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TP73 tumor protein p73 [ Homo sapiens (human) ]

Gene ID: 7161, updated on 3-Jun-2018
Official Symbol
TP73provided by HGNC
Official Full Name
tumor protein p73provided by HGNC
Primary source
HGNC:HGNC:12003
See related
Ensembl:ENSG00000078900 MIM:601990; Vega:OTTHUMG00000000610
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P73
Summary
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Expression
Broad expression in skin (RPKM 3.5), prostate (RPKM 1.2) and 14 other tissues See more
Orthologs
See TP73 in Genome Data Viewer
Location:
1p36.32
Exon count:
16
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 1 NC_000001.11 (3652565..3736201)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3569129..3652765)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1 like Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene uncharacterized LOC105378610 Neighboring gene uncharacterized LOC105378609 Neighboring gene TP73 antisense RNA 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene small integral membrane protein 1 (Vel blood group)

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces phosphorylation of p73 at tyrosine reside 99, leading to promote its translocation to the nuclear matrix in neuronal cells PubMed
tat HIV-1 Tat induces accumulation and activation of p73 in neuronal cells PubMed
tat HIV-1 Tat-mediated inhibition of miR-196a leads to upregulation of p73 and c-ABL protein expression in cells PubMed
tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
tat Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF, and requires the cysteine-rich domain (amino acids 30 to 40) of Tat, which binds to the N-terminal region (amino acids 1 to 120) of p73 PubMed

