PRSS8 serine protease 8 [Macaca mulatta (Rhesus monkey)] - Gene

Summary

Official Symbol: PRSS8provided by VGNC
Official Full Name: serine protease 8provided by VGNC
Primary source: VGNC:VGNC:76433
See related: Ensembl:ENSMMUG00000002033
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Macaca mulatta
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Cercopithecidae; Cercopithecinae; Macaca
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 20

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
103	current	Mmul_10 (GCF_003339765.1)	20	NC_041773.1 (28558909..28563417, complement)
102	previous assembly	Mmul_8.0.1 (GCF_000772875.2)	20	NC_027912.1 (28950144..28954651)

Chromosome 20 - NC_041773.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Prostasin may be involved in follicular development, ovulation, and CL formation, whereas PN-1 may be present to regulate the proteolysis in these processes.[prostasin; protease nexin-1]
Title: Expression of prostasin serine protease and protease nexin-1 (PN-1) in rhesus monkey ovary during menstrual cycle and early pregnancy.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables serine-type endopeptidase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables sodium channel regulator activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in positive regulation of sodium ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in proteolysis	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: prostasin

Names: prostasin preproprotein; protease, serine 8

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001266588.1 → NP_001253517.1 prostasin precursor

See identical proteins and their annotated locations for NP_001253517.1

Status: PROVISIONAL

Source sequence(s)

JU476439

UniProtKB/TrEMBL

A0A5K1VGA7, G7NQY6

Related

ENSMMUP00000064156.1, ENSMMUT00000084358.1

Conserved Domains (2) summary

smart00020
Location:44 → 281

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:45 → 284

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Macaca mulatta Annotation Release 103 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Mmul_10 Primary Assembly

Genomic

NC_041773.1 Reference Mmul_10 Primary Assembly

Range

28558909..28563417 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015125992.2 → XP_014981478.1 prostasin isoform X1

UniProtKB/TrEMBL

F6TMC3, G7NQY6, H9ZBC7

Related

ENSMMUP00000002716.3, ENSMMUT00000002873.3

Conserved Domains (2) summary

smart00020
Location:38 → 275

Tryp_SPc; Trypsin-like serine protease

cd00190
Location:39 → 278

Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...