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DLG5 discs large MAGUK scaffold protein 5 [ Homo sapiens (human) ]

Gene ID: 9231, updated on 6-Jan-2019

Summary

Official Symbol
DLG5provided by HGNC
Official Full Name
discs large MAGUK scaffold protein 5provided by HGNC
Primary source
HGNC:HGNC:2904
See related
Ensembl:ENSG00000151208 MIM:604090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PDLG; LP-DLG; P-DLG5
Summary
This gene encodes a member of the family of discs large (DLG) homologs, a subset of the membrane-associated guanylate kinase (MAGUK) superfamily. The MAGUK proteins are composed of a catalytically inactive guanylate kinase domain, in addition to PDZ and SH3 domains, and are thought to function as scaffolding molecules at sites of cell-cell contact. The protein encoded by this gene localizes to the plasma membrane and cytoplasm, and interacts with components of adherens junctions and the cytoskeleton. It is proposed to function in the transmission of extracellular signals to the cytoskeleton and in the maintenance of epithelial cell structure. Alternative splice variants have been described but their biological nature has not been determined. [provided by RefSeq, Jul 2008]
Expression
Broad expression in placenta (RPKM 23.0), skin (RPKM 17.3) and 22 other tissues See more
Orthologs

Genomic context

See DLG5 in Genome Data Viewer
Location:
10q22.3
Exon count:
43
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 10 NC_000010.11 (77790787..77926590, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (79550549..79686348, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 1266, pseudogene Neighboring gene inosine monophosphate dehydrogenase 1 pseudogene 5 Neighboring gene uncharacterized LOC101929347 Neighboring gene NFE2L2 motif-containing MPRA enhancers 69 and 123 Neighboring gene RNA, 7SL, cytoplasmic 284, pseudogene Neighboring gene DLG5 antisense RNA 1 Neighboring gene H2A histone family member Z pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.
NHGRI GWA Catalog
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0583

Gene Ontology Provided by GOA

Function Evidence Code Pubs
beta-catenin binding IDA
Inferred from Direct Assay
more info
PubMed 
cytoskeletal protein binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
receptor signaling complex scaffold activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
apical protein localization IEA
Inferred from Electronic Annotation
more info
 
cell-cell adhesion NAS
Non-traceable Author Statement
more info
PubMed 
epithelial to mesenchymal transition IMP
Inferred from Mutant Phenotype
more info
PubMed 
epithelial tube branching involved in lung morphogenesis IEA
Inferred from Electronic Annotation
more info
 
establishment or maintenance of epithelial cell apical/basal polarity IEA
Inferred from Electronic Annotation
more info
 
intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
maintenance of cell polarity IMP
Inferred from Mutant Phenotype
more info
PubMed 
metanephric collecting duct development IEA
Inferred from Electronic Annotation
more info
 
midbrain development IEA
Inferred from Electronic Annotation
more info
 
negative regulation of T cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of cell proliferation TAS
Traceable Author Statement
more info
PubMed 
negative regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
polarized epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
positive regulation of dendritic spine development ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of hippo signaling IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of synapse assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein localization to adherens junction IEA
Inferred from Electronic Annotation
more info
 
protein-containing complex assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
zonula adherens assembly IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
PubMed 
cell-cell adherens junction IEA
Inferred from Electronic Annotation
more info
 
ciliary basal body ISS
Inferred from Sequence or Structural Similarity
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane TAS
Traceable Author Statement
more info
PubMed 
postsynaptic density ISS
Inferred from Sequence or Structural Similarity
more info
 
postsynaptic membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
disks large homolog 5
Names
discs large protein LP-DLG
discs large protein P-dlg
discs, large homolog 5
large type of P-DLG
placenta and prostate DLG

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_011484.1 RefSeqGene

    Range
    5001..140800
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_004747.4NP_004738.3  disks large homolog 5

