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TPT1 tumor protein, translationally-controlled 1 [ Homo sapiens (human) ]

Gene ID: 7178, updated on 13-Jan-2019

Summary

Official Symbol
TPT1provided by HGNC
Official Full Name
tumor protein, translationally-controlled 1provided by HGNC
Primary source
HGNC:HGNC:12022
See related
Ensembl:ENSG00000133112 MIM:600763
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HRF; p02; p23; TCTP
Summary
This gene encodes a protein that is a regulator of cellular growth and proliferation. Its mRNA is highly structured and contains an oligopyrimidine tract (5'-TOP) in its 5' untranslated region that functions to repress its translation under quiescent conditions. The encoded protein is involved in a variety of cellular pathways, including apoptosis, protein synthesis and cell division. It binds to and stabilizes microtubules, and removal of this protein through phosphorylation is required for progression through mitotic and meiotic cell divisions. This gene is known to play a role in carcinogenesis, and is upregulated in some cancer cells. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Expression
Ubiquitous expression in ovary (RPKM 496.6), thyroid (RPKM 416.5) and 25 other tissues See more
Orthologs

Genomic context

See TPT1 in Genome Data Viewer
Location:
13q14.13
Exon count:
6
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (45333471..45341284, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (45911005..45915505, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene general transcription factor IIF subunit 2 Neighboring gene potassium channel tetramerization domain containing 4 Neighboring gene uncharacterized LOC105370190 Neighboring gene small nucleolar RNA, H/ACA box 31B Neighboring gene TPT1 antisense RNA 1 Neighboring gene small nucleolar RNA, H/ACA box 31 Neighboring gene solute carrier family 25 member 30 Neighboring gene reticulocalbin 1 pseudogene 2 Neighboring gene SLC25A30 antisense RNA 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of tumor protein, translationally-controlled 1 (TPT1) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27337

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
calcium ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
calcium ion binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytoplasm TAS
Traceable Author Statement
more info
PubMed 
cytoplasmic microtubule IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
multivesicular body IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
spindle pole IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
translationally-controlled tumor protein
Names
fortilin
histamine-releasing factor

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286272.1NP_001273201.1  translationally-controlled tumor protein isoform 1

    See identical proteins and their annotated locations for NP_001273201.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL138963
    Consensus CDS
    CCDS73566.1
    UniProtKB/TrEMBL
    A0A0B4J2C3
    Related
    ENSP00000477781.1, ENST00000616577.4
    Conserved Domains (1) summary
    pfam00838
    Location:1167
    TCTP; Translationally controlled tumor protein
  2. NM_001286273.1NP_001273202.1  translationally-controlled tumor protein isoform 3

    See identical proteins and their annotated locations for NP_001273202.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) contains multiple differences in the coding region, compared to variant 1, including initiation of translation at a downstream in-frame start codon. The encoded isoform (3) has shorter N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AL138963, BC022436, BP215975
    Consensus CDS
    CCDS66538.1
    UniProtKB/Swiss-Prot
    P13693
    UniProtKB/TrEMBL
    A0A024RDY2
    Related
    ENSP00000368345.1, ENST00000379056.5
    Conserved Domains (1) summary
    pfam00838
    Location:1133
    TCTP; Translationally controlled tumor protein
  3. NM_003295.3NP_003286.1  translationally-controlled tumor protein isoform 2

    See identical proteins and their annotated locations for NP_003286.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) has a shorter C-terminus than isoform 1.
    Source sequence(s)
    AL138963, BP215975, X16064
    Consensus CDS
    CCDS9397.1
    UniProtKB/Swiss-Prot
    P13693
    UniProtKB/TrEMBL
    A0A0P1J1R0
    Related
    ENSP00000431872.1, ENST00000530705.5
    Conserved Domains (1) summary
    pfam00838
    Location:1167
    TCTP; Translationally controlled tumor protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    45333471..45341284 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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