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TNP2 transition protein 2 [ Homo sapiens (human) ]

Gene ID: 7142, updated on 17-Jun-2019

Summary

Official Symbol
TNP2provided by HGNC
Official Full Name
transition protein 2provided by HGNC
Primary source
HGNC:HGNC:11952
See related
Ensembl:ENSG00000178279 MIM:190232
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TP2
Expression
Restricted expression toward testis (RPKM 12.9) See more
Orthologs

Genomic context

See TNP2 in Genome Data Viewer
Location:
16p13.13
Exon count:
2
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (11267857..11269325, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11361714..11363160, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371082 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 4 Neighboring gene suppressor of cytokine signaling 1 Neighboring gene protamine 3 Neighboring gene protamine 2

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic variants associated with disordered eating.
NHGRI GWA Catalog
Genome-wide meta-analysis identifies novel multiple sclerosis susceptibility loci.
NHGRI GWA Catalog
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.
NHGRI GWA Catalog

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of transition protein 2 (during histone to protamine replacement) (TNP2) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC116783, MGC116785

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
penetration of zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of protein processing ISS
Inferred from Sequence or Structural Similarity
more info
 
spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
spermatogenesis, exchange of chromosomal proteins ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
nuclear nucleosome ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
nuclear transition protein 2
Names
TP-2
transition protein 2 (during histone to protamine replacement)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_005425.5NP_005416.1  nuclear transition protein 2

    See identical proteins and their annotated locations for NP_005416.1

    Status: VALIDATED

    Source sequence(s)
    AC009121, AI220577, BX282422, X63758
    Consensus CDS
    CCDS45410.1
    UniProtKB/Swiss-Prot
    Q05952
    UniProtKB/TrEMBL
    Q4VB56
    Related
    ENSP00000325738.3, ENST00000312693.4
    Conserved Domains (1) summary
    pfam01254
    Location:1134
    TP2; Nuclear transition protein 2

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    11267857..11269325 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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