TNFAIP3 TNF alpha induced protein 3 [Homo sapiens (human)] - Gene

Summary

Official Symbol: TNFAIP3provided by HGNC
Official Full Name: TNF alpha induced protein 3provided by HGNC
Primary source: HGNC:HGNC:11896
See related: Ensembl:ENSG00000118503 MIM:191163
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: A20; AISBL; OTUD7C; TNFA1P2
Summary: This gene was identified as a gene whose expression is rapidly induced by the tumor necrosis factor (TNF). The protein encoded by this gene is a zinc finger protein and ubiqitin-editing enzyme, and has been shown to inhibit NF-kappa B activation as well as TNF-mediated apoptosis. The encoded protein, which has both ubiquitin ligase and deubiquitinase activities, is involved in the cytokine-mediated immune and inflammatory responses. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2012]
Expression: Broad expression in bone marrow (RPKM 156.2), appendix (RPKM 61.9) and 14 other tissues See more
Orthologs: mouse all

Genomic context

Location:: 6q23.3

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
109.20190607	current	GRCh38.p13 (GCF_000001405.39)	6	NC_000006.12 (137866317..137883312)
105	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (138188325..138204451)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Single-cell imaging revealed that RIPK3-dependent death caused inflammasome-dependent IL-1beta release from lipopolysaccharide-stimulated A20-deficient macrophages. Importantly, mutation of the A20 ZnF7 ubiquitin binding domain caused arthritis in mice, arguing that ZnF7-dependent inhibition of necroptosis is critical for A20 anti-inflammatory function in vivo.
Title: A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain.
this study shows that functional variants of TNFAIP3 are associated with systemic lupus erythematosus in a cohort of Chinese Han population
Title: Functional variants of TNFAIP3 are associated with systemic lupus erythematosus in a cohort of Chinese Han population.
Staphylococcus epidermidis-induced interleukin-1 beta and beta-defensin-2 expression in keratinocytes is regulated by the host molecule A20 (TNFAIP3) and may help S. epidermidis to persist on human skin.
Title: Staphylococcus epidermidis-induced Interleukin-1 Beta and Human Beta-defensin-2 Expression in Human Keratinocytes is Regulated by the Host Molecule A20 (TNFAIP3).
results implicate TNFAIP3 as a functionally important endogenous suppressor of ASK1 hyperactivation in the pathogenesis of nonalcoholic steatohepatitis (NASH) and identify it as a potential new molecular target for NASH therapy
Title: The deubiquitinating enzyme TNFAIP3 mediates inactivation of hepatic ASK1 and ameliorates nonalcoholic steatohepatitis.
Activation of ligand-inducible chimeric FGFR1 (iFGFR1) upregulated TNFAIP3 in an ERK2-dependent manner and TNFAIP3 is required for iFGFR1 activation-promoted ductal carcinoma in situ (DCIS) cell proliferation, tumor growth and progression. Knockout of TNFAIP3 blocks FGFR1 signaling-promoted DCIS cell proliferation suggesting that TNFAIP3 is required for FGFR1 signaling-promoted DCIS growth and progression.
Title: TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells.
TNFalpha contributes to the aggressive properties of triple negative breast cancer cell lines via upregulation of A20. A20 mediates pleiotropic effects of TNFalpha playing role in aggressive behaviors of TNBC subtype while its deficiency results in TNFalpha-induced apoptotic cell death in luminal breast cancer subtype.
Title: The pleiotropic effects of TNFα in breast cancer subtypes is regulated by TNFAIP3/A20.
these results suggest that MYD88L265P signaling can be enhanced by a second genetic alteration in TNFAIP3 and highlights a potential opportunity for therapeutic targeting.
Title: Loss of TNFAIP3 enhances MYD88<sub>L265P</sub>-driven signaling in non-Hodgkin lymphoma.
The expression of MiR-128-3p was significantly increased, while TNFAIP3 was decreased, the levels of IL-6 and IL-17 were also increased in the T cells of rheumatoid arthritis patients.
Title: Decreased MiR-128-3p alleviates the progression of rheumatoid arthritis by up-regulating the expression of TNFAIP3.
this study postulate that deregulation of the NF-kappaB pathway as a result of the TNFAIP3 rs2230926 aberration increases Sjogren's syndrome susceptibility
Title: TNFAIP3 F127C Coding Variation in Greek Primary Sjogren's Syndrome Patients.
This study showed that the expression of A20 was decreased in Behcet's disease (BD) patients with active uveitis but not in Vogt-Koyanagi-Harada (VKH) disease. Decreased expression of A20 may lead to an enhanced activation of proinflammatory Th17 cells, causing a reactivation of BD.
Title: Decreased expression of A20 is associated with ocular Behcet's disease (BD) but not with Vogt-Koyanagi-Harada (VKH) disease.