    See identical proteins and their annotated locations for NP_004738.3

    Status: REVIEWED

    Source sequence(s)
    AB011155, AK122931, AL391421, BC030250
    Consensus CDS
    CCDS7353.2
    UniProtKB/Swiss-Prot
    Q8TDM6
    Related
    ENSP00000361467.2, ENST00000372391.6
    Conserved Domains (12) summary
    cd11860
    Location:15971659
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17321908
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13471429
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:702771
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:295587
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:722790
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:17401907
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:130212
    Takusan; Takusan
    pfam07926
    Location:231353
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam16610
    Location:14271499
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:417601
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:310449
    FliJ; Flagellar FliJ protein

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p12 Primary Assembly

    Range
    77790787..77926590 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270276.4XP_005270333.1  disks large homolog 5 isoform X1

    See identical proteins and their annotated locations for XP_005270333.1

    Conserved Domains (12) summary
    cd11860
    Location:15931655
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:17281904
    GuKc; Guanylate kinase homologues
    smart00228
    Location:13431425
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:698767
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:291583
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:718786
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:17361903
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:130208
    Takusan; Takusan
    pfam08614
    Location:151345
    ATG16; Autophagy protein 16 (ATG16)
    pfam16610
    Location:14231495
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:413597
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:306445
    FliJ; Flagellar FliJ protein
  2. XM_006718056.3XP_006718119.1  disks large homolog 5 isoform X10

    See identical proteins and their annotated locations for XP_006718119.1

    UniProtKB/Swiss-Prot
    Q8TDM6
    Conserved Domains (11) summary
    cd11860
    Location:12571319
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:13921568
    GuKc; Guanylate kinase homologues
    smart00228
    Location:10071089
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:702771
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:295587
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:722790
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:14001567
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:130212
    Takusan; Takusan
    pfam16610
    Location:10871159
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:417601
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:310449
    FliJ; Flagellar FliJ protein
  3. XM_011540342.1XP_011538644.1  disks large homolog 5 isoform X3

    See identical proteins and their annotated locations for XP_011538644.1

    Conserved Domains (13) summary
    cd11860
    Location:15071569
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:16421818
    GuKc; Guanylate kinase homologues
    smart00228
    Location:12571339
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:612681
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:205497
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:632700
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:16501817
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:40122
    Takusan; Takusan
    pfam07926
    Location:141263
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam16610
    Location:13371409
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:327511
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23720
    Location:138236
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23733
    Location:220359
    FliJ; Flagellar FliJ protein
  4. XM_017016914.1XP_016872403.1  disks large homolog 5 isoform X5

    UniProtKB/Swiss-Prot
    Q8TDM6
    Conserved Domains (12) summary
    cd11860
    Location:14871549
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:16221798
    GuKc; Guanylate kinase homologues
    smart00228
    Location:12371319
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:592661
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:185477
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:612680
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:16301797
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:20102
    Takusan; Takusan
    pfam07926
    Location:121243
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam16610
    Location:13171389
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:307491
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:200339
    FliJ; Flagellar FliJ protein
  5. XM_011540341.3XP_011538643.1  disks large homolog 5 isoform X2

    See identical proteins and their annotated locations for XP_011538643.1

    Conserved Domains (13) summary
    cd11860
    Location:15381600
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:16731849
    GuKc; Guanylate kinase homologues
    smart00228
    Location:12881370
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:643712
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:236528
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:663731
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:16811848
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:71153
    Takusan; Takusan
    pfam07926
    Location:172294
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam16610
    Location:13681440
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:358542
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23720
    Location:169267
    RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    cl23733
    Location:251390
    FliJ; Flagellar FliJ protein
  6. XM_017016913.1XP_016872402.1  disks large homolog 5 isoform X4

  7. XM_011540345.1XP_011538647.1  disks large homolog 5 isoform X7

    See identical proteins and their annotated locations for XP_011538647.1

    UniProtKB/Swiss-Prot
    Q8TDM6
    Conserved Domains (12) summary
    cd11860
    Location:14421504
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:15771753
    GuKc; Guanylate kinase homologues
    smart00228
    Location:11921274
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:547616
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:140432
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:567635
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:15851752
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:157
    Takusan; Takusan
    pfam07926
    Location:76198
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam16610
    Location:12721344
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:262446
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:155294
    FliJ; Flagellar FliJ protein
  8. XM_011540344.2XP_011538646.1  disks large homolog 5 isoform X6

