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Strada STE20-related kinase adaptor alpha [ Mus musculus (house mouse) ]

Gene ID: 72149, updated on 18-Apr-2024

Summary

Official Symbol
Stradaprovided by MGI
Official Full Name
STE20-related kinase adaptor alphaprovided by MGI
Primary source
MGI:MGI:1919399
See related
Ensembl:ENSMUSG00000069631 AllianceGenome:MGI:1919399
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2610019A05Rik; 6030402H20Rik; E130112C09Rik
Summary
Predicted to enable kinase binding activity and protein serine/threonine kinase activator activity. Predicted to contribute to protein serine/threonine kinase activity. Acts upstream of or within activation of protein kinase activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Is expressed in cerebral cortex intermediate zone; cerebral cortex subventricular zone; cerebral cortex ventricular zone; cortical plate; and thymus primordium. Orthologous to human STRADA (STE20 related adaptor alpha). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in testis adult (RPKM 47.7), frontal lobe adult (RPKM 14.7) and 25 other tissues See more
Orthologs
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Genomic context

Location:
11 E1; 11 68.89 cM
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (106053739..106084460, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (106162974..106193634, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene STARR-seq mESC enhancer starr_30916 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106020710-106020950 Neighboring gene predicted gene 10840 Neighboring gene LIM domain containing 2 Neighboring gene STARR-positive B cell enhancer ABC_E7078 Neighboring gene STARR-positive B cell enhancer ABC_E739 Neighboring gene coiled-coil domain containing 47 Neighboring gene STARR-positive B cell enhancer ABC_E5285 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:106078089-106078198 Neighboring gene STARR-positive B cell enhancer ABC_E7080 Neighboring gene DEAD box helicase 42 Neighboring gene STARR-positive B cell enhancer ABC_E5286 Neighboring gene FtsJ RNA 2'-O-methyltransferase 3

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (3)  1 citation
  • Gene trapped (1) 

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein serine/threonine kinase activator activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables protein serine/threonine kinase activator activity ISO
Inferred from Sequence Orthology
more info
 
contributes_to protein serine/threonine kinase activity ISO
Inferred from Sequence Orthology
more info
 
enables protein-containing complex binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_negative_effect G1 to G0 transition ISO
Inferred from Sequence Orthology
more info
 
involved_in activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in activation of protein kinase activity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in protein export from nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein export from nucleus ISO
Inferred from Sequence Orthology
more info
 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
 
part_of intracellular protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 
part_of protein-containing complex ISO
Inferred from Sequence Orthology
more info
 
part_of serine/threonine protein kinase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of serine/threonine protein kinase complex ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
STE20-related kinase adapter protein alpha
Names
STE20-related adapter protein
STRAD alpha
protein kinase LYK5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001252448.2NP_001239377.1  STE20-related kinase adapter protein alpha isoform 1

    See identical proteins and their annotated locations for NP_001239377.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL596331
    Consensus CDS
    CCDS56816.1
    UniProtKB/Swiss-Prot
    Q3UUJ4, Q6VEU7, Q9D0G8
    Related
    ENSMUSP00000007444.8, ENSMUST00000007444.14
    Conserved Domains (1) summary
    cd08227
    Location:70396
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  2. NM_001252449.2NP_001239378.1  STE20-related kinase adapter protein alpha isoform 3

    See identical proteins and their annotated locations for NP_001239378.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks two consecutive exons in the 5' coding region and a segment in the 3' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (3) lacks a segment in the N-terminal region and a segment in the C-terminal region, compared to isoform 1.
    Source sequence(s)
    AL596331
    UniProtKB/Swiss-Prot
    Q3UUJ4
    Conserved Domains (2) summary
    smart00220
    Location:32334
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:33347
    PKc_like; Protein Kinases, catalytic domain
  3. NM_028126.4NP_082402.1  STE20-related kinase adapter protein alpha isoform 2

    See identical proteins and their annotated locations for NP_082402.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks two consecutive exons in the 5' coding region, compared to variant 1. The reading frame is not affected and the resulting isoform (2) lacks an internal segment, compared to isoform 1.
    Source sequence(s)
    AL596331
    Consensus CDS
    CCDS25550.1
    UniProtKB/Swiss-Prot
    Q3UUJ4
    Related
    ENSMUSP00000099361.4, ENSMUST00000103072.10
    Conserved Domains (1) summary
    cd08227
    Location:33359
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    106053739..106084460 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006534293.4XP_006534356.1  STE20-related kinase adapter protein alpha isoform X2

    Conserved Domains (1) summary
    cd08227
    Location:62388
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  2. XM_011249270.1XP_011247572.1  STE20-related kinase adapter protein alpha isoform X1

    See identical proteins and their annotated locations for XP_011247572.1

    UniProtKB/Swiss-Prot
    Q3UUJ4, Q6VEU7, Q9D0G8
    Related
    ENSMUST00000122989.2
    Conserved Domains (1) summary
    cd08227
    Location:70396
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  3. XM_006534294.5XP_006534357.1  STE20-related kinase adapter protein alpha isoform X3

    Conserved Domains (1) summary
    cd08227
    Location:41367
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  4. XM_006534297.5XP_006534360.1  STE20-related kinase adapter protein alpha isoform X5

    See identical proteins and their annotated locations for XP_006534360.1

    Conserved Domains (1) summary
    cd08227
    Location:13339
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  5. XM_006534296.5XP_006534359.1  STE20-related kinase adapter protein alpha isoform X5

    See identical proteins and their annotated locations for XP_006534359.1

    Conserved Domains (1) summary
    cd08227
    Location:13339
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  6. XM_006534295.3XP_006534358.1  STE20-related kinase adapter protein alpha isoform X4

    See identical proteins and their annotated locations for XP_006534358.1

    UniProtKB/Swiss-Prot
    Q3UUJ4
    Conserved Domains (1) summary
    cd08227
    Location:33359
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  7. XM_030246360.2XP_030102220.1  STE20-related kinase adapter protein alpha isoform X3

    Conserved Domains (1) summary
    cd08227
    Location:41367
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha