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Dlg5 discs large MAGUK scaffold protein 5 [ Mus musculus (house mouse) ]

Gene ID: 71228, updated on 8-Feb-2024

Summary

Official Symbol
Dlg5provided by MGI
Official Full Name
discs large MAGUK scaffold protein 5provided by MGI
Primary source
MGI:MGI:1918478
See related
Ensembl:ENSMUSG00000021782 AllianceGenome:MGI:1918478
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
mKIAA0583; 4933429D20Rik
Summary
Predicted to enable beta-catenin binding activity and cytoskeletal protein binding activity. Involved in positive regulation of dendritic spine development; positive regulation of synapse assembly; and regulation of signal transduction. Acts upstream of or within several processes, including animal organ development; apical protein localization; and protein localization to adherens junction. Located in adherens junction; ciliary basal body; and postsynaptic density. Is expressed in several structures, including alimentary system; hemolymphoid system gland; lung; nervous system; and reproductive system. Orthologous to human DLG5 (discs large MAGUK scaffold protein 5). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in limb E14.5 (RPKM 14.4), genital fat pad adult (RPKM 13.1) and 24 other tissues See more
Orthologs
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Genomic context

See Dlg5 in Genome Data Viewer
Location:
14 A3; 14 14.26 cM
Exon count:
34
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 14 NC_000080.7 (24184021..24295988, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 14 NC_000080.6 (24133953..24245920, complement)

Chromosome 14 - NC_000080.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_36177 Neighboring gene microRNA 7210 Neighboring gene predicted gene, 52142 Neighboring gene predicted gene, 52143 Neighboring gene STARR-seq mESC enhancer starr_36186 Neighboring gene VISTA enhancer mm1485 Neighboring gene STARR-seq mESC enhancer starr_36187 Neighboring gene RIKEN cDNA E330034G19 gene Neighboring gene polymerase (RNA) III (DNA directed) polypeptide A pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables beta-catenin binding ISO
Inferred from Sequence Orthology
more info
 
enables cytoskeletal protein binding ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within apical protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in epithelial to mesenchymal transition ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within epithelial tube branching involved in lung morphogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within establishment or maintenance of epithelial cell apical/basal polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in maintenance of cell polarity ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within metanephric collecting duct development IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within midbrain development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of T cell proliferation ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
acts_upstream_of_or_within neuroepithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within polarized epithelial cell differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of dendritic spine development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of hippo signaling ISO
Inferred from Sequence Orthology
more info
 
involved_in positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of synapse assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in postsynapse organization IDA
Inferred from Direct Assay
more info
PubMed 
involved_in postsynapse organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein localization to adherens junction IMP
Inferred from Mutant Phenotype
more info
PubMed 
acts_upstream_of_or_within protein-containing complex assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
acts_upstream_of_or_within zonula adherens assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in adherens junction IDA
Inferred from Direct Assay
more info
PubMed 
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell junction ISO
Inferred from Sequence Orthology
more info
 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in ciliary basal body IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in glutamatergic synapse IEP
Inferred from Expression Pattern
more info
PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic density IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic density IEP
Inferred from Expression Pattern
more info
PubMed 
located_in synapse IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
disks large homolog 5
Names
discs, large homolog 5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001163513.1NP_001156985.1  disks large homolog 5 isoform 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK147598, AK147699, BC067046
    Consensus CDS
    CCDS49417.1
    UniProtKB/Swiss-Prot
    E9Q9R9, Q3UGX5
    UniProtKB/TrEMBL
    Q3UH41
    Related
    ENSMUSP00000087879.5, ENSMUST00000090398.11
    Conserved Domains (8) summary
    cd11860
    Location:16001662
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17341910
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13471429
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:722790
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:129213
    Takusan; Takusan
    pfam14197
    Location:545585
    Cep57_CLD_2; Centrosome localization domain of PPC89
    pfam16610
    Location:14271502
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl25732
    Location:141564
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_027726.1NP_082002.1  disks large homolog 5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1.
    Source sequence(s)
    AK147598, AK147699, BC067046
    Consensus CDS
    CCDS49416.1
    UniProtKB/TrEMBL
    E9Q9I2, Q3UH41
    Related
    ENSMUSP00000073367.7, ENSMUST00000073687.13
    Conserved Domains (10) summary
    cd11860
    Location:15771639
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17111887
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13241406
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1340
    Location:272564
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:699767
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:17171886
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:107189
    Takusan; Takusan
    pfam16610
    Location:14041479
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:394578
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:287426
    FliJ; Flagellar FliJ protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000080.7 Reference GRCm39 C57BL/6J

    Range
    24184021..24295988 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006519560.3XP_006519623.1  disks large homolog 5 isoform X3

    UniProtKB/TrEMBL
    Q3UH41
    Conserved Domains (8) summary
    cd11860
    Location:16051667
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17391915
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13521434
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:141564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:736795
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:129213
    Takusan
    pfam14197
    Location:545585
    Cep57_CLD_2; Centrosome localization domain of PPC89
    pfam16610
    Location:14321507
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
  2. XM_017316199.2XP_017171688.1  disks large homolog 5 isoform X4

    UniProtKB/TrEMBL
    Q3UH41
    Conserved Domains (7) summary
    cd11860
    Location:16051667
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17391915
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13521434
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:141564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:727795
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:129213
    Takusan
    pfam16610
    Location:14321507
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
  3. XM_017316198.2XP_017171687.1  disks large homolog 5 isoform X2

    UniProtKB/TrEMBL
    Q3UH41
    Conserved Domains (7) summary
    cd11860
    Location:16091671
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17431919
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13571439
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:141564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:741800
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:129213
    Takusan
    pfam16610
    Location:14371511
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
  4. XM_017316197.2XP_017171686.1  disks large homolog 5 isoform X1

    UniProtKB/TrEMBL
    Q3UH41
    Conserved Domains (7) summary
    cd11860
    Location:16101672
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17441920
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13571439
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:141564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:741800
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:129213
    Takusan
    pfam16610
    Location:14371512
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
  5. XM_017316200.3XP_017171689.1  disks large homolog 5 isoform X5

    UniProtKB/TrEMBL
    Q3UH41
    Conserved Domains (7) summary
    cd11860
    Location:15871649
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17211897
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13341416
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:118541
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:718777
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:106190
    Takusan
    pfam16610
    Location:14141489
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
  6. XM_017316201.3XP_017171690.1  disks large homolog 5 isoform X6

    UniProtKB/TrEMBL
    Q3UH41
    Related
    ENSMUSP00000044852.7, ENSMUST00000042009.13
    Conserved Domains (6) summary
    cd11860
    Location:15621624
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:16961872
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13091391
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:150516
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:693752
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16610
    Location:13891464
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
  7. XM_017316202.1XP_017171691.1  disks large homolog 5 isoform X7

    UniProtKB/TrEMBL
    Q3UH41
    Conserved Domains (7) summary
    cd11860
    Location:15251587
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:16591835
    GuKc; Guanylate kinase homologues
    smart00228
    Location:12721354
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:56479
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:656715
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:44128
    Takusan
    pfam16610
    Location:13521427
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
  8. XM_017316203.2XP_017171692.1  disks large homolog 5 isoform X8

    UniProtKB/TrEMBL
    Q3UH41
    Conserved Domains (6) summary
    cd11860
    Location:16101672
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00228
    Location:13571439
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG1196
    Location:141564
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    cd00992
    Location:741800
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:129213
    Takusan
    pfam16610
    Location:14371512
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5