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Dnajc7 DnaJ heat shock protein family (Hsp40) member C7 [ Mus musculus (house mouse) ]

Gene ID: 56354, updated on 6-Jun-2024

Summary

Official Symbol
Dnajc7provided by MGI
Official Full Name
DnaJ heat shock protein family (Hsp40) member C7provided by MGI
Primary source
MGI:MGI:1928373
See related
Ensembl:ENSMUSG00000014195 AllianceGenome:MGI:1928373
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CCRP; Ttc2; mDj11; mTpr2; 2010003F24Rik; 2010004G07Rik
Summary
Predicted to enable heat shock protein binding activity. Predicted to be involved in chaperone cofactor-dependent protein refolding. Predicted to be located in cytosol and nucleoplasm. Is expressed in several structures, including alimentary system; brain; cardiovascular system; genitourinary system; and respiratory system. Orthologous to human DNAJC7 (DnaJ heat shock protein family (Hsp40) member C7). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in CNS E11.5 (RPKM 43.0), CNS E14 (RPKM 34.9) and 23 other tissues See more
Orthologs
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Genomic context

See Dnajc7 in Genome Data Viewer
Location:
11 D; 11 63.47 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (100473644..100511030, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (100582818..100620292, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E5277 Neighboring gene outer dynein arm complex subunit 4 Neighboring gene STARR-positive B cell enhancer ABC_E8995 Neighboring gene STARR-positive B cell enhancer ABC_E7060 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:100443371-100443554 Neighboring gene 2',3'-cyclic nucleotide 3' phosphodiesterase Neighboring gene STARR-positive B cell enhancer ABC_E4000 Neighboring gene STARR-positive B cell enhancer ABC_E7061 Neighboring gene STARR-positive B cell enhancer ABC_E2369 Neighboring gene STARR-positive B cell enhancer ABC_E7062 Neighboring gene NFKB inhibitor interacting Ras-like protein 2 Neighboring gene zinc finger protein 385C Neighboring gene chromosome 11 C17orf113 homolog Neighboring gene predicted gene, 38483 Neighboring gene DExH-box helicase 58

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Gene trapped (2) 
  • Targeted (4)  1 citation

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables heat shock protein binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in chaperone cofactor-dependent protein refolding ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
dnaJ homolog subfamily C member 7
Names
DnaJ (Hsp40) homolog, subfamily C, member 7
TPR repeat protein 2
cytoplasmic CAR retention protein
tetratricopeptide repeat domain 2
tetratricopeptide repeat protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001378962.1NP_001365891.1  dnaJ homolog subfamily C member 7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    UniProtKB/TrEMBL
    A0A6I8MX00, A2A5E1
    Related
    ENSMUSP00000115438.3, ENSMUST00000146840.3
    Conserved Domains (4) summary
    PLN03088
    Location:237337
    PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional
    COG0484
    Location:364453
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    TIGR00990
    Location:8337
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:241268
    TPR; TPR repeat [structural motif]
  2. NM_001378963.1NP_001365892.1  dnaJ homolog subfamily C member 7 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AL591469
    UniProtKB/TrEMBL
    A0A6I8MWW2, A0A6I8MX31
    Related
    ENSMUSP00000159367.2, ENSMUST00000154972.9
    Conserved Domains (2) summary
    TIGR00990
    Location:19136
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:2856
    TPR; TPR repeat [structural motif]
  3. NM_001403603.1NP_001390532.1  dnaJ homolog subfamily C member 7 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    UniProtKB/Swiss-Prot
    Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3
    UniProtKB/TrEMBL
    Q3UL32
    Related
    ENSMUSP00000159311.2, ENSMUST00000239410.2
  4. NM_019795.5NP_062769.2  dnaJ homolog subfamily C member 7 isoform 1

    See identical proteins and their annotated locations for NP_062769.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL591469, BX842667
    Consensus CDS
    CCDS25428.1
    UniProtKB/Swiss-Prot
    Q3TKR1, Q6VVW6, Q8BPG3, Q8CIL2, Q9CT29, Q9D026, Q9QYI3
    UniProtKB/TrEMBL
    Q3UL32
    Related
    ENSMUSP00000014339.9, ENSMUST00000014339.15
    Conserved Domains (7) summary
    smart00028
    Location:2861
    TPR; Tetratricopeptide repeats
    COG0484
    Location:380469
    DnaJ; DnaJ-class molecular chaperone with C-terminal Zn finger domain [Posttranslational modification, protein turnover, chaperones]
    sd00006
    Location:257284
    TPR; TPR repeat [structural motif]
    pfam00226
    Location:381448
    DnaJ; DnaJ domain
    pfam00515
    Location:294327
    TPR_1; Tetratricopeptide repeat
    pfam13414
    Location:2792
    TPR_11; TPR repeat
    pfam13431
    Location:5082
    TPR_17; Tetratricopeptide repeat

RNA

  1. NR_166203.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    Related
    ENSMUST00000239418.2
  2. NR_166204.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AL591469, BX842667
    Related
    ENSMUST00000239499.2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    100473644..100511030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036156865.1XP_036012758.1  dnaJ homolog subfamily C member 7 isoform X2

    Conserved Domains (2) summary
    TIGR00990
    Location:104221
    3a0801s09; mitochondrial precursor proteins import receptor (72 kDa mitochondrial outermembrane protein) (mitochondrial import receptor for the ADP/ATP carrier) (translocase of outermembrane tom70)
    sd00006
    Location:113141
    TPR; TPR repeat [structural motif]

RNA

  1. XR_001780034.3 RNA Sequence