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Stk11ip serine/threonine kinase 11 interacting protein [ Mus musculus (house mouse) ]

Gene ID: 71728, updated on 2-Nov-2024

Summary

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Official Symbol
Stk11ipprovided by MGI
Official Full Name
serine/threonine kinase 11 interacting proteinprovided by MGI
Primary source
MGI:MGI:1918978
See related
Ensembl:ENSMUSG00000026213 AllianceGenome:MGI:1918978
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
LIP1; LKB1IP; 1200014D22Rik
Summary
Predicted to enable protein kinase binding activity. Predicted to be involved in protein localization. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in cytoplasm. Orthologous to human STK11IP (serine/threonine kinase 11 interacting protein). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in ovary adult (RPKM 15.1), spleen adult (RPKM 15.0) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Stk11ip in Genome Data Viewer
Location:
1 C4; 1 39.16 cM
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (75498173..75513979)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (75521529..75537335)

Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene obscurin-like 1 Neighboring gene STARR-seq mESC enhancer starr_01360 Neighboring gene inhibin alpha Neighboring gene STARR-positive B cell enhancer ABC_E5772 Neighboring gene STARR-positive B cell enhancer ABC_E5773 Neighboring gene STARR-positive B cell enhancer ABC_E4325 Neighboring gene predicted gene 15183 Neighboring gene solute carrier family 4 (anion exchanger), member 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification. Zi Z, et al. Nat Commun, 2022 Apr 1. PMID 35365663, Free PMC Article
  2. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway. Tian M, et al. J Cell Mol Med, 2021 Mar. PMID 33486894, Free PMC Article
  3. Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1. Morén A, et al. J Biol Chem, 2011 Jan 7. PMID 20974850, Free PMC Article
  4. LIP1, a cytoplasmic protein functionally linked to the Peutz-Jeghers syndrome kinase LKB1. Smith DP, et al. Hum Mol Genet, 2001 Dec 1. PMID 11741830
  5. Proteomic and yeast 2-hybrid screens to identify PTEN binding partners. Tibarewal P, et al. Adv Biol Regul, 2024 Jan. PMID 37839992

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
    Title: Quantitative phosphoproteomic analyses identify STK11IP as a lysosome-specific substrate of mTORC1 that regulates lysosomal acidification.
  2. LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
    Title: LKB1IP promotes pathological cardiac hypertrophy by targeting PTEN/Akt signalling pathway.
  3. LKB1 and LIP1 provide negative control of TGFbeta signaling.
    Title: Negative regulation of TGFβ signaling by the kinase LKB1 and the scaffolding protein LIP1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (1) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein kinase binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in protein localization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein localization IEA
Inferred from Electronic Annotation
more info
  
involved_in protein localization ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in intracellular membrane-bounded organelle IEA
Inferred from Electronic Annotation
more info
  
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine/threonine-protein kinase 11-interacting protein
Names
LKB1-interacting protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001432914.1 → NP_001419843.1  serine/threonine-protein kinase 11-interacting protein

    Status: VALIDATED

    Source sequence(s)
    AC115011
    UniProtKB/Swiss-Prot
    Q3TAA7, Q6P7J8, Q9DBT7

  2. NM_027886.4 → NP_082162.3  serine/threonine-protein kinase 11-interacting protein

    See identical proteins and their annotated locations for NP_082162.3

    Status: VALIDATED

    Source sequence(s)
    AC115011
    Consensus CDS
    CCDS15079.1
    UniProtKB/Swiss-Prot
    Q3TAA7, Q6P7J8, Q9DBT7
    Related
    ENSMUSP00000027414.10, ENSMUST00000027414.16
    Conserved Domains (4) summary
    sd00031
    Location:211 → 233
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:234 → 274
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236 → 291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:4 → 94
    LIP1; LKB1 serine/threonine kinase interacting protein 1

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000067.7 Reference GRCm39 C57BL/6J

    Range
    75498173..75513979
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_030243043.1 → XP_030098903.1  serine/threonine-protein kinase 11-interacting protein isoform X2

  2. XM_036153689.1 → XP_036009582.1  serine/threonine-protein kinase 11-interacting protein isoform X1

    Related
    ENSMUST00000140963.8
    Conserved Domains (3) summary
    COG4886
    Location:14 → 318
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00031
    Location:124 → 146
    LRR_1; leucine-rich repeat [structural motif]
    cd21340
    Location:104 → 234
    PPP1R42; protein phosphatase 1 regulatory subunit 42
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q3TAA7.1 GenPept UniProtKB/Swiss-Prot:Q3TAA7

Gene LinkOut

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