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Tnfaip3 tumor necrosis factor, alpha-induced protein 3 [ Mus musculus (house mouse) ]

Gene ID: 21929, updated on 8-Feb-2024

Summary

Official Symbol
Tnfaip3provided by MGI
Official Full Name
tumor necrosis factor, alpha-induced protein 3provided by MGI
Primary source
MGI:MGI:1196377
See related
Ensembl:ENSMUSG00000019850 AllianceGenome:MGI:1196377
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
A20; Tnfip3
Summary
Enables kinase binding activity and protein C-terminus binding activity. Involved in several processes, including negative regulation of cytokine production; negative regulation of defense response; and negative regulation of signal transduction. Acts upstream of or within establishment of protein localization to vacuole; positive regulation of cellular protein catabolic process; and protein K63-linked deubiquitination. Located in cytoplasm. Is expressed in central nervous system; genitourinary system; heart; and retina nuclear layer. Human ortholog(s) of this gene implicated in familial Behcet-like autoinflammatory syndrome. Orthologous to human TNFAIP3 (TNF alpha induced protein 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in thymus adult (RPKM 11.6), spleen adult (RPKM 5.3) and 20 other tissues See more
Orthologs
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Genomic context

See Tnfaip3 in Genome Data Viewer
Location:
10 A3; 10 8.08 cM
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (18876658..18891158, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (19000910..19015410, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 32926 Neighboring gene RIKEN cDNA 4930444F02 gene Neighboring gene STARR-seq mESC enhancer starr_25919 Neighboring gene PERP, TP53 apoptosis effector Neighboring gene STARR-positive B cell enhancer mm9_chr10:18636945-18637246 Neighboring gene STARR-positive B cell enhancer ABC_E2316 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18735436-18735619 Neighboring gene STARR-positive B cell enhancer mm9_chr10:18763751-18764052 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18782097-18782280 Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:18782393-18782602 Neighboring gene RIKEN cDNA 1700124M09 gene Neighboring gene predicted gene, 51814

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables K63-linked deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables K63-linked polyubiquitin modification-dependent protein binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
 
enables cysteine-type deubiquitinase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables cysteine-type deubiquitinase activity ISO
Inferred from Sequence Orthology
more info
 
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
 
enables kinase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables protease binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein self-association ISO
Inferred from Sequence Orthology
more info
 
enables transferase activity IEA
Inferred from Electronic Annotation
more info
 
enables ubiquitin binding ISO
Inferred from Sequence Orthology
more info
 
enables ubiquitin-protein transferase activity ISO
Inferred from Sequence Orthology
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in B-1 B cell homeostasis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within apoptotic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in cellular response to hydrogen peroxide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in cellular response to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
involved_in cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within establishment of protein localization to vacuole IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within inflammatory response IEA
Inferred from Electronic Annotation
more info
 
involved_in marginal zone B cell differentiation NAS
Non-traceable Author Statement
more info
PubMed 
acts_upstream_of_or_within metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of B cell activation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of CD40 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of NF-kappaB transcription factor activity ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of autophagy NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of canonical NF-kappaB signal transduction ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of chronic inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of cyclin-dependent protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of endothelial cell apoptotic process ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of extrinsic apoptotic signaling pathway via death domain receptors NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of granuloma formation NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of heterotypic cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of inflammatory response IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of inflammatory response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of innate immune response IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of interleukin-1 beta production IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within negative regulation of interleukin-1 beta production ISO
Inferred from Sequence Orthology
more info
PubMed 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-6 production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of protein ubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of smooth muscle cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of toll-like receptor 3 signaling pathway ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of toll-like receptor 5 signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
involved_in negative regulation of tumor necrosis factor production IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of Wnt signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in positive regulation of hepatocyte proliferation IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within positive regulation of protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of protein catabolic process ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K11-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K29-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K33-linked deubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in protein K48-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein K48-linked ubiquitination ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within protein K63-linked deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein K63-linked deubiquitination ISO
Inferred from Sequence Orthology
more info
 
involved_in protein deubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
involved_in protein deubiquitination involved in ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of germinal center formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of immunoglobulin production IC
Inferred by Curator
more info
PubMed 
involved_in regulation of innate immune response IC
Inferred by Curator
more info
PubMed 
involved_in response to molecule of bacterial origin IDA
Inferred from Direct Assay
more info
PubMed 
involved_in response to molecule of bacterial origin ISO
Inferred from Sequence Orthology
more info
 
involved_in response to muramyl dipeptide IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in response to wounding NAS
Non-traceable Author Statement
more info
PubMed 
involved_in tolerance induction to lipopolysaccharide ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in lysosome IEA
Inferred from Electronic Annotation
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in nucleus ISO
Inferred from Sequence Orthology
more info
 

General protein information

Preferred Names
tumor necrosis factor alpha-induced protein 3
Names
TNF alpha-induced protein 3
putative DNA-binding protein A20
tumor necrosis factor induced protein 3
zinc finger protein A20
NP_001159874.1
NP_033423.3
XP_006512765.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001166402.1NP_001159874.1  tumor necrosis factor alpha-induced protein 3 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains a distinct 5' UTR and 5' coding region, compared to variant 1. The resulting protein (isoform 2) has a longer N-terminus, compared to isoform 1.
    Source sequence(s)
    AC102657, AK171326, BC054806
    UniProtKB/TrEMBL
    Q3U695, Q7TQD1
    Related
    ENSMUSP00000101167.2, ENSMUST00000105527.2
    Conserved Domains (2) summary
    smart00259
    Location:781806
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:135294
    OTU; OTU-like cysteine protease
  2. NM_009397.3NP_033423.3  tumor necrosis factor alpha-induced protein 3 isoform 1

    See identical proteins and their annotated locations for NP_033423.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the shorter isoform (1).
    Source sequence(s)
    AK151921, BC054806
    Consensus CDS
    CCDS23715.1
    UniProtKB/Swiss-Prot
    Q3U968, Q60769
    UniProtKB/TrEMBL
    Q3U695, Q7TQD1
    Related
    ENSMUSP00000019997.5, ENSMUST00000019997.11
    Conserved Domains (3) summary
    smart00259
    Location:744769
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
    pfam15548
    Location:528622
    DUF4655; Domain of unknown function (DUF4655)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    18876658..18891158 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006512702.4XP_006512765.1  tumor necrosis factor alpha-induced protein 3 isoform X1

    See identical proteins and their annotated locations for XP_006512765.1

    UniProtKB/Swiss-Prot
    Q3U968, Q60769
    UniProtKB/TrEMBL
    Q3U695, Q7TQD1
    Conserved Domains (3) summary
    smart00259
    Location:744769
    ZnF_A20; A20-like zinc fingers
    pfam02338
    Location:98257
    OTU; OTU-like cysteine protease
    pfam15548
    Location:528622
    DUF4655; Domain of unknown function (DUF4655)