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STRADA STE20 related adaptor alpha [ Homo sapiens (human) ]

Gene ID: 92335, updated on 7-Dec-2018

Summary

Official Symbol
STRADAprovided by HGNC
Official Full Name
STE20 related adaptor alphaprovided by HGNC
Primary source
HGNC:HGNC:30172
See related
Ensembl:ENSG00000266173 MIM:608626
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LYK5; PMSE; Stlk; STRAD; NY-BR-96; STRAD alpha
Summary
The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009]
Expression
Broad expression in testis (RPKM 18.6), brain (RPKM 8.0) and 24 other tissues See more
Orthologs

Genomic context

See STRADA in Genome Data Viewer
Location:
17q23.3
Exon count:
14
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 17 NC_000017.11 (63702832..63741970, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61780192..61819330, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene mitogen-activated protein kinase kinase kinase 3 Neighboring gene uncharacterized LOC101927898 Neighboring gene uncharacterized LOC729683 Neighboring gene LIM domain containing 2 Neighboring gene coiled-coil domain containing 47 Neighboring gene DEAD-box helicase 42

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Polyhydramnios, megalencephaly, and symptomatic epilepsy
MedGen: C1970203 OMIM: 611087 GeneReviews: Not available
Compare labs

NHGRI GWAS Catalog

Description
Many sequence variants affecting diversity of adult human height.
NHGRI GWA Catalog

Pathways from BioSystems

  • AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystem (from WikiPathways)
    AMP-activated Protein Kinase (AMPK) Signaling, organism-specific biosystemAMPK signaling pathway, a fuel sensor and regulator, promotes ATP-producing and inhibits ATP-consuming pathways in various tissues. AMPK is a heterotrimer composed of alpha-catalytic and beta and gam...
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystem (from REACTOME)
    Energy dependent regulation of mTOR by LKB1-AMPK, organism-specific biosystemUpon formation of a trimeric LKB1:STRAD:MO25 complex, LKB1 phosphorylates and activates AMPK. This phosphorylation is immediately removed in basal conditions by PP2C, but if the cellular AMP:ATP rati...
  • IGF1R signaling cascade, organism-specific biosystem (from REACTOME)
    IGF1R signaling cascade, organism-specific biosystemAfter autophosphorylation the type 1 insulin-like growth factor receptor (IGF1R) binds and phosphorylates scaffold proteins, IRS1/2/4 and SHC1, which in turn bind effectors possessing enzymatic activ...
  • IRS-mediated signalling, organism-specific biosystem (from REACTOME)
    IRS-mediated signalling, organism-specific biosystemRelease of phospho-IRS from the insulin receptor triggers a cascade of signalling events via PI3K, SOS, RAF and the MAP kinases.
  • IRS-related events triggered by IGF1R, organism-specific biosystem (from REACTOME)
    IRS-related events triggered by IGF1R, organism-specific biosystemThe phosphorylated type 1 insulin-like growth factor receptor phosphorylates IR1, IRS2, IRS4 and possibly other IRS/DOK family members (reviewed in Pavelic et al. 2007, Chitnis et al. 2008, Maki et a...
  • Insulin receptor signalling cascade, organism-specific biosystem (from REACTOME)
    Insulin receptor signalling cascade, organism-specific biosystemAutophosphorylation of the insulin receptor triggers a series of signalling events, mediated by SHC or IRS, and resulting in activation of the Ras/RAF and MAP kinase cascades. A second effect of the ...
  • LKB1 signaling events, organism-specific biosystem (from Pathway Interaction Database)
    LKB1 signaling events, organism-specific biosystem
    LKB1 signaling events
  • PI3K Cascade, organism-specific biosystem (from REACTOME)
    PI3K Cascade, organism-specific biosystem
    PI3K Cascade
  • PKB-mediated events, organism-specific biosystem (from REACTOME)
    PKB-mediated events, organism-specific biosystemPKB and PDK1 are activated via membrane-bound PIP3. Activated PDK1 phosphorylates PKB, which in turn phosphorylates PDE3B. The latter hydrolyses cAMP to 5'AMP, depleting cAMP pools.
  • Signal Transduction, organism-specific biosystem (from REACTOME)
    Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
  • Signaling by Insulin receptor, organism-specific biosystem (from REACTOME)
    Signaling by Insulin receptor, organism-specific biosystemInsulin binding to its receptor results in receptor autophosphorylation on tyrosine residues and the tyrosine phosphorylation of insulin receptor substrates (e.g. IRS and Shc) by the insulin receptor...
  • Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystem (from REACTOME)
    Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R), organism-specific biosystemBinding of IGF1 (IGF-I) or IGF2 (IGF-II) to the extracellular alpha peptides of the type 1 insulin-like growth factor receptor (IGF1R) triggers the activation of two major signaling pathways: the SOS...
  • mTOR signaling pathway, organism-specific biosystem (from KEGG)
    mTOR signaling pathway, organism-specific biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signaling pathway, conserved biosystem (from KEGG)
    mTOR signaling pathway, conserved biosystemThe mammalian (mechanistic) target of rapamycin (mTOR) is a highly conserved serine/threonine protein kinase, which exists in two complexes termed mTOR complex 1 (mTORC1) and 2 (mTORC2). mTORC1 conta...
  • mTOR signalling, organism-specific biosystem (from REACTOME)
    mTOR signalling, organism-specific biosystemTarget of rapamycin (mTOR) is a highly-conserved serine/threonine kinase that regulates cell growth and division in response to energy levels, growth signals, and nutrients (Zoncu et al. 2011). Contr...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
activation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
 
protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
NOT protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction by protein phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
stress-activated protein kinase signaling cascade IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
STE20-related kinase adapter protein alpha
Names
STE20-like pseudokinase
STE20-related kinase adaptor alpha
protein kinase LYK5
serologically defined breast cancer antigen NY-BR-96

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_015817.1 RefSeqGene

    Range
    4985..44139
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001003786.3NP_001003786.1  STE20-related kinase adapter protein alpha isoform 2

    See identical proteins and their annotated locations for NP_001003786.1

    Status: REVIEWED

    Source sequence(s)
    AK074771, AY290821, BC043641, BQ682133, DA049174
    Consensus CDS
    CCDS86632.1
    UniProtKB/Swiss-Prot
    Q7RTN6
    UniProtKB/TrEMBL
    Q86YC8
    Related
    ENSP00000492578.1, ENST00000639835.1
    Conserved Domains (2) summary
    cd08227
    Location:33359
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    smart00220
    Location:32342
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  2. NM_001003787.4NP_001003787.1  STE20-related kinase adapter protein alpha isoform 1

    See identical proteins and their annotated locations for NP_001003787.1

    Status: REVIEWED

    Source sequence(s)
    AL832407, AY290821, BK001542, BQ682133
    Consensus CDS
    CCDS32703.1
    UniProtKB/Swiss-Prot
    Q7RTN6
    Related
    ENSP00000336655.6, ENST00000336174.11
    Conserved Domains (2) summary
    cd08227
    Location:70396
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    smart00220
    Location:69379
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  3. NM_001003788.3NP_001003788.1  STE20-related kinase adapter protein alpha isoform 4

    See identical proteins and their annotated locations for NP_001003788.1

    Status: REVIEWED

    Source sequence(s)
    AL832407, AY290821, BK001542, BQ682133, DA049174
    Consensus CDS
    CCDS42367.1
    UniProtKB/Swiss-Prot
    Q7RTN6
    Related
    ENSP00000365000.4, ENST00000375840.9
    Conserved Domains (2) summary
    cd08227
    Location:12338
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    smart00220
    Location:11321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. NM_001165969.2NP_001159441.1  STE20-related kinase adapter protein alpha isoform 5

    See identical proteins and their annotated locations for NP_001159441.1

    Status: REVIEWED

    Source sequence(s)
    AK301331, AL832407, AY290821, BQ682133, DA049174
    Consensus CDS
    CCDS58585.1
    UniProtKB/Swiss-Prot
    Q7RTN6
    Related
    ENSP00000462922.1, ENST00000582137.6
    Conserved Domains (2) summary
    smart00220
    Location:40279
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:41312
    PKc_like; Protein Kinases, catalytic domain
  5. NM_001165970.2NP_001159442.1  STE20-related kinase adapter protein alpha isoform 6

    See identical proteins and their annotated locations for NP_001159442.1

    Status: REVIEWED

    Source sequence(s)
    AK293160, AL832407, AY290821, BQ682133, DA049174
    Consensus CDS
    CCDS54156.1
    UniProtKB/Swiss-Prot
    Q7RTN6
    Related
    ENSP00000398841.3, ENST00000447001.8
    Conserved Domains (2) summary
    smart00220
    Location:40264
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:32297
    PKc_like; Protein Kinases, catalytic domain
  6. NM_001363786.1NP_001350715.1  STE20-related kinase adapter protein alpha isoform 7

    Status: REVIEWED

    Source sequence(s)
    AC015651, AC046185
    Conserved Domains (1) summary
    cd08227
    Location:62388
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  7. NM_001363787.1NP_001350716.1  STE20-related kinase adapter protein alpha isoform 8

    Status: REVIEWED

    Source sequence(s)
    AC015651, AC046185
    Consensus CDS
    CCDS86626.1
    Conserved Domains (1) summary
    cd08227
    Location:41367
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  8. NM_001363788.1NP_001350717.1  STE20-related kinase adapter protein alpha isoform 9

    Status: REVIEWED

    Source sequence(s)
    AC015651, AC046185
    Consensus CDS
    CCDS86630.1
    Conserved Domains (1) summary
    cl21453
    Location:70341
    PKc_like; Protein Kinases, catalytic domain
  9. NM_001363789.1NP_001350718.1  STE20-related kinase adapter protein alpha isoform 10

    Status: REVIEWED

    Source sequence(s)
    AC015651, AC046185
    Consensus CDS
    CCDS86633.1
    Conserved Domains (1) summary
    cl21453
    Location:33304
    PKc_like; Protein Kinases, catalytic domain
  10. NM_001363790.1NP_001350719.1  STE20-related kinase adapter protein alpha isoform 11

