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TSNAX translin associated factor X [ Homo sapiens (human) ]

Gene ID: 7257, updated on 7-Jan-2024

Summary

Official Symbol
TSNAXprovided by HGNC
Official Full Name
translin associated factor Xprovided by HGNC
Primary source
HGNC:HGNC:12380
See related
Ensembl:ENSG00000116918 MIM:602964; AllianceGenome:HGNC:12380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3PO; TRAX
Summary
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 19.1), thyroid (RPKM 18.7) and 25 other tissues See more
Orthologs
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Genomic context

See TSNAX in Genome Data Viewer
Location:
1q42.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (231528669..231566524)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (230911903..230949724)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231664415..231702270)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene NANOG hESC enhancer GRCh37_chr1:231614566-231615067 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:231634962-231635134 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene 2 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:231647424-231648623 Neighboring gene uncharacterized LOC122526782 Neighboring gene Sharpr-MPRA regulatory region 8140 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:231663972-231665171 Neighboring gene TSNAX-DISC1 readthrough (NMD candidate) Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2731 Neighboring gene long intergenic non-protein coding RNA 582 Neighboring gene MPRA-validated peak764 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1954 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1955 Neighboring gene MPRA-validated peak765 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231787054-231787554 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:231787555-231788055 Neighboring gene DISC1 scaffold protein Neighboring gene RNA, U5A small nuclear 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables A2A adenosine receptor binding IEA
Inferred from Electronic Annotation
more info
 
enables DNA binding TAS
Traceable Author Statement
more info
PubMed 
enables RNA binding HDA PubMed 
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA endonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulatory ncRNA-mediated post-transcriptional gene silencing NAS
Non-traceable Author Statement
more info
PubMed 
involved_in siRNA processing IDA
Inferred from Direct Assay
more info
PubMed 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
part_of endoribonuclease complex IPI
Inferred from Physical Interaction
more info
PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
translin-associated protein X
Names
translin-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005999.3NP_005990.1  translin-associated protein X

    See identical proteins and their annotated locations for NP_005990.1

    Status: REVIEWED

    Source sequence(s)
    AL445524, AL626763
    Consensus CDS
    CCDS1596.1
    UniProtKB/Swiss-Prot
    B1APC6, Q99598
    Related
    ENSP00000355599.3, ENST00000366639.9
    Conserved Domains (1) summary
    cd14805
    Location:42256
    Translin-like; Translin and translin-associated factor-X (TRAX)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    231528669..231566524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    230911903..230949724
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)