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STK11IP serine/threonine kinase 11 interacting protein [ Homo sapiens (human) ]

Gene ID: 114790, updated on 7-Jun-2020

Summary

Official Symbol
STK11IPprovided by HGNC
Official Full Name
serine/threonine kinase 11 interacting proteinprovided by HGNC
Primary source
HGNC:HGNC:19184
See related
Ensembl:ENSG00000144589 MIM:607172
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LIP1; LKB1IP; STK11IP1
Expression
Broad expression in testis (RPKM 10.6), spleen (RPKM 4.9) and 24 other tissues See more
Orthologs

Genomic context

See STK11IP in Genome Data Viewer
Location:
2q35
Exon count:
29
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (219597857..219616451)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (220462593..220481173)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene inhibin subunit alpha Neighboring gene RN7SK pseudogene 213 Neighboring gene solute carrier family 4 member 3 Neighboring gene CRISPRi-validated cis-regulatory element chr2.6714

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1898

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein kinase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
neutrophil degranulation TAS
Traceable Author Statement
more info
 
protein localization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein localization IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
azurophil granule lumen TAS
Traceable Author Statement
more info
 
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
lysosomal membrane HDA PubMed 

General protein information

Preferred Names
serine/threonine-protein kinase 11-interacting protein
Names
LKB1-interacting protein 1
STK11 interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_052902.4NP_443134.3  serine/threonine-protein kinase 11-interacting protein

    Status: VALIDATED

    Source sequence(s)
    AC009955, BC014114, BC034051, HY001118
    Consensus CDS
    CCDS46521.2
    UniProtKB/Swiss-Prot
    Q8N1F8
    UniProtKB/TrEMBL
    C9JQV3
    Related
    ENSP00000389383.1, ENST00000456909.6
    Conserved Domains (4) summary
    COG4886
    Location:101301
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:160187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam15904
    Location:493
    LIP1; LKB1 serine/threonine kinase interacting protein 1
    cl19201
    Location:668719
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    219597857..219616451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011510527.3XP_011508829.1  serine/threonine-protein kinase 11-interacting protein isoform X2

    Conserved Domains (6) summary
    cd00116
    Location:110289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:160187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234275
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:493
    LIP1; LKB1 serine/threonine kinase interacting protein 1
    cl19201
    Location:668719
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA
  2. XM_011510526.1XP_011508828.1  serine/threonine-protein kinase 11-interacting protein isoform X1

    Conserved Domains (6) summary
    cd00116
    Location:110289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:160187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234275
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:493
    LIP1; LKB1 serine/threonine kinase interacting protein 1
    cl19201
    Location:668719
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA
  3. XM_011510529.1XP_011508831.1  serine/threonine-protein kinase 11-interacting protein isoform X4

    Conserved Domains (5) summary
    cd00116
    Location:110289
    LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
    sd00033
    Location:160187
    LRR_RI; leucine-rich repeat [structural motif]
    pfam12799
    Location:234275
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:236291
    LRR_8; Leucine rich repeat
    pfam15904
    Location:493
    LIP1; LKB1 serine/threonine kinase interacting protein 1
  4. XM_011510528.2XP_011508830.1  serine/threonine-protein kinase 11-interacting protein isoform X3

    Conserved Domains (1) summary
    cl19201
    Location:313364
    HypA; Hydrogenase/urease nickel incorporation, metallochaperone, hypA

RNA

  1. XR_002959069.1 RNA Sequence

  2. XR_922833.1 RNA Sequence

  3. XR_002959068.1 RNA Sequence

  4. XR_922834.2 RNA Sequence

  5. XR_922835.2 RNA Sequence

    Related
    ENST00000475396.5
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