Format

Send to:

Choose Destination

SUDS3 SDS3 homolog, SIN3A corepressor complex component [ Homo sapiens (human) ]

Gene ID: 64426, updated on 1-Jun-2020

Summary

Official Symbol
SUDS3provided by HGNC
Official Full Name
SDS3 homolog, SIN3A corepressor complex componentprovided by HGNC
Primary source
HGNC:HGNC:29545
See related
Ensembl:ENSG00000111707 MIM:608250
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SDS3; SAP45
Summary
SDS3 is a subunit of the histone deacetylase (see HDAC1; MIM 601241)-dependent SIN3A (MIM 607776) corepressor complex (Fleischer et al., 2003 [PubMed 12724404]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in thyroid (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues See more
Orthologs

Genomic context

See SUDS3 in Genome Data Viewer
Location:
12q24.23
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 12 NC_000012.12 (118373189..118418033)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (118814358..118855840)

Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene phosphatidylethanolamine binding protein 1 Neighboring gene TAO kinase 3 Neighboring gene ribosomal protein S2 pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 1346 Neighboring gene long intergenic non-protein coding RNA 2460 Neighboring gene ribosomal protein L17 pseudogene 37

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.
NHGRI GWA Catalog
TAOK3, a novel genome-wide association study locus associated with morphine requirement and postoperative pain in a retrospective pediatric day surgery population.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ00052, MGC104711

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
contributes_to histone deacetylase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to histone deacetylase activity IDA
Inferred from Direct Assay
more info
PubMed 
histone deacetylase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylase binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
histone deacetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone deacetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
positive regulation of apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein deubiquitination TAS
Traceable Author Statement
more info
 
substantia nigra development HEP PubMed 
Component Evidence Code Pubs
Sin3 complex ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Sin3-type complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear body IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
sin3 histone deacetylase corepressor complex component SDS3
Names
45 kDa Sin3-associated polypeptide
sin3A-associated protein, 45kDa
suppressor of defective silencing 3 protein homolog

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_022491.3NP_071936.2  sin3 histone deacetylase corepressor complex component SDS3

    See identical proteins and their annotated locations for NP_071936.2

    Status: VALIDATED

    Source sequence(s)
    AA916093, AC026367, AK024460, BC098404
    Consensus CDS
    CCDS44993.1
    UniProtKB/Swiss-Prot
    Q9H7L9
    Related
    ENSP00000443988.1, ENST00000543473.2
    Conserved Domains (1) summary
    pfam08598
    Location:62178
    Sds3; Sds3-like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000012.12 Reference GRCh38.p13 Primary Assembly

    Range
    118373189..118418033
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011538671.2XP_011536973.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X1

    See identical proteins and their annotated locations for XP_011536973.1

    Conserved Domains (1) summary
    pfam08598
    Location:141257
    Sds3; Sds3-like
  2. XM_017019818.1XP_016875307.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X3

  3. XM_017019819.1XP_016875308.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X3

  4. XM_017019820.1XP_016875309.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X4

    Conserved Domains (1) summary
    pfam08598
    Location:1982
    Sds3; Sds3-like
  5. XM_017019817.1XP_016875306.1  sin3 histone deacetylase corepressor complex component SDS3 isoform X2

RNA

  1. XR_944677.2 RNA Sequence

Support Center