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Tnp2 transition protein 2 [ Mus musculus (house mouse) ]

Gene ID: 21959, updated on 1-Mar-2024

Summary

Official Symbol
Tnp2provided by MGI
Official Full Name
transition protein 2provided by MGI
Primary source
MGI:MGI:98785
See related
Ensembl:ENSMUSG00000043050 AllianceGenome:MGI:98785
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
TP2; Tp-2
Summary
Predicted to enable zinc ion binding activity. Involved in positive regulation of protein processing and spermatogenesis, exchange of chromosomal proteins. Acts upstream of or within flagellated sperm motility; single fertilization; and spermatogenesis. Located in nucleus. Part of nucleosome. Is expressed in spermatid and testis. Orthologous to human TNP2 (transition protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis adult (RPKM 8790.1) See more
Orthologs
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Genomic context

See Tnp2 in Genome Data Viewer
Location:
16 A1; 16 5.83 cM
Exon count:
2
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (10605799..10606519, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (10787935..10788655, complement)

Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 53935 Neighboring gene STARR-seq mESC enhancer starr_40095 Neighboring gene STARR-positive B cell enhancer ABC_E3162 Neighboring gene suppressor of cytokine signaling 1 Neighboring gene protamine 3 Neighboring gene protamine 2

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in acrosome reaction IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within acrosome reaction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within binding of sperm to zona pellucida IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within flagellated sperm motility IGI
Inferred from Genetic Interaction
more info
PubMed 
acts_upstream_of_or_within multicellular organism development IEA
Inferred from Electronic Annotation
more info
 
involved_in penetration of zona pellucida IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within penetration of zona pellucida IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in sperm DNA condensation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in spermatogenesis IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within spermatogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in chromosome IEA
Inferred from Electronic Annotation
more info
 
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in male germ cell nucleus TAS
Traceable Author Statement
more info
PubMed 
part_of nucleosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in nucleus ISO
Inferred from Sequence Orthology
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
nuclear transition protein 2
Names
transition protein 2 (alt.)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_013694.4NP_038722.3  nuclear transition protein 2

    See identical proteins and their annotated locations for NP_038722.3

    Status: PROVISIONAL

    Source sequence(s)
    BC092529
    Consensus CDS
    CCDS27953.1
    UniProtKB/Swiss-Prot
    P11378, Q91XK4
    Related
    ENSMUSP00000053078.8, ENSMUST00000051297.9
    Conserved Domains (1) summary
    pfam01254
    Location:1113
    TP2; Nuclear transition protein 2

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000082.7 Reference GRCm39 C57BL/6J

    Range
    10605799..10606519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)