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PRSS8 serine protease 8 [ Homo sapiens (human) ]

Gene ID: 5652, updated on 6-Jan-2019


Official Symbol
PRSS8provided by HGNC
Official Full Name
serine protease 8provided by HGNC
Primary source
See related
Ensembl:ENSG00000052344 MIM:600823
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
This gene encodes a member of the peptidase S1 or chymotrypsin family of serine proteases. The encoded preproprotein is proteolytically processed to generate light and heavy chains that associate via a disulfide bond to form the heterodimeric enzyme. This enzyme is highly expressed in prostate epithelia and is one of several proteolytic enzymes found in seminal fluid. This protease exhibits trypsin-like substrate specificity, cleaving protein substrates at the carboxyl terminus of lysine or arginine residues. The encoded protease partially mediates proteolytic activation of the epithelial sodium channel, a regulator of sodium balance, and may also play a role in epithelial barrier formation. [provided by RefSeq, Feb 2016]
Broad expression in small intestine (RPKM 73.7), colon (RPKM 73.6) and 14 other tissues See more

Genomic context

See PRSS8 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 16 NC_000016.10 (31131433..31135762, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (31142754..31147151, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene branched chain ketoacid dehydrogenase kinase Neighboring gene lysine acetyltransferase 8 Neighboring gene serine protease 36 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 6

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Developmental Biology, organism-specific biosystem (from REACTOME)
    Developmental Biology, organism-specific biosystemAs a first step towards capturing the array of processes by which a fertilized egg gives rise to the diverse tissues of the body, examples of three kinds of processes have been annotated. These are a...
  • Formation of the cornified envelope, organism-specific biosystem (from REACTOME)
    Formation of the cornified envelope, organism-specific biosystemAs keratinocytes progress towards the upper epidermis, they undergo a unique process of cell death termed cornification (Eckhart et al. 2013). This involves the crosslinking of keratinocyte proteins ...
  • Keratinization, organism-specific biosystem (from REACTOME)
    Keratinization, organism-specific biosystemKeratins are the major structural protein of vertebrate epidermis, constituting up to 85% of a fully differentiated keratinocyte (Fuchs 1995). Keratins belong to a superfamily of intermediate filamen...


Products Interactant Other Gene Complex Source Pubs Description

General gene information



Gene Ontology Provided by GOA

Function Evidence Code Pubs
endopeptidase activity TAS
Traceable Author Statement
more info
protein binding IPI
Inferred from Physical Interaction
more info
serine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
serine-type peptidase activity TAS
Traceable Author Statement
more info
sodium channel regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
positive regulation of sodium ion transport IBA
Inferred from Biological aspect of Ancestor
more info
proteolysis IEA
Inferred from Electronic Annotation
more info
Component Evidence Code Pubs
anchored component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
extracellular space HDA PubMed 
extrinsic component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
integral component of membrane IEA
Inferred from Electronic Annotation
more info
plasma membrane IDA
Inferred from Direct Assay
more info
plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
channel-activating protease 1
protease, serine 8

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_002773.5NP_002764.1  prostasin preproprotein

    See identical proteins and their annotated locations for NP_002764.1

    Status: REVIEWED

    Source sequence(s)
    BC001462, L41351
    Consensus CDS
    ENSP00000319730.6, ENST00000317508.10
    Conserved Domains (2) summary
    Tryp_SPc; Trypsin-like serine protease
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly


  1. NC_000016.10 Reference GRCh38.p12 Primary Assembly

    31131433..31135762 complement
    GenBank, FASTA, Sequence Viewer (Graphics)
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