U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Trp73 transformation related protein 73 [ Mus musculus (house mouse) ]

Gene ID: 22062, updated on 20-Feb-2024

Summary

Official Symbol
Trp73provided by MGI
Official Full Name
transformation related protein 73provided by MGI
Primary source
MGI:MGI:1336991
See related
Ensembl:ENSMUSG00000029026 AllianceGenome:MGI:1336991
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p73; Tp73; TAp73; deltaNp73
Summary
This gene encodes tumor protein p73, which is a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include p53, p63, and p73 and have high sequence similarity to one another, which allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways involving direct or indirect protein interactions, resulting in regulation of the same target gene promoters or regulation of each other's promoters. The p73 protein is expressed at very low levels in normal tissues and is differentially expressed in a number of tumors. The p73 gene expresses at least 35 mRNA variants due to the use of alternate promoters, alternate translation initiation sites, and multiple splice variations. Theoretically this can account for 29 different p73 isoforms; however, the biological validity and the full-length nature of most variants have not been determined. [provided by RefSeq, Jul 2008]
Expression
Biased expression in lung adult (RPKM 1.7), ovary adult (RPKM 1.4) and 13 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See Trp73 in Genome Data Viewer
Location:
4 E2; 4 83.79 cM
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (154140706..154224332, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (154056249..154139875, complement)

Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene leucine rich repeat containing 47 Neighboring gene small integral membrane protein 1 Neighboring gene coiled-coil domain containing 27 Neighboring gene STARR-seq mESC enhancer starr_12227 Neighboring gene STARR-seq mESC enhancer starr_12228 Neighboring gene STARR-positive B cell enhancer ABC_E4737 Neighboring gene predicted gene, 26036 Neighboring gene WD repeat containing, antisense to Trp73 Neighboring gene STARR-positive B cell enhancer ABC_E1045 Neighboring gene transformation related protein 63 regulated 1 like

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables DNA-binding transcription factor activity ISO
Inferred from Sequence Orthology
more info
PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
 
enables DNA-binding transcription factor activity, RNA polymerase II-specific ISO
Inferred from Sequence Orthology
more info
 
enables DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables MDM2/MDM4 family protein binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
Inferred from Sequence Orthology
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables p53 binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein kinase binding ISO
Inferred from Sequence Orthology
more info
 
enables sequence-specific DNA binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription cis-regulatory region binding ISO
Inferred from Sequence Orthology
more info
 
enables transcription corepressor binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
acts_upstream_of_or_within DNA damage response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in DNA damage response ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cell cycle IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within cerebrospinal fluid secretion IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within digestive tract morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within hippocampus development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of cell population proliferation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of neuron differentiation ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in positive regulation of DNA-templated transcription ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of MAPK cascade ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of apoptotic process ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within positive regulation of cell size IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of lung ciliated cell differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of oligodendrocyte differentiation ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within post-embryonic development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in protein tetramerization IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_negative_effect regulation of cell cycle ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within regulation of gene expression ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of mitotic cell cycle ISO
Inferred from Sequence Orthology
more info
PubMed 
acts_upstream_of_or_within regulation of neuron apoptotic process IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
part_of chromatin ISO
Inferred from Sequence Orthology
more info
 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in intracellular membrane-bounded organelle ISO
Inferred from Sequence Orthology
more info
 
located_in nucleoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001126330.1NP_001119802.1  tumor protein p73 isoform b

    See identical proteins and their annotated locations for NP_001119802.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) is an alternate promoter product; it lacks a few of 5' exons but has an alternate 5' exon, as compared to variant 1. The resulting isoform b, also known as DNp73alpha, has a shorter and different N-terminus, as compared to isoform a.
    Source sequence(s)
    AK014503, AK139633, Y19235
    Consensus CDS
    CCDS51397.1
    UniProtKB/TrEMBL
    Z4YK94
    Related
    ENSMUSP00000114418.2, ENSMUST00000133533.8
    Conserved Domains (5) summary
    cd09571
    Location:440504
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    smart00454
    Location:444504
    SAM; Sterile alpha motif
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
    pfam09646
    Location:499589
    Gp37; Gp37 protein
  2. NM_001126331.1NP_001119803.1  tumor protein p73 isoform c

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) is an alternate promoter product; it lacks a few of 5' exons and two internal exons in the 3' region, but has an alternate 5' exon, as compared to variant 1. The resulting isoform c, also known as DNp73zeta, has a shorter and different N-terminus and lacks an internal segment in the C-terminal region, as compared to isoform a.
    Source sequence(s)
    AK014503, AK017412, AK139633
    Consensus CDS
    CCDS51396.1
    UniProtKB/Swiss-Prot
    Q9JJP2
    UniProtKB/TrEMBL
    Q9D6A3
    Related
    ENSMUSP00000095368.5, ENSMUST00000097762.11
    Conserved Domains (5) summary
    smart00454
    Location:353408
    SAM; Sterile alpha motif
    pfam00870
    Location:64260
    P53; P53 DNA-binding domain
    pfam07710
    Location:296335
    P53_tetramer; P53 tetramerization motif
    pfam09646
    Location:403493
    Gp37; Gp37 protein
    cl15755
    Location:353408
    SAM_superfamily; SAM (Sterile alpha motif )
  3. NM_011642.4NP_035772.3  tumor protein p73 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes isoform a, also known as TAp73alpha.
    Source sequence(s)
    AL806525
    Consensus CDS
    CCDS19009.2
    UniProtKB/Swiss-Prot
    B1AX89, B1AX90, Q3UT91, Q9CU77, Q9JJP1, Q9JJP2, Q9WUJ0
    UniProtKB/TrEMBL
    Z4YK94
    Related
    ENSMUSP00000101269.4, ENSMUST00000105644.10
    Conserved Domains (4) summary
    cd09571
    Location:481545
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    pfam00870
    Location:105301
    P53; P53 DNA-binding domain
    pfam07710
    Location:338376
    P53_tetramer; P53 tetramerisation motif
    pfam09646
    Location:540630
    Gp37; Gp37 protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000070.7 Reference GRCm39 C57BL/6J

    Range
    154140706..154224332 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006538720.2XP_006538783.2  tumor protein p73 isoform X1

    UniProtKB/TrEMBL
    Z4YK94
    Conserved Domains (4) summary
    cd08367
    Location:137316
    P53; P53 DNA-binding domain
    cd09571
    Location:499563
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    pfam07710
    Location:356392
    P53_tetramer; P53 tetramerisation motif
    pfam09646
    Location:558648
    Gp37; Gp37 protein
  2. XM_006538722.5XP_006538785.1  tumor protein p73 isoform X2

    See identical proteins and their annotated locations for XP_006538785.1

    UniProtKB/TrEMBL
    Z4YK94
    Conserved Domains (4) summary
    cd08367
    Location:56235
    P53; P53 DNA-binding domain
    cd09571
    Location:418482
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    pfam07710
    Location:275311
    P53_tetramer; P53 tetramerisation motif
    pfam09646
    Location:477567
    Gp37; Gp37 protein
  3. XM_006538723.3XP_006538786.1  tumor protein p73 isoform X3

    Conserved Domains (4) summary
    cd08367
    Location:4101
    P53; P53 DNA-binding domain
    cd09571
    Location:284348
    SAM_tumor-p73; SAM domain of tumor-p73 proteins
    pfam07710
    Location:141177
    P53_tetramer; P53 tetramerisation motif
    pfam09646
    Location:343433
    Gp37; Gp37 protein