Format

Send to:

Choose Destination

TMEM173 transmembrane protein 173 [ Homo sapiens (human) ]

Gene ID: 340061, updated on 3-Jun-2018
Official Symbol
TMEM173provided by HGNC
Official Full Name
transmembrane protein 173provided by HGNC
Primary source
HGNC:HGNC:27962
See related
Ensembl:ENSG00000184584 MIM:612374; Vega:OTTHUMG00000129239
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING; STING-beta
Summary
This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Expression
Ubiquitous expression in lung (RPKM 37.4), spleen (RPKM 28.8) and 24 other tissues See more
Orthologs
See TMEM173 in Genome Data Viewer
Location:
5q31.2
Exon count:
9
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 5 NC_000005.10 (139475528..139482790, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138855113..138862343, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene endothelial cell surface expressed chemotaxis and apoptosis regulator Neighboring gene small integral membrane protein 33 Neighboring gene cancer-related nucleoside-triphosphatase pseudogene Neighboring gene nuclear receptor coactivator 4 pseudogene 4

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Associated conditions

Description Tests
Sting-associated vasculopathy, infantile-onset
MedGen: C4014722 OMIM: 615934 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.
NHGRI GWA Catalog
Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Vpr vpr HIV-1 Vpr antagonizes TMEM173 (STING)-mediated innate immune recognition in TZM-bl STING cells (TZM-bl cells engineered to express TMEM173 (STING)) PubMed

Go to the HIV-1, Human Interaction Database

  • Cytosolic DNA-sensing pathway, organism-specific biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Cytosolic DNA-sensing pathway, conserved biosystem (from KEGG)
    Cytosolic DNA-sensing pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting foreign DNA from invading microbes or host cells and generating innate immune responses. DAI is the first identified s...
  • Cytosolic sensors of pathogen-associated DNA, organism-specific biosystem (from REACTOME)
    Cytosolic sensors of pathogen-associated DNA, organism-specific biosystemPresence of pathogen-associated DNA in cytosol induces type I IFN production. Several intracellular receptors have been implicated to some degree. These include DNA-dependent activator of interferon ...
  • IRF3-mediated induction of type I IFN, organism-specific biosystem (from REACTOME)
    IRF3-mediated induction of type I IFN, organism-specific biosystemTANK-binding kinase 1 (TBK1) and interferon regulatory factor 3 (IRF3) are central regulators of type-I interferon induction during bacterial or viral infection. TBK1 was found to form complexes with...
  • Immune System, organism-specific biosystem (from REACTOME)
    Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
  • Innate Immune System, organism-specific biosystem (from REACTOME)
    Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
  • NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
    NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
  • Neutrophil degranulation, organism-specific biosystem (from REACTOME)
    Neutrophil degranulation, organism-specific biosystemNeutrophils are the most abundant leukocytes (white blood cells), indispensable in defending the body against invading microorganisms. In response to infection, neutrophils leave the circulation and ...
  • RIG-I-like Receptor Signaling, organism-specific biosystem (from WikiPathways)
    RIG-I-like Receptor Signaling, organism-specific biosystemViral pathogen RNA are recognized by host helicases called RIG-I-like receptors (RLRs) that include DDX58 (RIG-I), DHX58 (LGP2), IFIH1 (MDA5), SNW1, and DDX17. These RLR proteins then go on to initia...
  • RIG-I-like receptor signaling pathway, organism-specific biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • RIG-I-like receptor signaling pathway, conserved biosystem (from KEGG)
    RIG-I-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting viral pathogens and generating innate immune responses. Non-self RNA appearing in a cell as a result of intracellular ...
  • Regulation of innate immune responses to cytosolic DNA, organism-specific biosystem (from REACTOME)
    Regulation of innate immune responses to cytosolic DNA, organism-specific biosystemInnate immune responses are coordinated and regulated to provide an efficient first line of defense against pathogens and at the same time to prevent host self-damage. Here we present some regulatory...
  • STAT6-mediated induction of chemokines, organism-specific biosystem (from REACTOME)
    STAT6-mediated induction of chemokines, organism-specific biosystemSignal transducer and activator of transcription 6 (STAT6) may function as a signaling molecule and as a transcription factor. The canonical activation of STAT6 in IL4 and IL13 signaling pathways is ...
  • STING mediated induction of host immune responses, organism-specific biosystem (from REACTOME)
    STING mediated induction of host immune responses, organism-specific biosystemSTING (stimulator of IFN genes; also known as MITA/ERIS/MPYS/TMEM173) is an endoplasmic reticulum (ER) resident, which is required for effective type I IFN production in response to nucleic acids. In...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ38577