Go to the HIV-1, Human Interaction Database

  • ATM Signaling Pathway, organism-specific biosystem (from WikiPathways)
    ATM Signaling Pathway, organism-specific biosystemAtaxia-telangiectasia (A-T) is a highly pleiotropic, autosomal recessive disease that leads to multisystem defects and has an intricate cellular phenotype, all linked to the functional inactivation o...
  • Activation of BH3-only proteins, organism-specific biosystem (from REACTOME)
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  • Activation of PUMA and translocation to mitochondria, organism-specific biosystem (from REACTOME)
    Activation of PUMA and translocation to mitochondria, organism-specific biosystemPuma is transactivated in a p53-dependent manner and by E2F1. Activated Puma is translocated to mitochondria.
  • Apoptosis, organism-specific biosystem (from WikiPathways)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • Apoptosis, organism-specific biosystem (from REACTOME)
    Apoptosis, organism-specific biosystemApoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and ...
  • DNA Damage Response (only ATM dependent), organism-specific biosystem (from WikiPathways)
    DNA Damage Response (only ATM dependent), organism-specific biosystemThis is the second pathway out of two pathways which deals with DNA damage response. It has two central gene products (ATM and TP53) which are connected with the first DNA damage response pathway. In...
  • Direct p53 effectors, organism-specific biosystem (from Pathway Interaction Database)
    Direct p53 effectors, organism-specific biosystem
    Direct p53 effectors
  • E2F transcription factor network, organism-specific biosystem (from Pathway Interaction Database)
    E2F transcription factor network, organism-specific biosystem
    E2F transcription factor network
  • Gene Expression, organism-specific biosystem (from REACTOME)
    Gene Expression, organism-specific biosystemGene Expression covers the pathways by which genomic DNA is transcribed to yield RNA, the regulation of these transcription processes, and the pathways by which newly-made RNA Transcripts are process...
  • Generic Transcription Pathway, organism-specific biosystem (from REACTOME)
    Generic Transcription Pathway, organism-specific biosystemOVERVIEW OF TRANSCRIPTION REGULATION: Detailed studies of gene transcription regulation in a wide variety of eukaryotic systems has revealed the general principles and mechanisms by which cell- or t...
  • Hippo signaling pathway, organism-specific biosystem (from KEGG)
    Hippo signaling pathway, organism-specific biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Hippo signaling pathway, conserved biosystem (from KEGG)
    Hippo signaling pathway, conserved biosystemHippo signaling is an evolutionarily conserved signaling pathway that controls organ size from flies to humans. In humans and mice, the pathway consists of the MST1 and MST2 kinases, their cofactor S...
  • Intrinsic Pathway for Apoptosis, organism-specific biosystem (from REACTOME)
    Intrinsic Pathway for Apoptosis, organism-specific biosystemThe intrinsic (Bcl-2 inhibitable or mitochondrial) pathway of apoptosis functions in response to various types of intracellular stress including growth factor withdrawal, DNA damage, unfolding stress...
  • Measles, organism-specific biosystem (from KEGG)
    Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Measles, conserved biosystem (from KEGG)
    Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Programmed Cell Death, organism-specific biosystem (from REACTOME)
    Programmed Cell Death, organism-specific biosystemCell death is a fundamental cellular response that has a crucial role in shaping our bodies during development and in regulating tissue homeostasis by eliminating unwanted cells. There are a number o...
  • Regulation of TP53 Activity, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity, organism-specific biosystemProtein stability and transcriptional activity of TP53 (p53) tumor suppressor are regulated by post-translational modifications that include ubiquitination, phosphorylation, acetylation, methylation,...
  • Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystem (from REACTOME)
    Regulation of TP53 Activity through Association with Co-factors, organism-specific biosystemAssociation of TP53 (p53) with various transcriptional co-factors can promote, inhibit or provide specificity towards either transcription of cell cycle arrest genes or transcription of cell death ge...
  • Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystem (from WikiPathways)
    Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways, organism-specific biosystemIn this model, we provide an integrated view of Sudden Infant Death Syndrome (SIDS) at the level of implicated tissues, signaling networks and genetics. The purpose of this model is to serve as an ov...
  • TP53 Network, organism-specific biosystem (from WikiPathways)
    TP53 Network, organism-specific biosystemP53 is not a lonely genome guardian, it operates with the assistance of p73 and p63 within a complex network including distinct but complementary pathways. This protein family presents a high le...
  • TP53 Regulates Transcription of Caspase Activators and Caspases, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Caspase Activators and Caspases, organism-specific biosystemTP53 (p53) transcriptionally regulates cytosolic caspase activators, such as APAF1, PIDD1, and NLRC4, and caspases themselves, such as CASP1, CASP6 and CASP10. These caspases and their activators are...
  • TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Cell Death Genes, organism-specific biosystemThe tumor suppressor TP53 (p53) exerts its tumor suppressive role in part by regulating transcription of a number of genes involved in cell death, mainly apoptotic cell death. The majority of apoptot...
  • TP53 Regulates Transcription of Death Receptors and Ligands, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Death Receptors and Ligands, organism-specific biosystemPro-apoptotic transcriptional targets of TP53 are TRAIL death receptors TNFRSF10A (DR4), TNFRSF10B (DR5), TNFRSF10C (DcR1) and TNFRSF10D (DcR2), as well as the FASL/CD95L death receptor FAS (CD95). T...
  • TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystem (from REACTOME)
    TP53 Regulates Transcription of Genes Involved in Cytochrome C Release, organism-specific biosystemApoptotic transcriptional targets of TP53 include genes that regulate the permeability of the mitochondrial membrane and/or cytochrome C release, such as BAX, BID, PMAIP1 (NOXA), BBC3 (PUMA) and prob...
  • TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, organism-specific biosystem (from REACTOME)
    TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain, organism-specific biosystemThe exact mechanisms of action of several other pro-apoptotic TP53 (p53) targets, such as TP53I3 (PIG3), RABGGTA, BCL2L14, BCL6, NDRG1 and PERP, remain uncertain (Attardi et al. 2000, Guo et al. 2001...
  • Transcriptional Regulation by TP53, organism-specific biosystem (from REACTOME)
    Transcriptional Regulation by TP53, organism-specific biosystemThe tumor suppressor TP53 (encoded by the gene p53) is a transcription factor. Under stress conditions, it recognizes specific responsive DNA elements and thus regulates the transcription of many gen...
  • p53 signaling pathway, organism-specific biosystem (from KEGG)
    p53 signaling pathway, organism-specific biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
  • p53 signaling pathway, conserved biosystem (from KEGG)
    p53 signaling pathway, conserved biosystemp53 activation is induced by a number of stress signals, including DNA damage, oxidative stress and activated oncogenes. The p53 protein is employed as a transcriptional activator of p53-regulated ge...
Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
MDM2/MDM4 family protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISA
Inferred from Sequence Alignment
more info
 
RNA polymerase II transcription factor activity, sequence-specific DNA binding ISM
Inferred from Sequence Model
more info
PubMed 
RNA polymerase II transcription factor activity, sequence-specific DNA binding NAS
Non-traceable Author Statement
more info
PubMed 
identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
p53 binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription regulatory region DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
mismatch repair TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
Preferred Names
tumor protein p73
Names
p53-like transcription factor
p53-related protein

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017035.2 RefSeqGene

    Range
    5001..88637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126240.2NP_001119712.1  tumor protein p73 isoform b

