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STING1 stimulator of interferon response cGAMP interactor 1 [ Homo sapiens (human) ]

Gene ID: 340061, updated on 1-Aug-2020

Summary

Official Symbol
STING1provided by HGNC
Official Full Name
stimulator of interferon response cGAMP interactor 1provided by HGNC
Primary source
HGNC:HGNC:27962
See related
Ensembl:ENSG00000184584 MIM:612374
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; TMEM173; STING-beta
Summary
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues See more
Orthologs

Genomic context

See STING1 in Genome Data Viewer
Location:
5q31.2
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (139475533..139482758, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138855113..138862343, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene small integral membrane protein 33 Neighboring gene cancer-related nucleoside-triphosphatase pseudogene Neighboring gene nuclear receptor coactivator 4 pseudogene 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Sting-associated vasculopathy, infantile-onset
MedGen: C4014722 OMIM: 615934 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr antagonizes TMEM173 (STING)-mediated innate immune recognition in TZM-bl STING cells (TZM-bl cells engineered to express TMEM173 (STING)) PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ38577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclic-GMP-AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclic-GMP-AMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclic-GMP-AMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclic-di-GMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclic-di-GMP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
autophagosome assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome assembly IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interferon-beta IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of macroautophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
protein complex oligomerization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of inflammatory response IEA
Inferred from Electronic Annotation
more info
 
regulation of type I interferon production TAS
Traceable Author Statement
more info
 
reticulophagy IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
reticulophagy ISS
Inferred from Sequence or Structural Similarity
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
autophagosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
autophagosome IDA
Inferred from Direct Assay
more info
PubMed 
autophagosome membrane IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
endosome IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of endoplasmic reticulum-Golgi intermediate compartment (ERGIC) membrane IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
stimulator of interferon genes protein
Names
N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
endoplasmic reticulum IFN stimulator
endoplasmic reticulum interferon stimulator
mitochondrial mediator of IRF3 activation
stimulator of interferon protein
transmembrane protein 173

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034249.1 RefSeqGene

    Range
    5033..12258
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1308

mRNA and Protein(s)

  1. NM_001301738.2NP_001288667.1  stimulator of interferon genes protein isoform 2

    See identical proteins and their annotated locations for NP_001288667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an exon in the 3' coding region, resulting in a frameshift. The encoded isoform (2) has a shorter and distinct C-terminus.
    Source sequence(s)
    AC138517, BI905932, BM708269, BM981219, KF430638
    UniProtKB/TrEMBL
    V5V0K2
    Related
    ENSP00000498513.1, ENST00000652110.1
    Conserved Domains (1) summary
    pfam15009
    Location:44253
    TMEM173; Transmembrane protein 173
  2. NM_001367258.1NP_001354187.1  stimulator of interferon genes protein isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks a coding exon, resulting in a different 5' UTR, and the use of a downstream start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC138517
    Related
    ENSP00000498768.1, ENST00000651565.1
    Conserved Domains (1) summary
    pfam15009
    Location:1218
    TMEM173; Transmembrane protein 173
  3. NM_198282.4NP_938023.1  stimulator of interferon genes protein isoform 1

    See identical proteins and their annotated locations for NP_938023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    BC047779, BI905932, BM981219
    Consensus CDS
    CCDS4215.1
    UniProtKB/Swiss-Prot
    Q86WV6
    Related
    ENSP00000331288.4, ENST00000330794.9
    Conserved Domains (1) summary
    pfam15009
    Location:44337
    TMEM173; Transmembrane protein 173

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    139475533..139482758 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011537639.3XP_011535941.1  stimulator of interferon genes protein isoform X2

    Conserved Domains (1) summary
    pfam15009
    Location:44253
    TMEM173; Transmembrane protein 173

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_021159996.1 Reference GRCh38.p13 PATCHES

    Range
    65328..72553 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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