Format

Send to:

Choose Destination

TP73 tumor protein p73 [ Homo sapiens (human) ]

Gene ID: 7161, updated on 1-Aug-2020

Summary

Official Symbol
TP73provided by HGNC
Official Full Name
tumor protein p73provided by HGNC
Primary source
HGNC:HGNC:12003
See related
Ensembl:ENSG00000078900 MIM:601990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P73
Summary
This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
Expression
Broad expression in skin (RPKM 3.5), prostate (RPKM 1.2) and 14 other tissues See more
Orthologs

Genomic context

See TP73 in Genome Data Viewer
Location:
1p36.32
Exon count:
16
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (3652516..3736201)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3569129..3652765)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene tumor protein p63 regulated 1 like Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene TP73 antisense RNA 3 Neighboring gene uncharacterized LOC105378609 Neighboring gene TP73 antisense RNA 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene small integral membrane protein 1 (Vel blood group)

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Copy number response

Description
Copy number response
Haploinsufficency

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page
Triplosensitivity

No evidence available (Last evaluated (2012-07-06)

ClinGen Genome Curation Page

NHGRI GWAS Catalog

Description
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat induces phosphorylation of p73 at tyrosine reside 99, leading to promote its translocation to the nuclear matrix in neuronal cells PubMed
tat HIV-1 Tat induces accumulation and activation of p73 in neuronal cells PubMed
tat HIV-1 Tat-mediated inhibition of miR-196a leads to upregulation of p73 and c-ABL protein expression in cells PubMed
tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
tat Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF, and requires the cysteine-rich domain (amino acids 30 to 40) of Tat, which binds to the N-terminal region (amino acids 1 to 120) of p73 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
activation of MAPK activity IEA
Inferred from Electronic Annotation
more info
 
cell cycle arrest IEA
Inferred from Electronic Annotation
more info
 
cellular response to DNA damage stimulus IDA
Inferred from Direct Assay
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage TAS
Traceable Author Statement
more info
PubMed 
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
Inferred from Direct Assay
more info
PubMed 
kidney development IEA
Inferred from Electronic Annotation
more info
 
mismatch repair TAS
Traceable Author Statement
more info
PubMed 
negative regulation of cardiac muscle cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of neuron differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of cell cycle arrest IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of oligodendrocyte differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway TAS
Traceable Author Statement
more info
 
positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process TAS
Traceable Author Statement
more info
 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of hematopoietic stem cell differentiation TAS
Traceable Author Statement
more info
 
regulation of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
response to drug IEA
Inferred from Electronic Annotation
more info
 
response to organonitrogen compound IEA
Inferred from Electronic Annotation
more info
 
viral process IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IDA
Inferred from Direct Assay
more info
 
cell junction IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
mitochondrion IEA
Inferred from Electronic Annotation
more info
 
nuclear chromatin ISA
Inferred from Sequence Alignment
more info
 
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
tumor protein p73
Names
p53-like transcription factor
p53-related protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_017035.2 RefSeqGene

    Range
    4952..88637
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001126240.3NP_001119712.1  tumor protein p73 isoform b

    See identical proteins and their annotated locations for NP_001119712.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as deltaN p73 alpha) has a shorter and distinct N-terminus compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    Consensus CDS
    CCDS44049.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367537.4, ENST00000378288.8
    Conserved Domains (4) summary
    cd09571
    Location:438502
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:442501
    SAM; Sterile alpha motif
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  2. NM_001126241.3NP_001119713.1  tumor protein p73 isoform c

    See identical proteins and their annotated locations for NP_001119713.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c, also known as deltaN p73 beta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055066, AI094238, AL136528
    Consensus CDS
    CCDS44050.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367534.1, ENST00000378285.5
    Conserved Domains (2) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  3. NM_001126242.3NP_001119714.1  tumor protein p73 isoform d

    See identical proteins and their annotated locations for NP_001119714.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d, also known as deltaN p73 gamma) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, AY040829
    Consensus CDS
    CCDS44051.1
    UniProtKB/Swiss-Prot
    O15350
    UniProtKB/TrEMBL
    A0A0C4DFW9
    Related
    ENSP00000367529.1, ENST00000378280.5
    Conserved Domains (2) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  4. NM_001204184.2NP_001191113.1  tumor protein p73 isoform h

