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TSNAX translin associated factor X [ Homo sapiens (human) ]

Gene ID: 7257, updated on 7-Jun-2020

Summary

Official Symbol
TSNAXprovided by HGNC
Official Full Name
translin associated factor Xprovided by HGNC
Primary source
HGNC:HGNC:12380
See related
Ensembl:ENSG00000116918 MIM:602964
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
C3PO; TRAX
Summary
This gene encodes a protein which specifically interacts with translin, a DNA-binding protein that binds consensus sequences at breakpoint junctions of chromosomal translocations. The encoded protein contains bipartite nuclear targeting sequences that may provide nuclear transport for translin, which lacks any nuclear targeting motifs. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in adrenal (RPKM 19.1), thyroid (RPKM 18.7) and 25 other tissues See more
Orthologs

Genomic context

See TSNAX in Genome Data Viewer
Location:
1q42.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (231528669..231566524)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (231664399..231702270)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107985360 Neighboring gene egl-9 family hypoxia inducible factor 1 Neighboring gene small nuclear ribonucleoprotein D2 pseudogene 2 Neighboring gene TSNAX-DISC1 readthrough (NMD candidate) Neighboring gene long intergenic non-protein coding RNA 582 Neighboring gene DISC1 scaffold protein Neighboring gene RNA, U5A small nuclear 5, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
A2A adenosine receptor binding IEA
Inferred from Electronic Annotation
more info
 
DNA binding TAS
Traceable Author Statement
more info
PubMed 
RNA binding HDA PubMed 
endoribonuclease activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex binding IEA
Inferred from Electronic Annotation
more info
 
sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
single-stranded DNA binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
RNA phosphodiester bond hydrolysis, endonucleolytic IEA
Inferred from Electronic Annotation
more info
 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
production of siRNA involved in RNA interference TAS
Traceable Author Statement
more info
 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
translin-associated protein X
Names
translin-like protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005999.3NP_005990.1  translin-associated protein X

    See identical proteins and their annotated locations for NP_005990.1

    Status: REVIEWED

    Source sequence(s)
    AL445524, AL626763
    Consensus CDS
    CCDS1596.1
    UniProtKB/Swiss-Prot
    Q99598
    UniProtKB/TrEMBL
    A0A024R3V8
    Related
    ENSP00000355599.3, ENST00000366639.9
    Conserved Domains (1) summary
    cd14805
    Location:42256
    Translin-like; Translin and translin-associated factor-X (TRAX)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    231528669..231566524
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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