484
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
    UniProtKB/TrEMBL
    Q3MIH3
    Related
    ENSP00000472545.1, ENST00000598780.5
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family
  6. NM_001321021.1NP_001307950.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and initiates translation at an alternate start site, compared to variant 1. It encodes isoform 2, which has a longer N-terminus compared to isoform 1. This isoform (2) may undergo proteolytic processing similar to isoform 1.
    Source sequence(s)
    AC005253, AF545864, BG341101, BQ428515, BU677484
    UniProtKB/TrEMBL
    Q7Z4P3
    Conserved Domains (2) summary
    cd01803
    Location:883
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:86133
    Ribosomal_L40e; Ribosomal L40e family
  7. NM_001321022.2NP_001307951.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 3

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF545864, BG341101, BQ428515, BU677484, HY153317
    UniProtKB/TrEMBL
    Q7Z4P3
    Conserved Domains (2) summary
    pfam01020
    Location:5097
    Ribosomal_L40e; Ribosomal L40e family
    cl28922
    Location:147
    Ubiquitin_like_fold; Beta-grasp ubiquitin-like fold
  8. NM_003333.5NP_003324.1  ubiquitin-ribosomal protein eL40 fusion protein isoform 1 precursor

    See identical proteins and their annotated locations for NP_003324.1

    Status: REVIEWED

    Source sequence(s)
    AC005253, AF348700, AF545864, BQ428515, BQ428688, BU677484
    Consensus CDS
    CCDS12382.1
    UniProtKB/Swiss-Prot
    P02248, P02249, P02250, P14793, P62987, P62988, Q29120, Q6LBL4, Q6LDU5, Q8WYN8, Q91887, Q91888, Q9BWD6, Q9BX98, Q9UEF2, Q9UEG1, Q9UEK8, Q9UPK7
    UniProtKB/TrEMBL
    Q3MIH3
    Related
    ENSP00000396910.1, ENST00000430157.6
    Conserved Domains (2) summary
    cd01803
    Location:176
    Ubl_ubiquitin; ubiquitin-like (Ubl) domain found in ubiquitin
    pfam01020
    Location:79126
    Ribosomal_L40e; Ribosomal L40e family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    18563766..18577550
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005260054.2XP_005260111.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    See identical proteins and their annotated locations for XP_005260111.1

    UniProtKB/TrEMBL
    M0R2S1
    Related
    ENSP00000472768.1, ENST00000596272.5
    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  2. XM_006722871.3XP_006722934.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    See identical proteins and their annotated locations for XP_006722934.1

    UniProtKB/TrEMBL
    M0R2S1
    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  3. XM_005260052.3XP_005260109.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    See identical proteins and their annotated locations for XP_005260109.1

    UniProtKB/TrEMBL
    M0R2S1
    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  4. XM_005260053.4XP_005260110.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    See identical proteins and their annotated locations for XP_005260110.1

    UniProtKB/TrEMBL
    M0R2S1
    Conserved Domains (3) summary
    cd01803
    Location:176
    Ubiquitin; Ubiquitin
    smart00213
    Location:172
    UBQ; Ubiquitin homologues
    pfam01020
    Location:78154
    Ribosomal_L40e; Ribosomal L40e family
  5. XM_017027198.2XP_016882687.2  ubiquitin-ribosomal protein eL40 fusion protein isoform X1

    UniProtKB/TrEMBL
    M0R2S1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    18698806..18712614
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321937.1XP_054177912.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    UniProtKB/TrEMBL
    M0R2S1
  2. XM_054321936.1XP_054177911.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    UniProtKB/TrEMBL
    M0R2S1
  3. XM_054321933.1XP_054177908.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    UniProtKB/TrEMBL
    M0R2S1
  4. XM_054321934.1XP_054177909.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X2

    UniProtKB/TrEMBL
    M0R2S1
  5. XM_054321932.1XP_054177907.1  ubiquitin-ribosomal protein eL40 fusion protein isoform X1

    UniProtKB/TrEMBL
    M0R2S1