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C5ar1 complement component 5a receptor 1 [ Mus musculus (house mouse) ]

Gene ID: 12273, updated on 2-Oct-2022

Summary

Official Symbol
C5ar1provided by MGI
Official Full Name
complement component 5a receptor 1provided by MGI
Primary source
MGI:MGI:88232
See related
Ensembl:ENSMUSG00000049130 AllianceGenome:MGI:88232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
C5aR; C5r1; Cd88; D7Msu1
Summary
Enables complement component C5a receptor activity. Involved in several processes, including astrocyte activation; positive regulation of vascular endothelial growth factor production; and regulation of granulocyte chemotaxis. Acts upstream of or within defense response to Gram-positive bacterium; neutrophil chemotaxis; and response to peptidoglycan. Predicted to be located in several cellular components, including apical part of cell; basolateral plasma membrane; and cell surface. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; liver; neural ectoderm; and sensory organ. Orthologous to several human genes including OPRPN (opiorphin prepropeptide). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 10.0), mammary gland adult (RPKM 8.9) and 20 other tissues See more
Orthologs
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Genomic context

See C5ar1 in Genome Data Viewer
Location:
7 A2; 7 8.77 cM
Exon count:
3
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (15980668..15993465, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16246743..16259540, complement)

Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene DEAH (Asp-Glu-Ala-His) box polypeptide 34 Neighboring gene predicted gene, 26473 Neighboring gene complement component 5a receptor 2 Neighboring gene InaF motif containing 1 Neighboring gene coiled-coil domain containing 9 Neighboring gene BCL2 binding component 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Targeted (8)  1 citation
  • Endonuclease-mediated (6) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein-coupled receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables G protein-coupled receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables complement component C5a binding ISO
Inferred from Sequence Orthology
more info
 
enables complement component C5a receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables complement component C5a receptor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables complement component C5a receptor activity ISO
Inferred from Sequence Orthology
more info
 
enables complement receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in amyloid-beta clearance IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in astrocyte activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cell proliferation in hindbrain ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in chemotaxis IEA
Inferred from Electronic Annotation
more info
 
involved_in cognition IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in complement component C5a signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in complement receptor mediated signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in inflammatory response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mRNA transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in microglial cell activation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of neuron apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of ERK1 and ERK2 cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cytosolic calcium ion concentration ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of epithelial cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macrophage chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of neutrophil chemotaxis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of vascular endothelial growth factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in presynapse organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of tau-protein kinase activity IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within response to peptidoglycan IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in apical part of cell ISO
Inferred from Sequence Orthology
more info
 
located_in basolateral plasma membrane ISO
Inferred from Sequence Orthology
more info
 
located_in cell surface ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
C5a anaphylatoxin chemotactic receptor 1
Names
C5a anaphylatoxin receptor
C5a ligand
C5a-R
complement component 5, receptor 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001173550.1NP_001167021.1  C5a anaphylatoxin chemotactic receptor 1

    See identical proteins and their annotated locations for NP_001167021.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1.
    Source sequence(s)
    AC156630
    Consensus CDS
    CCDS20846.1
    UniProtKB/Swiss-Prot
    P30993, Q3TZ86
    Related
    ENSMUSP00000129972.2, ENSMUST00000168818.2
    Conserved Domains (1) summary
    pfam00001
    Location:54301
    7tm_1; 7 transmembrane receptor (rhodopsin family)
  2. NM_007577.4NP_031603.2  C5a anaphylatoxin chemotactic receptor 1

    See identical proteins and their annotated locations for NP_031603.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) and variant 2 encode the same protein.
    Source sequence(s)
    AC156630, BB666123, BC125641
    Consensus CDS
    CCDS20846.1
    UniProtKB/Swiss-Prot
    P30993, Q3TZ86
    Related
    ENSMUSP00000060003.6, ENSMUST00000050770.6
    Conserved Domains (1) summary
    pfam00001
    Location:54301
    7tm_1; 7 transmembrane receptor (rhodopsin family)

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000073.7 Reference GRCm39 C57BL/6J

    Range
    15980668..15993465 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)