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DNAJC7 DnaJ heat shock protein family (Hsp40) member C7 [ Homo sapiens (human) ]

Gene ID: 7266, updated on 5-May-2020

Summary

Official Symbol
DNAJC7provided by HGNC
Official Full Name
DnaJ heat shock protein family (Hsp40) member C7provided by HGNC
Primary source
HGNC:HGNC:12392
See related
Ensembl:ENSG00000168259 MIM:601964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
DJ11; DJC7; TPR2; TTC2
Summary
This gene encodes a member of the DNAJ heat shock protein 40 family of proteins that is characterized by two N-terminal tetratricopeptide repeat domains and a C-terminal DNAJ domain. This protein binds the chaperone proteins heat shock proteins 70 and 90 in an ATP-dependent manner and may function as a co-chaperone. Pseudogenes of this gene are found on chromosomes 1 and 6. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Oct 2009]
Expression
Ubiquitous expression in brain (RPKM 25.3), lymph node (RPKM 14.6) and 25 other tissues See more
Orthologs

Genomic context

See DNAJC7 in Genome Data Viewer
Location:
17q21.2
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (41976421..42021371, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40128439..40169715, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATP citrate lyase Neighboring gene tetratricopeptide repeat domain 25 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene NFKB inhibitor interacting Ras like 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 17 open reading frame 113 Neighboring gene DExH-box helicase 58

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif is identified to have a physical interaction with DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol Positional proteomics analysis identifies the cleavage of human DnaJ (Hsp40) homolog, subfamily C, member 7 (DNAJC7) at amino acid residues 11-12 and 435-436 by the HIV-1 protease PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
heat shock protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
chaperone cofactor-dependent protein refolding IDA
Inferred from Direct Assay
more info
PubMed 
protein folding TAS
Traceable Author Statement
more info
PubMed 
regulation of cellular response to heat TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 7
Names
DnaJ (Hsp40) homolog, subfamily C, member 7
TPR repeat protein 2
tetratricopeptide repeat domain 2
tetratricopeptide repeat protein 2

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001144766.2NP_001138238.1  dnaJ homolog subfamily C member 7 isoform 2

    See identical proteins and their annotated locations for NP_001138238.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (2) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AC105024, AC125257, AK298860, BQ445927
    Consensus CDS
    CCDS45678.1
    UniProtKB/Swiss-Prot
    Q99615
    Related
    ENSP00000394327.2, ENST00000426588.7
    Conserved Domains (4) summary
    COG0484
    Location:324413
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:201228
    TPR; TPR repeat [structural motif]
    cl26002
    Location:3302
    TPR_11; TPR repeat
    cl26005
    Location:197297
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. NM_003315.4NP_003306.3  dnaJ homolog subfamily C member 7 isoform 1

    See identical proteins and their annotated locations for NP_003306.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC011837, BQ445927, BX647209
    Consensus CDS
    CCDS45677.1
    UniProtKB/Swiss-Prot
    Q99615
    Related
    ENSP00000406463.2, ENST00000457167.9
    Conserved Domains (4) summary
    COG0484
    Location:380469
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:257284
    TPR; TPR repeat [structural motif]
    cl26002
    Location:35386
    TPR_11; TPR repeat
    cl26005
    Location:253353
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RNA

  1. NR_029431.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AC105024, BC003601, BQ445927

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    41976421..42021371 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525168.3XP_011523470.1  dnaJ homolog subfamily C member 7 isoform X1

    See identical proteins and their annotated locations for XP_011523470.1

    UniProtKB/Swiss-Prot
    Q99615
    Conserved Domains (4) summary
    COG0484
    Location:324413
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:201228
    TPR; TPR repeat [structural motif]
    cl26002
    Location:3302
    TPR_11; TPR repeat
    cl26005
    Location:197297
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  2. XM_011525169.3XP_011523471.1  dnaJ homolog subfamily C member 7 isoform X1

    See identical proteins and their annotated locations for XP_011523471.1

    UniProtKB/Swiss-Prot
    Q99615
    Related
    ENSP00000501364.1, ENST00000674166.1
    Conserved Domains (4) summary
    COG0484
    Location:324413
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:201228
    TPR; TPR repeat [structural motif]
    cl26002
    Location:3302
    TPR_11; TPR repeat
    cl26005
    Location:197297
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  3. XM_017024994.2XP_016880483.1  dnaJ homolog subfamily C member 7 isoform X1

    UniProtKB/Swiss-Prot
    Q99615
    Related
    ENSP00000501366.1, ENST00000674252.1
    Conserved Domains (4) summary
    COG0484
    Location:324413
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:201228
    TPR; TPR repeat [structural motif]
    cl26002
    Location:3302
    TPR_11; TPR repeat
    cl26005
    Location:197297
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
  4. XM_011525167.3XP_011523469.1  dnaJ homolog subfamily C member 7 isoform X1

    See identical proteins and their annotated locations for XP_011523469.1

    UniProtKB/Swiss-Prot
    Q99615
    Related
    ENSP00000313311.7, ENST00000316603.11
    Conserved Domains (4) summary
    COG0484
    Location:324413
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:201228
    TPR; TPR repeat [structural motif]
    cl26002
    Location:3302
    TPR_11; TPR repeat
    cl26005
    Location:197297
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

RNA

  1. XR_001752602.2 RNA Sequence

    Related
    ENST00000586335.2
  2. XR_001752603.2 RNA Sequence

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