Submit: New GeneRIF Correction See all GeneRIFs (295)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Autoinflammatory syndrome, familial, Behcet-like MedGen: C4225218 OMIM: 616744 GeneReviews: Not available	Compare labs

NHGRI GWAS Catalog

Description
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sj&#x000c3;&#x000b6;gren's syndrome at 7q11.23. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A regulatory variant in CCR6 is associated with rheumatoid arthritis susceptibility. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetic variants near TNFAIP3 on 6q23 are associated with systemic lupus erythematosus. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genetics of rheumatoid arthritis contributes to biology and drug discovery. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Multiple common variants for celiac disease influencing immune gene expression. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study. NHGRI GWA Catalog NHGRI GWA CatalogPubMed
Two independent alleles at 6q23 associated with risk of rheumatoid arthritis. NHGRI GWA Catalog NHGRI GWA CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 and the viral protein Tat modulate the expression of tumor necrosis factor, alpha-induced protein 3 (TNFAIP3) in immature dendritic cells and monocyte-derived macrophages	PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

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CD40/CD40L signaling, organism-specific biosystem (from Pathway Interaction Database)
CD40/CD40L signaling, organism-specific biosystem
CD40/CD40L signaling
Canonical NF-kappaB pathway, organism-specific biosystem (from Pathway Interaction Database)
Canonical NF-kappaB pathway, organism-specific biosystem
Canonical NF-kappaB pathway
Death Receptor Signalling, organism-specific biosystem (from REACTOME)
Death Receptor Signalling, organism-specific biosystemThe death receptors, all cell-surface receptors, begin the process of caspase activation. The common feature of these type 1 transmembrane proteins is the "death-domain" a conserved cytoplasmic motif...
Deubiquitination, organism-specific biosystem (from REACTOME)
Deubiquitination, organism-specific biosystemUbiquitination, the modification of proteins by the covalent attachment of ubiquitin (Ub), is a key regulatory mechanism for many many cellular processes, including protein degradation by the 26S pro...
Epstein-Barr virus infection, organism-specific biosystem (from KEGG)
Epstein-Barr virus infection, organism-specific biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
Epstein-Barr virus infection, conserved biosystem (from KEGG)
Epstein-Barr virus infection, conserved biosystemEpstein-Barr virus (EBV) is a ubiquitous human herpesvirus that is associated with oncogenesis. EBV infection to primary human B lymphocytes leads to induction of EBV-specific HLA-restricted cytotoxi...
IL-17 signaling pathway, organism-specific biosystem (from KEGG)
IL-17 signaling pathway, organism-specific biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
IL-17 signaling pathway, conserved biosystem (from KEGG)
IL-17 signaling pathway, conserved biosystemThe interleukin 17 (IL-17) family, a subset of cytokines consisting of IL-17A-F, plays crucial roles in both acute and chronic inflammatory responses. IL-17A, the hallmark cytokine of the newly defi...
Immune System, organism-specific biosystem (from REACTOME)
Immune System, organism-specific biosystemHumans are exposed to millions of potential pathogens daily, through contact, ingestion, and inhalation. Our ability to avoid infection depends on the adaptive immune system and during the first crit...
Innate Immune System, organism-specific biosystem (from REACTOME)
Innate Immune System, organism-specific biosystemInnate immunity encompases the nonspecific part of immunity tha are part of an individual's natural biologic makeup
Measles, organism-specific biosystem (from KEGG)
Measles, organism-specific biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Measles, conserved biosystem (from KEGG)
Measles, conserved biosystemMeasles virus (MV) is highly contagious virus that leads infant death worldwide. Humans are the unique natural reservoir for this virus. It causes severe immunosuppression favouring secondary bacteri...
Metabolism of proteins, organism-specific biosystem (from REACTOME)
Metabolism of proteins, organism-specific biosystemProtein metabolism comprises the pathways of translation, post-translational modification and protein folding.
NF-kappa B signaling pathway, organism-specific biosystem (from KEGG)
NF-kappa B signaling pathway, organism-specific biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
NF-kappa B signaling pathway, conserved biosystem (from KEGG)
NF-kappa B signaling pathway, conserved biosystemNuclear factor-kappa B (NF-kappa B) is the generic name of a family of transcription factors that function as dimers and regulate genes involved in immunity, inflammation and cell survival. There are...
NOD-like receptor signaling pathway, organism-specific biosystem (from KEGG)
NOD-like receptor signaling pathway, organism-specific biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD-like receptor signaling pathway, conserved biosystem (from KEGG)
