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C5AR1 complement C5a receptor 1 [ Homo sapiens (human) ]

Gene ID: 728, updated on 5-Jan-2022

Summary

Official Symbol
C5AR1provided by HGNC
Official Full Name
complement C5a receptor 1provided by HGNC
Primary source
HGNC:HGNC:1338
See related
Ensembl:ENSG00000197405 MIM:113995
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C5A; C5AR; C5R1; CD88
Summary
Enables G protein-coupled receptor activity and complement component C5a receptor activity. Involved in several processes, including complement component C5a signaling pathway; mRNA transcription by RNA polymerase II; and positive regulation of ERK1 and ERK2 cascade. Located in apical part of cell and basolateral plasma membrane. Biomarker of Alzheimer's disease; asthma; chronic obstructive pulmonary disease; rhinitis; and severe acute respiratory syndrome. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in appendix (RPKM 41.3), bone marrow (RPKM 38.2) and 11 other tissues See more
Orthologs
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Genomic context

See C5AR1 in Genome Data Viewer
Location:
19q13.32
Exon count:
3
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (47309861..47322066)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (47813118..47825323)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene CRISPRi-validated cis-regulatory element chr19.5070 Neighboring gene uncharacterized LOC105372427 Neighboring gene Sharpr-MPRA regulatory region 10427 Neighboring gene complement C5a receptor 2 Neighboring gene DExH-box helicase 34

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome wide association scan for chronic periodontitis implicates novel locus.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
HIV-1 infectivity involves C5AR1 in complex with CCR5 on THP-1 and monocyte-derived macrophages as shown through decreased CCR5-tropic provirus genomic integration in the presence of neutralizing C5aR1 antibody or siRNA or hC5a PubMed

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env Interaction of HIV-1 gp120 with CD4 is sufficient to trigger a marked reduction in C5a Receptor and a modest reduction in FMLP Receptor on monocytes PubMed
Nef nef Stable expression of HIV-1 Nef induces the upregulated expression of CD88 (complement receptor C5a) PubMed
Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of complement component 5a receptor 1 (C5AR1) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity IPI
Inferred from Physical Interaction
more info
PubMed 
enables complement component C5a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables complement component C5a receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of phospholipase C activity TAS
Traceable Author Statement
more info
PubMed 
involved_in amyloid-beta clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in astrocyte activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular defense response TAS
Traceable Author Statement
more info
PubMed 
involved_in chemotaxis TAS
Traceable Author Statement
more info
PubMed 
involved_in cognition ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in complement component C5a signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in defense response to Gram-positive bacterium IEA
Inferred from Electronic Annotation
more info
 
involved_in immune response TAS
Traceable Author Statement
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in microglial cell activation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of angiogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of epithelial cell proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of macrophage chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of neutrophil chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of vascular endothelial growth factor production IEA
Inferred from Electronic Annotation
more info
 
involved_in presynapse organization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tau-protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to peptidoglycan IEA
Inferred from Electronic Annotation
more info
 
involved_in sensory perception of chemical stimulus TAS
Traceable Author Statement
more info
PubMed 
involved_in signal transduction TAS
Traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in apical part of cell IDA
Inferred from Direct Assay
more info
PubMed 
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane TAS
Traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 
located_in secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
C5a anaphylatoxin chemotactic receptor 1
Names
C5a anaphylatoxin receptor
C5a ligand
C5a-R
complement component 5a receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001736.4NP_001727.2  C5a anaphylatoxin chemotactic receptor 1

    Status: VALIDATED

    Source sequence(s)
    AC099491
    Consensus CDS
    CCDS33063.1
    Related
    ENSP00000347197.2, ENST00000355085.4
    Conserved Domains (1) summary
    cd15114
    Location:38311
    7tmA_C5aR; complement component 5a anaphylatoxin chemotactic receptors, member of the class A family of seven-transmembrane G protein-coupled receptors

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    47309861..47322066
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005259190.5XP_005259247.1  C5a anaphylatoxin chemotactic receptor 1 isoform X1

    See identical proteins and their annotated locations for XP_005259247.1

    Conserved Domains (1) summary
    pfam00001
    Location:1181
    7tm_1; 7 transmembrane receptor (rhodopsin family)
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