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cyclic-GMP-AMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclic-GMP-AMP binding IDA
Inferred from Direct Assay
more info
PubMed 
cyclic-GMP-AMP binding ISS
Inferred from Sequence or Structural Similarity
more info
 
cyclic-di-GMP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cyclic-di-GMP binding IDA
Inferred from Direct Assay
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein homodimerization activity IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
activation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to exogenous dsRNA IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cellular response to exogenous dsRNA IMP
Inferred from Mutant Phenotype
more info
PubMed 
cellular response to interferon-beta IEA
Inferred from Electronic Annotation
more info
 
cellular response to organic cyclic compound IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasmic pattern recognition receptor signaling pathway in response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
defense response to virus IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
innate immune response IDA
Inferred from Direct Assay
more info
PubMed 
innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
interferon-beta production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
interferon-beta production IDA
Inferred from Direct Assay
more info
PubMed 
interferon-beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
neutrophil degranulation TAS
Traceable Author Statement
more info
 
positive regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of defense response to virus by host IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of defense response to virus by host IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of protein binding IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type I interferon production IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of type I interferon production IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of type I interferon production TAS
Traceable Author Statement
more info
 
regulation of type I interferon production TAS
Traceable Author Statement
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IEA
Inferred from Electronic Annotation
more info
 
cytoplasmic vesicle membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum membrane TAS
Traceable Author Statement
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
peroxisome IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
 
secretory granule membrane TAS
Traceable Author Statement
more info
 
Preferred Names
stimulator of interferon genes protein
Names
N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner
endoplasmic reticulum IFN stimulator
endoplasmic reticulum interferon stimulator
mitochondrial mediator of IRF3 activation
stimulator of interferon protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034249.1 RefSeqGene

    Range
    5001..12263
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001301738.1NP_001288667.1  stimulator of interferon genes protein isoform 2

    See identical proteins and their annotated locations for NP_001288667.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) has a shorter 5' UTR and lacks an exon in the 3' coding region which results in a frameshift. The encoded isoform (2) has a shorter and distinct C-terminus.
    Source sequence(s)
    AC138517, AK095896, BE548954, BM981219, KF430638
    UniProtKB/TrEMBL
    V5V0K2
    Conserved Domains (1) summary
    pfam15009
    Location:44253
    TMEM173; Transmembrane protein 173
  2. NM_198282.3NP_938023.1  stimulator of interferon genes protein isoform 1

    See identical proteins and their annotated locations for NP_938023.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform 1).
    Source sequence(s)
    AC138517, BC047779, BM981219
    Consensus CDS
    CCDS4215.1
    UniProtKB/Swiss-Prot
    Q86WV6
    Related
    ENSP00000331288.4, OTTHUMP00000159544, ENST00000330794.8, OTTHUMT00000251338
    Conserved Domains (1) summary
    pfam15009
    Location:44337
    TMEM173; Transmembrane protein 173

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p12 Primary Assembly

    Range
    139475528..139482790 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005268445.4XP_005268502.1  stimulator of interferon genes protein isoform X1

    See identical proteins and their annotated locations for XP_005268502.1

    Conserved Domains (1) summary
    pfam15009
    Location:44253
    TMEM173; Transmembrane protein 173
  2. XM_011537640.2XP_011535942.1  stimulator of interferon genes protein isoform X3

    Conserved Domains (1) summary
    pfam15009
    Location:1218
    TMEM173; Transmembrane protein 173
  3. XM_011537639.3XP_011535941.1  stimulator of interferon genes protein isoform X2

    Related
    ENSP00000427455.1, OTTHUMP00000223442, ENST00000510817.1
    Conserved Domains (1) summary
    pfam15009
    Location:44253
    TMEM173; Transmembrane protein 173
Support Center