    See identical proteins and their annotated locations for NP_001119712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as deltaN p73 alpha) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    Consensus CDS
    CCDS44049.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367537.4, OTTHUMP00000003478, ENST00000378288.8, OTTHUMT00000009531
    Conserved Domains (4) summary
    cd09571
    Location:438502
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:442501
    SAM; Sterile alpha motif
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  2. NM_001126241.2NP_001119713.1  tumor protein p73 isoform c

    See identical proteins and their annotated locations for NP_001119713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c, also known as deltaN p73 beta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055066, AI094238, AL136528
    Consensus CDS
    CCDS44050.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367534.1, OTTHUMP00000003479, ENST00000378285.5, OTTHUMT00000009532
    Conserved Domains (2) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  3. NM_001126242.2NP_001119714.1  tumor protein p73 isoform d

    See identical proteins and their annotated locations for NP_001119714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d, also known as deltaN p73 gamma) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, AY040829
    Consensus CDS
    CCDS44051.1
    UniProtKB/Swiss-Prot
    O15350
    UniProtKB/TrEMBL
    A0A0C4DFW9
    Related
    ENSP00000367529.1, OTTHUMP00000003480, ENST00000378280.5, OTTHUMT00000009533
    Conserved Domains (2) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  4. NM_001204184.1NP_001191113.1  tumor protein p73 isoform h

    See identical proteins and their annotated locations for NP_001191113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h, also known as TA p73 beta) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055066, AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55566.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000346423.4, OTTHUMP00000003477, ENST00000354437.8, OTTHUMT00000009530
    Conserved Domains (2) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
  5. NM_001204185.1NP_001191114.1  tumor protein p73 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (i, also known as TA p73 gamma) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, AY040829, Y11416
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
  6. NM_001204186.1NP_001191115.1  tumor protein p73 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (j, also known as TA p73 delta) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS59965.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000475143.1, OTTHUMP00000272880, ENST00000604074.5, OTTHUMT00000469084
    Conserved Domains (2) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:346384
    P53_tetramer; P53 tetramerisation motif
  7. NM_001204187.1NP_001191116.1  tumor protein p73 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (k, also known as TA p73 epsilon) has a shorter and distinct internal segment compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55567.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000350366.3, ENST00000357733.7
    Conserved Domains (3) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:445470
    SAM_superfamily; SAM (Sterile alpha motif )
  8. NM_001204188.1NP_001191117.1  tumor protein p73 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks two alternate coding exons compared to variant 1. The resulting isoform (l, also known as TA p73 zeta) lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55568.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000340740.4, ENST00000346387.8
    Conserved Domains (4) summary
    smart00454
    Location:400454
    SAM; Sterile alpha motif
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:400455
    SAM_superfamily; SAM (Sterile alpha motif )
  9. NM_001204189.1NP_001191118.1  tumor protein p73 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3, also known as deltaN p73 delta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  10. NM_001204190.1NP_001191119.1  tumor protein p73 isoform f

    See identical proteins and their annotated locations for NP_001191119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (f, also known as deltaN p73 epsilon) has a shorter and distinct N-terminus and a shorter and distinct internal segment compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (3) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:396421
    SAM_superfamily; SAM (Sterile alpha motif )
  11. NM_001204191.1NP_001191120.1  tumor protein p73 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The resulting isoform (g, also known as deltaN p73 zeta) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (4) summary
    smart00454
    Location:351405
    SAM; Sterile alpha motif
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:351406
    SAM_superfamily; SAM (Sterile alpha motif )
  12. NM_001204192.1NP_001191121.1  tumor protein p73 isoform m

    See identical proteins and their annotated locations for NP_001191121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (m) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AK302118, AK310432, AL136528
    Consensus CDS
    CCDS55569.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367539.4, OTTHUMP00000272881, ENST00000378290.4, OTTHUMT00000469088
    Conserved Domains (4) summary
    cd09571
    Location:416480
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:420479
    SAM; Sterile alpha motif
    pfam00870
    Location:42238
    P53; P53 DNA-binding domain
    pfam07710
    Location:274313
    P53_tetramer; P53 tetramerization motif
  13. NM_005427.3NP_005418.1  tumor protein p73 isoform a

    See identical proteins and their annotated locations for NP_005418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), encodes isoform a, also known as TA p73 alpha.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS49.1
    UniProtKB/Swiss-Prot
    O15350
    UniProtKB/TrEMBL
    A0A024R4C3
    Related
    ENSP00000367545.4, OTTHUMP00000000662, ENST00000378295.8, OTTHUMT00000001468
    Conserved Domains (4) summary
    cd09571
    Location:487551
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:491550
    SAM; Sterile alpha motif
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p12 Primary Assembly

    Range
    3652565..3736201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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