    Status: REVIEWED

    Source sequence(s)
    AC015651, AC046185
  11. NM_001363791.1NP_001350720.1  STE20-related kinase adapter protein alpha isoform 12

    Status: REVIEWED

    Source sequence(s)
    AC015651, AC046185
    Consensus CDS
    CCDS86625.1
    Conserved Domains (1) summary
    cl21453
    Location:12283
    PKc_like; Protein Kinases, catalytic domain
  12. NM_153335.6NP_699166.2  STE20-related kinase adapter protein alpha isoform 3

    See identical proteins and their annotated locations for NP_699166.2

    Status: REVIEWED

    Source sequence(s)
    AY290821, BQ682133, DA049174
    Consensus CDS
    CCDS11642.1
    UniProtKB/Swiss-Prot
    Q7RTN6
    Related
    ENSP00000376677.4, ENST00000392950.9
    Conserved Domains (2) summary
    smart00220
    Location:32331
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:33330
    PKc_like; Protein Kinases, catalytic domain

RNA

  1. NR_156741.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC015651, AC046185

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p12 Primary Assembly

    Range
    63702832..63741970 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011525466.3XP_011523768.1  STE20-related kinase adapter protein alpha isoform X2

    UniProtKB/TrEMBL
    A0A1W2PQF1
    Related
    ENSP00000491928.1, ENST00000638193.1
    Conserved Domains (2) summary
    smart00220
    Location:69367
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70369
    PKc_like; Protein Kinases, catalytic domain
  2. XM_017025312.2XP_016880801.1  STE20-related kinase adapter protein alpha isoform X7

    UniProtKB/TrEMBL
    A0A1W2PR00
    Related
    ENSP00000492238.1, ENST00000640086.1
    Conserved Domains (1) summary
    cl21453
    Location:33304
    PKc_like; Protein Kinases, catalytic domain
  3. XM_005257799.3XP_005257856.1  STE20-related kinase adapter protein alpha isoform X5

    See identical proteins and their annotated locations for XP_005257856.1

    UniProtKB/Swiss-Prot
    Q7RTN6
    Related
    ENSP00000491017.1, ENST00000638702.1
    Conserved Domains (2) summary
    cd08227
    Location:12338
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    smart00220
    Location:11321
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  4. XM_011525467.3XP_011523769.1  STE20-related kinase adapter protein alpha isoform X4

    Conserved Domains (2) summary
    cd08227
    Location:35361
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
    smart00220
    Location:34344
    S_TKc; Serine/Threonine protein kinases, catalytic domain
  5. XM_005257797.3XP_005257854.1  STE20-related kinase adapter protein alpha isoform X1

    Conserved Domains (1) summary
    cd08227
    Location:62388
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  6. XM_017025313.1XP_016880802.1  STE20-related kinase adapter protein alpha isoform X9

    UniProtKB/TrEMBL
    A0A1W2PQE8
    Related
    ENSP00000491922.1, ENST00000638276.1
    Conserved Domains (1) summary
    cl21453
    Location:12283
    PKc_like; Protein Kinases, catalytic domain
  7. XM_005257800.3XP_005257857.1  STE20-related kinase adapter protein alpha isoform X6

    UniProtKB/TrEMBL
    A0A1W2PPG2
    Related
    ENSP00000491528.1, ENST00000638888.1
    Conserved Domains (1) summary
    cl21453
    Location:70341
    PKc_like; Protein Kinases, catalytic domain
  8. XM_005257798.3XP_005257855.1  STE20-related kinase adapter protein alpha isoform X3

    UniProtKB/TrEMBL
    A0A1W2PPJ9
    Related
    ENSP00000491580.1, ENST00000638708.1
    Conserved Domains (1) summary
    cd08227
    Location:41367
    PK_STRAD_alpha; Pseudokinase domain of STE20-related kinase adapter protein alpha
  9. XM_005257803.5XP_005257860.1  STE20-related kinase adapter protein alpha isoform X11

    UniProtKB/TrEMBL
    J3QQS3
    Related
    ENSP00000463872.2, ENST00000578801.6
    Conserved Domains (1) summary
    cl21453
    Location:70194
    PKc_like; Protein Kinases, catalytic domain
  10. XM_005257801.5XP_005257858.1  STE20-related kinase adapter protein alpha isoform X8

    UniProtKB/TrEMBL
    A0A1W2PS04
    Related
    ENSP00000492877.1, ENST00000638309.1
    Conserved Domains (2) summary
    smart00220
    Location:69282
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cl21453
    Location:70286
    PKc_like; Protein Kinases, catalytic domain
  11. XM_017025314.2XP_016880803.1  STE20-related kinase adapter protein alpha isoform X10

    UniProtKB/TrEMBL
    J3QS66
    Related
    ENSP00000464547.2, ENST00000578008.6

RNA

  1. XR_243688.3 RNA Sequence

  2. XR_243687.3 RNA Sequence

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