    See identical proteins and their annotated locations for NP_001191113.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h, also known as TA p73 beta) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055066, AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55566.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000346423.4, ENST00000354437.8
    Conserved Domains (2) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
  5. NM_001204185.2NP_001191114.1  tumor protein p73 isoform i

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (i, also known as TA p73 gamma) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, AY040829, Y11416
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
  6. NM_001204186.2NP_001191115.1  tumor protein p73 isoform j

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (j, also known as TA p73 delta) has a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS59965.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000475143.1, ENST00000604074.5
    Conserved Domains (2) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:346384
    P53_tetramer; P53 tetramerisation motif
  7. NM_001204187.1NP_001191116.1  tumor protein p73 isoform k

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (k, also known as TA p73 epsilon) has a shorter and distinct internal segment compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55567.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000350366.3, ENST00000357733.7
    Conserved Domains (3) summary
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:445470
    SAM_superfamily; SAM (Sterile alpha motif )
  8. NM_001204188.1NP_001191117.1  tumor protein p73 isoform l

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) lacks two alternate coding exons compared to variant 1. The resulting isoform (l, also known as TA p73 zeta) lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS55568.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000340740.4, ENST00000346387.8
    Conserved Domains (4) summary
    smart00454
    Location:400454
    SAM; Sterile alpha motif
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:400455
    SAM_superfamily; SAM (Sterile alpha motif )
  9. NM_001204189.2NP_001191118.1  tumor protein p73 isoform e

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3, also known as deltaN p73 delta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (2) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
  10. NM_001204190.2NP_001191119.1  tumor protein p73 isoform f

    See identical proteins and their annotated locations for NP_001191119.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (f, also known as deltaN p73 epsilon) has a shorter and distinct N-terminus and a shorter and distinct internal segment compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (3) summary
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:396421
    SAM_superfamily; SAM (Sterile alpha motif )
  11. NM_001204191.2NP_001191120.1  tumor protein p73 isoform g

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The resulting isoform (g, also known as deltaN p73 zeta) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
    Source sequence(s)
    AB055065, AI094238, AL136528
    UniProtKB/Swiss-Prot
    O15350
    Conserved Domains (4) summary
    smart00454
    Location:351405
    SAM; Sterile alpha motif
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
    cl15755
    Location:351406
    SAM_superfamily; SAM (Sterile alpha motif )
  12. NM_001204192.2NP_001191121.1  tumor protein p73 isoform m

    See identical proteins and their annotated locations for NP_001191121.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (m) is shorter at the N-terminus compared to isoform a.
    Source sequence(s)
    AI094238, AK302118, AK310432, AL136528
    Consensus CDS
    CCDS55569.1
    UniProtKB/Swiss-Prot
    O15350
    Related
    ENSP00000367539.4, ENST00000378290.4
    Conserved Domains (4) summary
    cd09571
    Location:416480
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:420479
    SAM; Sterile alpha motif
    pfam00870
    Location:42238
    P53; P53 DNA-binding domain
    pfam07710
    Location:274313
    P53_tetramer; P53 tetramerization motif
  13. NM_005427.4NP_005418.1  tumor protein p73 isoform a

    See identical proteins and their annotated locations for NP_005418.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), encodes isoform a, also known as TA p73 alpha.
    Source sequence(s)
    AI094238, AL136528, Y11416
    Consensus CDS
    CCDS49.1
    UniProtKB/Swiss-Prot
    O15350
    UniProtKB/TrEMBL
    A0A024R4C3
    Related
    ENSP00000367545.4, ENST00000378295.9
    Conserved Domains (4) summary
    cd09571
    Location:487551
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:491550
    SAM; Sterile alpha motif
    pfam00870
    Location:113309
    P53; P53 DNA-binding domain
    pfam07710
    Location:345384
    P53_tetramer; P53 tetramerization motif

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109.20200522

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    3652516..3736201
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center