    See identical proteins and their annotated locations for XP_011538646.1

    Conserved Domains (12) summary
    cd11860
    Location:14851547
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:16201796
    GuKc; Guanylate kinase homologues
    smart00228
    Location:12351317
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:590659
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:183475
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:610678
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:16281795
    Guanylate_kin; Guanylate kinase
    pfam04822
    Location:18100
    Takusan; Takusan
    pfam07926
    Location:119241
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam16610
    Location:13151387
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:305489
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:198337
    FliJ; Flagellar FliJ protein
  9. XM_011540347.2XP_011538649.1  disks large homolog 5 isoform X9

    See identical proteins and their annotated locations for XP_011538649.1

    Conserved Domains (10) summary
    cd11860
    Location:12911353
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:14261602
    GuKc; Guanylate kinase homologues
    smart00228
    Location:10411123
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:396465
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:27281
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:416484
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:14341601
    Guanylate_kin; Guanylate kinase
    pfam16610
    Location:11211193
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:111295
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:4143
    FliJ; Flagellar FliJ protein
  10. XM_017016915.1XP_016872404.1  disks large homolog 5 isoform X9

    Conserved Domains (10) summary
    cd11860
    Location:12911353
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:14261602
    GuKc; Guanylate kinase homologues
    smart00228
    Location:10411123
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:396465
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:27281
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:416484
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam00625
    Location:14341601
    Guanylate_kin; Guanylate kinase
    pfam16610
    Location:11211193
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:111295
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:4143
    FliJ; Flagellar FliJ protein
  11. XM_024448250.1XP_024304018.1  disks large homolog 5 isoform X11

    Conserved Domains (7) summary
    cd11860
    Location:11121174
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00072
    Location:12471423
    GuKc; Guanylate kinase homologues
    smart00228
    Location:862944
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    cd00992
    Location:237305
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam16610
    Location:9421014
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl26464
    Location:490863
    Atrophin-1; Atrophin-1 family
    cl26472
    Location:9149
    DUF3084; Protein of unknown function (DUF3084)
  12. XM_011540346.2XP_011538648.1  disks large homolog 5 isoform X8

    See identical proteins and their annotated locations for XP_011538648.1

    Conserved Domains (10) summary
    cd11860
    Location:15971656
    SH3_DLG5; Src homology 3 domain of Disks Large homolog 5
    smart00228
    Location:13471429
    PDZ; Domain present in PSD-95, Dlg, and ZO-1/2
    COG0265
    Location:702771
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:295587
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:722790
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:130212
    Takusan; Takusan
    pfam07926
    Location:231353
    TPR_MLP1_2; TPR/MLP1/MLP2-like protein
    pfam16610
    Location:14271499
    dbPDZ_assoc; Unstructured region between two PDZ domains on Dlg5
    cl12013
    Location:417601
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:310449
    FliJ; Flagellar FliJ protein
  13. XM_006718057.3XP_006718120.1  disks large homolog 5 isoform X12

    See identical proteins and their annotated locations for XP_006718120.1

    Conserved Domains (6) summary
    COG0265
    Location:702771
    DegQ; Periplasmic serine protease, S1-C subfamily, contain C-terminal PDZ domain [Posttranslational modification, protein turnover, chaperones]
    COG1340
    Location:295587
    COG1340; Uncharacterized coiled-coil protein, contains DUF342 domain [Function unknown]
    cd00992
    Location:722790
    PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
    pfam04822
    Location:130212
    Takusan; Takusan
    cl12013
    Location:417601
    BAR; The Bin/Amphiphysin/Rvs (BAR) domain, a dimerization module that binds membranes and detects membrane curvature
    cl23733
    Location:310449
    FliJ; Flagellar FliJ protein

RNA

  1. XR_945874.2 RNA Sequence

Reference GRCh38.p12 ALT_REF_LOCI_1

Genomic

  1. NT_187580.1 Reference GRCh38.p12 ALT_REF_LOCI_1

    Range
    29483..165282 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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