NOD-like receptor signaling pathway, conserved biosystemSpecific families of pattern recognition receptors are responsible for detecting various pathogens and generating innate immune responses. The intracellular NOD-like receptor (NLR) family contains mo...
NOD1/2 Signaling Pathway, organism-specific biosystem (from REACTOME)
NOD1/2 Signaling Pathway, organism-specific biosystemNOD1 is ubiquitously expressed, while NOD2 expression is restricted to monocytes, macrophages, dendritic cells, and intestinal Paneth cells (Inohara et al. 2005). NOD1 and NOD2 activation induces tra...
Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystem (from REACTOME)
Negative regulators of RIG-I/MDA5 signaling, organism-specific biosystemAs with other cytokine systems, production of type I IFN is a transient process, and can be hazardous to the host if unregulated, resulting in chronic cellular toxicity or inflammatory and autoimmune...
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystem (from REACTOME)
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways, organism-specific biosystemThe innate immune system is the first line of defense against invading microorganisms, a broad specificity response characterized by the recruitment and activation of phagocytes and the release of an...
Ovarian tumor domain proteases, organism-specific biosystem (from REACTOME)
Ovarian tumor domain proteases, organism-specific biosystemHumans have 16 Overian tumour domain (OTU) family DUBs that can be evolutionally divided into three classes, the OTUs, the Otubains (OTUBs), and the A20-like OTUs (Komander et al. 2009). OTU family ...
Post-translational protein modification, organism-specific biosystem (from REACTOME)
Post-translational protein modification, organism-specific biosystemAfter translation, many newly formed proteins undergo further covalent modifications that alter their functional properties and that are essentially irreversible under physiological conditions in the...
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystem (from REACTOME)
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways, organism-specific biosystemRIG-I-like helicases (RLHs) the retinoic acid inducible gene-I (RIG-I) and melanoma differentiation associated gene 5 (MDA5) are RNA helicases that recognize viral RNA present within the cytoplasm. F...
Regulation of TNFR1 signaling, organism-specific biosystem (from REACTOME)
Regulation of TNFR1 signaling, organism-specific biosystemTumor necrosis factor-alpha (TNFalpha) is an inflammatory cytokine, that activates either cell survival (e.g.,inflammation, proliferation) or cell death upon association with TNF receptor 1 (TNFR1). ...
Regulation of toll-like receptor signaling pathway, organism-specific biosystem (from WikiPathways)
Regulation of toll-like receptor signaling pathway, organism-specific biosystem
Regulation of toll-like receptor signaling pathway
Signal Transduction, organism-specific biosystem (from REACTOME)
Signal Transduction, organism-specific biosystemSignal transduction is a process in which extracellular signals elicit changes in cell state and activity. Transmembrane receptors sense changes in the cellular environment by binding ligands, such a...
TNF alpha Signaling Pathway, organism-specific biosystem (from WikiPathways)
TNF alpha Signaling Pathway, organism-specific biosystemTumor necrosis factor alpha (TNF?) is a proinflammatory cytokine involved in various biological processes including regulation of cell proliferation, differentiation, apoptosis and immune response. T...
TNF receptor signaling pathway, organism-specific biosystem (from Pathway Interaction Database)
TNF receptor signaling pathway, organism-specific biosystem
TNF receptor signaling pathway
TNF signaling, organism-specific biosystem (from REACTOME)
TNF signaling, organism-specific biosystemThe inflammatory cytokine tumor necrosis factor alpha (TNF-alpha) is expressed in immune and nonimmune cell types including macrophages, T cells, mast cells, granulocytes, natural killer (NK) cells, ...
TNF signaling pathway, organism-specific biosystem (from KEGG)
TNF signaling pathway, organism-specific biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
TNF signaling pathway, conserved biosystem (from KEGG)
TNF signaling pathway, conserved biosystemTumor necrosis factor (TNF), as a critical cytokine, can induce a wide range of intracellular signal pathways including apoptosis and cell survival as well as inflammation and immunity. Activated TNF...
TNFR1-induced NFkappaB signaling pathway, organism-specific biosystem (from REACTOME)
TNFR1-induced NFkappaB signaling pathway, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce inflammation, cell proliferation, survival or cell death (Ward C et al. 1999; Michea...
TNFR1-induced proapoptotic signaling, organism-specific biosystem (from REACTOME)
TNFR1-induced proapoptotic signaling, organism-specific biosystemActivation of tumor necrosis factor receptor 1 (TNFR1) can trigger multiple signal transduction pathways to induce cell survival or cell death (Ward C et al. 1999; Micheau O and Tschopp J 2003; Wider...

