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Sting1 stimulator of interferon response cGAMP interactor 1 [ Mus musculus (house mouse) ]

Gene ID: 72512, updated on 3-Jan-2023

Summary

Official Symbol
Sting1provided by MGI
Official Full Name
stimulator of interferon response cGAMP interactor 1provided by MGI
Primary source
MGI:MGI:1919762
See related
Ensembl:ENSMUSG00000024349 AllianceGenome:MGI:1919762
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
ERIS; MPYS; Mita; STING; Tmem173; STING-beta; 2610307O08Rik
Summary
Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; macroautophagy; and positive regulation of interferon-beta production. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including autophagosome; perinuclear region of cytoplasm; and peroxisome. Is expressed in ductus deferens; epididymis; ileum; and prostate gland. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in spleen adult (RPKM 30.3), mammary gland adult (RPKM 29.1) and 20 other tissues See more
Orthologs
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Genomic context

See Sting1 in Genome Data Viewer
Location:
18 B2; 18
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (35866731..35873607, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (35733678..35740554, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene small integral membrane protein 33 Neighboring gene 40S ribosomal protein S25 pseudogene Neighboring gene ubiquitin-conjugating enzyme E2D 2A

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables 2',3'-cyclic GMP-AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables 2',3'-cyclic GMP-AMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables 2',3'-cyclic GMP-AMP binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables cyclic-di-GMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cyclic-di-GMP binding IDA
Inferred from Direct Assay
more info
PubMed 
enables cyclic-di-GMP binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin protein ligase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in activation of innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in activation of innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in autophagosome assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in autophagosome assembly ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within autophagy IEA
Inferred from Electronic Annotation
more info
 
involved_in cellular response to exogenous dsRNA ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cellular response to interferon-beta IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
involved_in cellular response to organic cyclic compound ISO
Inferred from Sequence Orthology
more info
 
involved_in defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in defense response to virus ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within immune system process IEA
Inferred from Electronic Annotation
more info
 
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in innate immune response ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of defense response to virus by host ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of interferon-beta production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of macroautophagy IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of macroautophagy ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of protein binding ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon production ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of type I interferon-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of type I interferon-mediated signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in protein complex oligomerization ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of cellular metabolic process IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of gene expression IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within regulation of inflammatory response IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in reticulophagy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane ISO
Inferred from Sequence Orthology
more info
 
part_of STING complex IPI
Inferred from Physical Interaction
more info
PubMed 
part_of STING complex ISO
Inferred from Sequence Orthology
more info
 
is_active_in autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in autophagosome ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasmic vesicle IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in endoplasmic reticulum membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endoplasmic reticulum-Golgi intermediate compartment membrane ISO
Inferred from Sequence Orthology
more info
 
located_in endosome ISO
Inferred from Sequence Orthology
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in mitochondrial outer membrane ISO
Inferred from Sequence Orthology
more info
 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in peroxisome IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
stimulator of interferon genes protein
Names
endoplasmic reticulum interferon stimulator
mediator of IRF3 activation
mitochondrial mediator of IRF3 activation
stimulator of interferon protein
transmembrane protein 173

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001289591.1NP_001276520.1  stimulator of interferon genes protein isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate 5' exon and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is longer than isoform 1.
    Source sequence(s)
    AC132837, AK089405, BB871885
    UniProtKB/Swiss-Prot
    Q3TBT3
    Conserved Domains (1) summary
    pfam15009
    Location:93385
    TMEM173; Transmembrane protein 173
  2. NM_001289592.1NP_001276521.1  stimulator of interferon genes protein isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
    Source sequence(s)
    AC132837, AK012006, AK089405, AK158458, BB871885
    Consensus CDS
    CCDS89220.1
    UniProtKB/Swiss-Prot
    Q3TBT3
    Related
    ENSMUSP00000157789.2, ENSMUST00000235495.2
    Conserved Domains (1) summary
    pfam15009
    Location:44295
    TMEM173; Transmembrane protein 173
  3. NM_028261.1NP_082537.1  stimulator of interferon genes protein isoform 1

    See identical proteins and their annotated locations for NP_082537.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
    Source sequence(s)
    AC132837, AK077788, AK089405, AK158458, BB872463
    Consensus CDS
    CCDS50253.1
    UniProtKB/Swiss-Prot
    Q3TBT3, Q9CZY7
    UniProtKB/TrEMBL
    A0A2R3XZC4
    Related
    ENSMUSP00000111393.4, ENSMUST00000115728.5
    Conserved Domains (1) summary
    pfam15009
    Location:44336
    TMEM173; Transmembrane protein 173

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    35866731..35873607 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017317994.3XP_017173483.1  stimulator of interferon genes protein isoform X1

    Conserved Domains (1) summary
    pfam15009
    Location:44345
    TMEM173; Transmembrane protein 173