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Suds3 suppressor of defective silencing 3 homolog (S. cerevisiae) [ Mus musculus (house mouse) ]

Gene ID: 71954, updated on 2-Nov-2024

Summary

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Official Symbol
Suds3provided by MGI
Official Full Name
suppressor of defective silencing 3 homolog (S. cerevisiae)provided by MGI
Primary source
MGI:MGI:1919204
See related
Ensembl:ENSMUSG00000066900 AllianceGenome:MGI:1919204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mSds3; 2400003N08Rik; 2410008L21Rik
Summary
Enables histone deacetylase binding activity and identical protein binding activity. Involved in negative regulation of DNA-templated transcription. Acts upstream of or within blastocyst hatching. Part of Sin3-type complex. Is expressed in early conceptus; ovary; secondary oocyte; and seminiferous cord. Orthologous to human SUDS3 (SDS3 homolog, SIN3A corepressor complex component). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in colon adult (RPKM 43.8), ovary adult (RPKM 42.1) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Suds3 in Genome Data Viewer
Location:
5 F; 5 56.88 cM
Exon count:
13
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (117229743..117257980, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (117091678..117115993, complement)

Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene 7478 Neighboring gene predicted gene, 42011 Neighboring gene STARR-positive B cell enhancer ABC_E3606 Neighboring gene STARR-positive B cell enhancer ABC_E2172 Neighboring gene STARR-seq mESC enhancer starr_14168 Neighboring gene STARR-positive B cell enhancer ABC_E6369 Neighboring gene TAO kinase 3 Neighboring gene STARR-positive B cell enhancer ABC_E3607 Neighboring gene STARR-positive B cell enhancer ABC_E3608 Neighboring gene STARR-positive B cell enhancer ABC_E3609 Neighboring gene STARR-seq mESC enhancer starr_14169 Neighboring gene STARR-positive B cell enhancer ABC_E8074 Neighboring gene phosphatidylethanolamine binding protein 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway. Shen J, et al. Inflamm Res, 2024 Sep. PMID 39008037, Free PMC Article
  2. Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53. David G, et al. Oncogene, 2006 Nov 30. PMID 16767157
  3. mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells. David G, et al. Genes Dev, 2003 Oct 1. PMID 14522945, Free PMC Article
  4. Depletion of Suds3 reveals an essential role in early lineage specification. Zhang K, et al. Dev Biol, 2013 Jan 15. PMID 23123966
  5. Cdk5 phosphorylates a component of the HDAC complex and regulates histone acetylation during neuronal cell death. Fu AK, et al. Neurosignals, 2013. PMID 22398430

See all (32) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway.
    Title: SDS3 regulates microglial inflammation by modulating the expression of the upstream kinase ASK1 in the p38 MAPK signaling pathway.
  2. These data define a role for Suds3 in activation of FGF4/ERK signaling.
    Title: Depletion of Suds3 reveals an essential role in early lineage specification.
  3. the identification of Sds3 (suppressor of defective silencing 3) as an adaptor protein that recruits the Sin3 [SWI (switch)-independent 3]-HDAC (histone deacetylase) repression complex and binds Foxk1.
    Title: Foxk1 recruits the Sds3 complex and represses gene expression in myogenic progenitors.
  4. capacity of mSds3 to cooperate with p53 deficiency in cancer predisposition relates to its specific role in chromosome segregation, rather than its central role in maintaining a functional mSin3A complex
    Title: Haploinsufficiency of the mSds3 chromatin regulator promotes chromosomal instability and cancer only upon complete neutralization of p53.
  5. mSds3 and its associated mSin3/HDAC components play a central role in initiating the cascade of pericentric heterochromatin-specific modifications necessary for the proper distribution of chromosomes during cell division in mammalian cells.
    Title: mSin3-associated protein, mSds3, is essential for pericentric heterochromatin formation and chromosome segregation in mammalian cells.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables enzyme binding ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone deacetylase activity ISO
Inferred from Sequence Orthology
more info
  
contributes_to histone deacetylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables histone deacetylase binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within blastocyst hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in chromatin remodeling ISO
Inferred from Sequence Orthology
more info
  
involved_in chromatin remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of cell migration NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
involved_in negative regulation of transcription by RNA polymerase II NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transforming growth factor beta receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in positive regulation of stem cell population maintenance NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
part_of Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of Sin3-type complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of Sin3-type complex NAS
Non-traceable Author Statement
more info
 PubMed 
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in nuclear body ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in nucleus NAS
Non-traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
sin3 histone deacetylase corepressor complex component SDS3
Names
suppressor of defective silencing 3 protein homolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001122666.2 → NP_001116138.1  sin3 histone deacetylase corepressor complex component SDS3 isoform b

    See identical proteins and their annotated locations for NP_001116138.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) represents the shorter transcript and encodes the longer isoform (b).
    Source sequence(s)
    AV338433, BC055764, BC062176, CJ094124
    Consensus CDS
    CCDS51631.1
    UniProtKB/TrEMBL
    A0A0R4J243
    Related
    ENSMUSP00000130535.2, ENSMUST00000166397.3
    Conserved Domains (1) summary
    pfam08598
    Location:62 → 178
    Sds3; Sds3-like

  2. NM_178622.5 → NP_848737.3  sin3 histone deacetylase corepressor complex component SDS3 isoform a

    See identical proteins and their annotated locations for NP_848737.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 3' coding region and the 3' UTR, compared to variant 2. It encodes isoform a, which has a shorter and distinct C-terminus, compared to isoform b.
    Source sequence(s)
    AV338433, BC055764, CJ094124
    Consensus CDS
    CCDS39232.1
    UniProtKB/Swiss-Prot
    Q3UC92, Q6P6K1, Q7TNT0, Q8BR65, Q8BRR7, Q8K5B4
    Related
    ENSMUSP00000083662.6, ENSMUST00000086471.12
    Conserved Domains (1) summary
    pfam08598
    Location:62 → 178
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000071.7 Reference GRCm39 C57BL/6J

    Range
    117229743..117257980 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036165504.1 → XP_036021397.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8BR65.1 GenPept UniProtKB/Swiss-Prot:Q8BR65

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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