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-M59465 (e-PCR)
- UniSTS:50983

TNFAIP3_431 (e-PCR)
- UniSTS:277825

D6S2077 (e-PCR)
- UniSTS:56662

PMC152246P3 (e-PCR)
- UniSTS:271205

PMC355833P1 (e-PCR)
- UniSTS:273253

PMC355833P2 (e-PCR)
- UniSTS:273254

PMC355833P3 (e-PCR)
- UniSTS:273255

D6S1833 (e-PCR)
- UniSTS:51875

PMC135646P1 (e-PCR)
- UniSTS:270765

PMC135646P2 (e-PCR)
- UniSTS:270766

D6S1858 (e-PCR)
- UniSTS:42178

SHGC-132182 (e-PCR)
- UniSTS:170697

G10608 (e-PCR)
- UniSTS:79322

STS-R70479 (e-PCR)
- UniSTS:6382

Homology

Homologs of the TNFAIP3 gene: The TNFAIP3 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, and zebrafish.
Orthologs from Annotation Pipeline: 276 organisms have orthologs with human gene TNFAIP3
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
DNA binding	IEA Inferred from Electronic Annotation more info
K63-linked polyubiquitin modification-dependent protein binding	IBA Inferred from Biological aspect of Ancestor more info	PubMed
Lys63-specific deubiquitinase activity	EXP Inferred from Experiment more info	PubMed
Lys63-specific deubiquitinase activity	TAS Traceable Author Statement more info
identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
kinase binding	IEA Inferred from Electronic Annotation more info
protease binding	IPI Inferred from Physical Interaction more info	PubMed
protein binding	IPI Inferred from Physical Interaction more info	PubMed
protein self-association	IDA Inferred from Direct Assay more info	PubMed
thiol-dependent ubiquitin-specific protease activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
thiol-dependent ubiquitin-specific protease activity	IDA Inferred from Direct Assay more info	PubMed
thiol-dependent ubiquitin-specific protease activity	TAS Traceable Author Statement more info	PubMed
thiol-dependent ubiquitinyl hydrolase activity	IMP Inferred from Mutant Phenotype more info	PubMed
ubiquitin binding	IPI Inferred from Physical Interaction more info	PubMed
ubiquitin-protein transferase activity	IDA Inferred from Direct Assay more info	PubMed
zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
B-1 B cell homeostasis	ISS Inferred from Sequence or Structural Similarity more info
apoptotic process	IEA Inferred from Electronic Annotation more info
cell migration	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cellular response to hydrogen peroxide	ISS Inferred from Sequence or Structural Similarity more info
cellular response to lipopolysaccharide	IDA Inferred from Direct Assay more info	PubMed
cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info	PubMed
establishment of protein localization to vacuole	IEA Inferred from Electronic Annotation more info
inflammatory response	IEA Inferred from Electronic Annotation more info
negative regulation of B cell activation	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of CD40 signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of I-kappaB kinase/NF-kappaB signaling	IDA Inferred from Direct Assay more info	PubMed
negative regulation of NF-kappaB transcription factor activity	IDA Inferred from Direct Assay more info	PubMed
negative regulation of bone resorption	NAS Non-traceable Author Statement more info	PubMed
negative regulation of chronic inflammatory response	IEA Inferred from Electronic Annotation more info
negative regulation of cyclin-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
negative regulation of endothelial cell apoptotic process	IDA Inferred from Direct Assay more info	PubMed
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors	IDA Inferred from Direct Assay more info	PubMed
negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of innate immune response	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of interleukin-1 beta secretion	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-2 production	IMP Inferred from Mutant Phenotype more info	PubMed
negative regulation of interleukin-6 production	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of osteoclast proliferation	NAS Non-traceable Author Statement more info	PubMed
negative regulation of protein ubiquitination	IDA Inferred from Direct Assay more info	PubMed
negative regulation of smooth muscle cell proliferation	IDA Inferred from Direct Assay more info	PubMed
negative regulation of toll-like receptor 2 signaling pathway	NAS Non-traceable Author Statement more info	PubMed
negative regulation of toll-like receptor 3 signaling pathway	IDA Inferred from Direct Assay more info	PubMed
negative regulation of toll-like receptor 4 signaling pathway	NAS Non-traceable Author Statement more info	PubMed
negative regulation of toll-like receptor 5 signaling pathway	IEA Inferred from Electronic Annotation more info
negative regulation of tumor necrosis factor production	ISS Inferred from Sequence or Structural Similarity more info
negative regulation of type I interferon production	TAS Traceable Author Statement more info
nucleotide-binding oligomerization domain containing signaling pathway	TAS Traceable Author Statement more info
positive regulation of Wnt signaling pathway	IBA Inferred from Biological aspect of Ancestor more info	PubMed
positive regulation of cellular protein catabolic process	IEA Inferred from Electronic Annotation more info
positive regulation of hepatocyte proliferation	IEA Inferred from Electronic Annotation more info
positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
protein K11-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein K29-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein K33-linked deubiquitination	IBA Inferred from Biological aspect of Ancestor more info	PubMed
protein K48-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein K48-linked ubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein K63-linked deubiquitination	IDA Inferred from Direct Assay more info	PubMed
protein complex oligomerization	NAS Non-traceable Author Statement more info	PubMed
protein deubiquitination	TAS Traceable Author Statement more info	PubMed
protein deubiquitination involved in ubiquitin-dependent protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info	PubMed
regulation of defense response to virus by host	NAS Non-traceable Author Statement more info	PubMed
regulation of germinal center formation	ISS Inferred from Sequence or Structural Similarity more info
regulation of tumor necrosis factor-mediated signaling pathway	TAS Traceable Author Statement more info
regulation of vascular wound healing	NAS Non-traceable Author Statement more info	PubMed
response to molecule of bacterial origin	IDA Inferred from Direct Assay more info	PubMed
response to muramyl dipeptide	IEA Inferred from Electronic Annotation more info
tolerance induction to lipopolysaccharide	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
cytoplasm	IBA Inferred from Biological aspect of Ancestor more info	PubMed
cytosol	TAS Traceable Author Statement more info
extracellular exosome	HDA more info	PubMed
intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
lysosome	IEA Inferred from Electronic Annotation more info
nucleus	IBA Inferred from Biological aspect of Ancestor more info	PubMed
nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: tumor necrosis factor alpha-induced protein 3

Names: OTU domain-containing protein 7C; putative DNA-binding protein A20; tumor necrosis factor inducible protein A20; tumor necrosis factor, alpha induced protein 3; zinc finger protein A20

NP_001257436.1

EC 3.4.19.12

NP_001257437.1

EC 3.4.19.12

NP_006281.1

EC 3.4.19.12

XP_005267176.1

EC 3.4.19.12

XP_006715618.1

EC 3.4.19.12

XP_011534397.1

EC 3.4.19.12

XP_011534398.1

EC 3.4.19.12

XP_024302300.1

EC 3.4.19.12

XP_024302301.1

EC 3.4.19.12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_032761.1 RefSeqGene

Range

4745..20871

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001270507.2 → NP_001257436.1 tumor necrosis factor alpha-induced protein 3

See identical proteins and their annotated locations for NP_001257436.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

CB528739, DB143089, M59465

Consensus CDS

CCDS5187.1

UniProtKB/Swiss-Prot

P21580

Conserved Domains (2) summary

smart00259
Location:759 → 784

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
NM_001270508.2 → NP_001257437.1 tumor necrosis factor alpha-induced protein 3

See identical proteins and their annotated locations for NP_001257437.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript. All three variants encode the same protein.

Source sequence(s)

CB528739, HY009939, M59465

Consensus CDS

CCDS5187.1

UniProtKB/Swiss-Prot

P21580

Related

ENSP00000481570.1, ENST00000612899.5

Conserved Domains (2) summary

smart00259
Location:759 → 784

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
NM_006290.4 → NP_006281.1 tumor necrosis factor alpha-induced protein 3

See identical proteins and their annotated locations for NP_006281.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.

Source sequence(s)

CB528739, HY085289, M59465

Consensus CDS

CCDS5187.1

UniProtKB/Swiss-Prot

P21580

Related

ENSP00000237289.4, ENST00000237289.8

Conserved Domains (2) summary

smart00259
Location:759 → 784

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000006.12 Reference GRCh38.p13 Primary Assembly

Range

137866317..137883312

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011536095.1 → XP_011534397.1 tumor necrosis factor alpha-induced protein 3 isoform X1

See identical proteins and their annotated locations for XP_011534397.1

UniProtKB/Swiss-Prot

P21580

Conserved Domains (2) summary

smart00259
Location:759 → 784

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
XM_011536096.2 → XP_011534398.1 tumor necrosis factor alpha-induced protein 3 isoform X2

Conserved Domains (2) summary

smart00259
Location:475 → 500

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
XM_024446532.1 → XP_024302300.1 tumor necrosis factor alpha-induced protein 3 isoform X1

Conserved Domains (2) summary

smart00259
Location:759 → 784

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
XM_024446533.1 → XP_024302301.1 tumor necrosis factor alpha-induced protein 3 isoform X1

Conserved Domains (2) summary

smart00259
Location:759 → 784

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
XM_005267119.1 → XP_005267176.1 tumor necrosis factor alpha-induced protein 3 isoform X1

See identical proteins and their annotated locations for XP_005267176.1

UniProtKB/Swiss-Prot

P21580

Related

ENSP00000481454.1, ENST00000620204.3

Conserved Domains (2) summary

smart00259
Location:759 → 784

ZnF_A20; A20-like zinc fingers

pfam02338
Location:98 → 257

OTU; OTU-like cysteine protease
XM_006715555.1 → XP_006715618.1 tumor necrosis factor alpha-induced protein 3 isoform X3

Conserved Domains (2) summary

smart00259
Location:546 → 571

ZnF_A20; A20-like zinc fingers

cl19932
Location:6 → 44

OTU; OTU-like cysteine protease